Jennifer Ben Salem
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View article: Anandamide Modulates Thermal Avoidance in Caenorhabditis elegans through Vanilloid and Cannabinoid Receptor Interplay
Anandamide Modulates Thermal Avoidance in Caenorhabditis elegans through Vanilloid and Cannabinoid Receptor Interplay Open
Understanding the endocannabinoid system in C. elegans may offer insights into basic biological processes and potential therapeutic targets for managing pain and inflammation in human. It is well established that anandamide modulates pain …
View article: Deletion of Tac1 gene impact kinase phosphorylation involved in signaling pathways associated with pain
Deletion of Tac1 gene impact kinase phosphorylation involved in signaling pathways associated with pain Open
Pain in elderly persons is often not adequately treated, and current treatments may lead to poor outcomes. Therefore, new treatment strategies need to be developed based on a better understanding of the mechanisms underlying the developmen…
View article: Characterization of the Role of Extracellular Vesicles Released from Chicken Tracheal Cells in the Antiviral Responses against Avian Influenza Virus
Characterization of the Role of Extracellular Vesicles Released from Chicken Tracheal Cells in the Antiviral Responses against Avian Influenza Virus Open
During viral respiratory infections, the innate antiviral response engages a complex network of cells and coordinates the secretion of key antiviral factors, such as cytokines, which requires high levels of regulation and communication. Ex…
View article: Vanilloids Hamper<i>Caenorhabditis elegans</i>Response to Noxious Heat
Vanilloids Hamper<i>Caenorhabditis elegans</i>Response to Noxious Heat Open
Eugenol, a known vanilloid, was frequently used in dentistry as a local analgesic in addition, antibacterial and neuroprotective effects were also reported. Eugenol, capsaicin and many vanilloids are interacting with the transient receptor…
View article: Capsaicin and its analogues impede nocifensive response of<i>Caenorhabditis elegans</i>to noxious heat
Capsaicin and its analogues impede nocifensive response of<i>Caenorhabditis elegans</i>to noxious heat Open
Capsaicin is the most abundant pungent molecule identified in red chili peppers, and it is widely used for food flavoring, in pepper spray for self-defense devices and recently in ointments for the relief of neuropathic pain. Capsaicin and…
View article: Evaluation of upconverting nanoparticles towards heart theranostics
Evaluation of upconverting nanoparticles towards heart theranostics Open
Restricted and controlled drug delivery to the heart remains a challenge giving frequent off-target effects as well as limited retention of drugs in the heart. There is a need to develop and optimize tools to allow for improved design of d…
View article: Chromosome 14q32.2 Imprinted Region Disruption as an Alternative Molecular Diagnosis of Silver-Russell Syndrome
Chromosome 14q32.2 Imprinted Region Disruption as an Alternative Molecular Diagnosis of Silver-Russell Syndrome Open
Most patients with 14q32.2 disruption fulfill the criteria for a clinical diagnosis of SRS. These clinical data suggest similar management of patients with TS and SRS, with special attention to their young age at the onset of puberty and e…
View article: Genetic disruption of the oncogenic HMGA2–PLAG1–IGF2 pathway causes fetal growth restriction
Genetic disruption of the oncogenic HMGA2–PLAG1–IGF2 pathway causes fetal growth restriction Open
PurposeFetal growth is a complex process involving maternal, placental and fetal factors. The etiology of fetal growth retardation remains unknown in many cases. The aim of this study is to identify novel human mutations and genes related …
View article: 11p15 ICR1 Partial Deletions Associated with<i>IGF2/H19</i>DMR Hypomethylation and Silver-Russell Syndrome
11p15 ICR1 Partial Deletions Associated with<i>IGF2/H19</i>DMR Hypomethylation and Silver-Russell Syndrome Open
The 11p15 region harbors the IGF2/H19 imprinted domain, implicated in fetal and postnatal growth. Silver-Russell syndrome (SRS) is characterized by fetal and postnatal growth failure, and is caused principally by hypomethylation of the 11p…
View article: Diagnosis and management of Silver–Russell syndrome: first international consensus statement
Diagnosis and management of Silver–Russell syndrome: first international consensus statement Open
This Consensus Statement summarizes recommendations for clinical diagnosis, investigation and management of patients with Silver-Russell syndrome (SRS), an imprinting disorder that causes prenatal and postnatal growth retardation. Consider…
View article: A prospective study validating a clinical scoring system and demonstrating phenotypical-genotypical correlations in Silver-Russell syndrome
A prospective study validating a clinical scoring system and demonstrating phenotypical-genotypical correlations in Silver-Russell syndrome Open
Background Multiple clinical scoring systems have been proposed for Silver-Russell syndrome (SRS). Here we aimed to test a clinical scoring system for SRS and to analyse the correlation between (epi)genotype and phenotype. Subjects and met…