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View article: Opposite regulation of medullary pain–related projection neuron excitability in acute and chronic pain
Opposite regulation of medullary pain–related projection neuron excitability in acute and chronic pain Open
Pain hypersensitivity is associated with increased activity of peripheral and central neurons along the pain neuroaxis. We show that at the peak of acute inflammatory pain, superficial medullary dorsal horn projection neurons (PNs) that re…
View article: Adaptation of pain-related projection neurons in acute but not chronic pain
Adaptation of pain-related projection neurons in acute but not chronic pain Open
Pain hypersensitivity is associated with increased activity of peripheral and central neurons along the pain neuroaxis 1 . On the other hand, in other neuronal systems, increased activity leads to adaptive reduction of neuronal excitabilit…
View article: Author Correction: Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice
Author Correction: Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice Open
View article: Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice
Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice Open
View article: Platelet-derived growth factor activates nociceptive neurons by inhibiting M-current and contributes to inflammatory pain
Platelet-derived growth factor activates nociceptive neurons by inhibiting M-current and contributes to inflammatory pain Open
Endogenous inflammatory mediators contribute to the pathogenesis of pain by acting on nociceptors, specialized sensory neurons that detect noxious stimuli. Here, we describe a new factor mediating inflammatory pain. We show that platelet-d…
View article: <i>Pogz</i> deficiency leads to abnormal behavior, transcription dysregulation and impaired cerebellar physiology
<i>Pogz</i> deficiency leads to abnormal behavior, transcription dysregulation and impaired cerebellar physiology Open
Genes implicated in autism spectrum disorder (ASD) are enriched with chromatin regulators, but the mechanisms leading to the abnormal behavior and cognition are still unclear. Animal models are crucial for studying the effects of mutations…
View article: Corticotropin-releasing factor increases Purkinje neuron excitability by modulating sodium, potassium, and <i>I</i><sub>h</sub> currents
Corticotropin-releasing factor increases Purkinje neuron excitability by modulating sodium, potassium, and <i>I</i><sub>h</sub> currents Open
Corticotropin-releasing factor (CRF) is a neuromodulator closely associated with stress responses. It is synthesized and released in the central nervous system by various neurons, including neurons of the inferior olive. The targets of inf…