Ben Ridley
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View article: A multiplex of connectome trajectories enables several connectivity patterns in parallel
A multiplex of connectome trajectories enables several connectivity patterns in parallel Open
Complex brain function comprises a multitude of neural operations in parallel and often at different speeds. Each of these operations is carried out across a network of distributed brain regions. How multiple distributed processes are faci…
View article: A multiplex of connectome trajectories enables several connectivity patterns in parallel
A multiplex of connectome trajectories enables several connectivity patterns in parallel Open
Complex brain function comprises a multitude of neural operations in parallel and often at different speeds. Each of these operations is carried out across a network of distributed brain regions. How multiple distributed processes are faci…
View article: A multiplex of connectome trajectories enables several connectivity patterns in parallel
A multiplex of connectome trajectories enables several connectivity patterns in parallel Open
Complex brain function comprises a multitude of neural operations in parallel and often at different speeds. Each of these operations is carried out across a network of distributed brain regions. How multiple distributed processes are faci…
View article: Recommendations for essential medicines for multiple sclerosis in low-resource settings
Recommendations for essential medicines for multiple sclerosis in low-resource settings Open
Background: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that, when untreated, can lead to significant disability in young adults. Despite the increase in the number of disease-modifying therapies (DMTs)…
View article: Azathioprine for people with multiple sclerosis
Azathioprine for people with multiple sclerosis Open
Azathioprine has been proposed as an alternative treatment for MS when access to approved, on-label DMTs is limited, especially in resource-limited settings. The limited evidence available suggests that azathioprine may result in a modest …
View article: Immunomodulators and immunosuppressants for progressive multiple sclerosis: a network meta-analysis
Immunomodulators and immunosuppressants for progressive multiple sclerosis: a network meta-analysis Open
The number of people with PMS with relapses is probably slightly reduced with rituximab at two years, and interferon beta-1b at three years, compared to placebo. Both drugs are also probably associated with a slightly higher proportion of …
View article: A multiplex of connectome trajectories enables several connectivity patterns in parallel
A multiplex of connectome trajectories enables several connectivity patterns in parallel Open
Complex brain function comprises a multitude of neural operations in parallel and often at different speeds. Each of these operations is carried out across a network of distributed brain regions. How multiple distributed processes are faci…
View article: A multiplex of connectome trajectories enables several connectivity patterns in parallel
A multiplex of connectome trajectories enables several connectivity patterns in parallel Open
Complex brain function comprises a multitude of neural operations in parallel and often at different speeds. Each of these operations is carried out across a network of distributed brain regions. How multiple distributed processes are faci…
View article: Immunomodulators and immunosuppressants for relapsing-remitting multiple sclerosis: a network meta-analysis
Immunomodulators and immunosuppressants for relapsing-remitting multiple sclerosis: a network meta-analysis Open
We are highly confident that, compared to placebo, two-year treatment with natalizumab, cladribine, or alemtuzumab decreases relapses more than with other DMTs. We are moderately confident that a two-year treatment with natalizumab may slo…
View article: Altered correlation of concurrently recorded EEG-fMRI connectomes in temporal lobe epilepsy
Altered correlation of concurrently recorded EEG-fMRI connectomes in temporal lobe epilepsy Open
Whole-brain functional connectivity networks (connectomes) have been characterized at different scales in humans using EEG and fMRI. Multimodal epileptic networks have also been investigated, but the relationship between EEG and fMRI defin…
View article: Variability by region and method in human brain sodium concentrations estimated by<sup>23</sup>Na magnetic resonance imaging: a meta-analysis
Variability by region and method in human brain sodium concentrations estimated by<sup>23</sup>Na magnetic resonance imaging: a meta-analysis Open
Sodium imaging ( 23 Na-MRI) is of interest in neurological conditions given potential sensitivity to the physiological and metabolic status of tissues. Benchmarks have so far been restricted to parenchyma or grey/white matter (GM/WM). We i…
View article: Immunomodulators and immunosuppressants for progressive multiple sclerosis: a network meta-analysis
Immunomodulators and immunosuppressants for progressive multiple sclerosis: a network meta-analysis Open
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. We will perform a network meta-analysis to assess the relative effectiveness and safety of immunomodulatory and immunosuppressive treatmen…
View article: Combining sodium <scp>MRI</scp> , proton <scp>MR</scp> spectroscopic imaging, and intracerebral <scp>EEG</scp> in epilepsy
Combining sodium <span>MRI</span> , proton <span>MR</span> spectroscopic imaging, and intracerebral <span>EEG</span> in epilepsy Open
Whole brain ionic and metabolic imaging has potential as a powerful tool for the characterization of brain diseases. We combined sodium MRI ( 23 Na MRI) and 1 H‐MR Spectroscopic Imaging ( 1 H‐MRSI), assessing changes within epileptogenic n…
View article: Combining Sodium MRI, Proton MR Spectroscopic Imaging and Intracerebral EEG in Epilepsy
Combining Sodium MRI, Proton MR Spectroscopic Imaging and Intracerebral EEG in Epilepsy Open
Whole brain ionic and metabolic imaging has potential as a powerful tool for the characterization of brain diseases. In this study we combined sodium MRI ( 23 Na MRI) and 1 H-MR Spectroscopic Imaging ( 1 H-MRSI) and compared ionic/metaboli…
View article: A multiplex of connectome trajectories enables several connectivity patterns in parallel
A multiplex of connectome trajectories enables several connectivity patterns in parallel Open
Complex brain function comprises a multitude of neural operations in parallel and often at different speeds. Each of these operations is carried out across a network of distributed brain regions. How multiple distributed processes are faci…
View article: Automatic segmentation of deep grey nuclei using a high‐resolution 7T magnetic resonance imaging atlas—Quantification of T1 values in healthy volunteers
Automatic segmentation of deep grey nuclei using a high‐resolution 7T magnetic resonance imaging atlas—Quantification of T1 values in healthy volunteers Open
We present a new consensus atlas of deep grey nuclei obtained by shape‐based averaging of manual segmentation of two experienced neuroradiologists and optimized from 7T MP2RAGE images acquired at (.6 mm) 3 in 60 healthy subjects. A group‐w…
View article: Azathioprine for people with multiple sclerosis
Azathioprine for people with multiple sclerosis Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: The objectives of the review are to estimate the benefits and harms of: azathioprine (AZA) compared with placebo or other disease ‐modifying treatments…
View article: Structural Connectivity Alterations in Amyotrophic Lateral Sclerosis: A Graph Theory Based Imaging Study
Structural Connectivity Alterations in Amyotrophic Lateral Sclerosis: A Graph Theory Based Imaging Study Open
Our study provides evidence that alterations of structural connectivity in ALS are primarily driven by node degree and white matter tract degeneration within an extended network around the precentral and the paracentral areas without hub-c…
View article: Connectivity strength, time lag structure and the epilepsy network in resting-state fMRI
Connectivity strength, time lag structure and the epilepsy network in resting-state fMRI Open
The relationship between the epilepsy network, intrinsic brain networks and hypersynchrony in epilepsy remains incompletely understood. To converge upon a synthesized understanding of these features, we studied two elements of functional c…
View article: Metabolic counterparts of sodium accumulation in multiple sclerosis: A whole brain <sup>23</sup>Na-MRI and fast <sup>1</sup>H-MRSI study
Metabolic counterparts of sodium accumulation in multiple sclerosis: A whole brain <sup>23</sup>Na-MRI and fast <sup>1</sup>H-MRSI study Open
Background: Increase of brain total sodium concentrations (TSC) is present in multiple sclerosis (MS), but its pathological involvement has not been assessed yet. Objective: To determine in vivo the metabolic counterpart of brain sodium ac…