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View article: Rectal Wall Infiltration After Stabilized Hyaluronic Acid Rectal Spacer Insertion in Prostate Cancer Radiation Therapy
Rectal Wall Infiltration After Stabilized Hyaluronic Acid Rectal Spacer Insertion in Prostate Cancer Radiation Therapy Open
Purpose: Rectal spacers, such as stabilized hyaluronic acid (sHA), are used to reduce rectal radiation dose and associated toxicities. Although they have a favorable safety profile, rectal wall infiltration (RWI) can occur. The aim of this…
View article: Implantable Rectal Spacers in Prostate Cancer Radiation Therapy: A Systematic Review
Implantable Rectal Spacers in Prostate Cancer Radiation Therapy: A Systematic Review Open
The integration of IRS into clinical practice offers the potential to enhance the therapeutic landscape for patients with prostate cancer. However, its use should be guided by careful consideration of individual patient needs to determine …
View article: Method to determine the nadir PSA following partial gland ablation
Method to determine the nadir PSA following partial gland ablation Open
Objectives The objective of this study is to propose a novel method of determining the nadir PSA (nPSA) for men with prostate cancer treated by partial gland ablation (PGA). Materials and Methods Two cohorts of men were analyzed to develop…
View article: Radical cystectomy or trimodality therapy for muscle-invasive bladder cancer: a qualitative study exploring patient priorities and counselling needs when making a treatment choice
Radical cystectomy or trimodality therapy for muscle-invasive bladder cancer: a qualitative study exploring patient priorities and counselling needs when making a treatment choice Open
Background This study aims to explore the priorities and counselling needs of patients with muscle-invasive bladder cancer faced with a decision between radical cystectomy and trimodality therapy. Methods We performed a qualitative study a…
View article: Large-scale meta–genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types
Large-scale meta–genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types Open
Background This study was designed to identify common genetic susceptibility and shared genetic variants associated with acute radiation-induced toxicity across 4 cancer types (prostate, head and neck, breast, and lung). Methods A genome-w…
View article: Radiotherapy Use in Muscle-Invasive Bladder Cancer: Review of the Guidelines and Impact of Increased Awareness in Patient Referral at a Tertiary Center in Belgium
Radiotherapy Use in Muscle-Invasive Bladder Cancer: Review of the Guidelines and Impact of Increased Awareness in Patient Referral at a Tertiary Center in Belgium Open
We provide a critical overview of the RT indications in MIBC as recommended by the international guidelines. Increased awareness about RT as a treatment option in MIBC seems to have an impact on the treatment choice in clinical practice, a…
View article: A comparison of machine learning models for predicting urinary incontinence in men with localized prostate cancer
A comparison of machine learning models for predicting urinary incontinence in men with localized prostate cancer Open
Introduction Urinary incontinence (UI) is a common side effect of prostate cancer treatment, but in clinical practice, it is difficult to predict. Machine learning (ML) models have shown promising results in predicting outcomes, yet the la…
View article: Systematic review and meta-analysis of prediction models used in cervical cancer
Systematic review and meta-analysis of prediction models used in cervical cancer Open
Prediction models of cervical cancer toxicity, local or distant recurrence and survival prediction show promising results with reasonable prediction accuracy [c-index/AUC/R2 > 0.7]. These models should also be validated on external data an…
View article: Is It Safe to Switch from a Standard Anterior to Retzius-Sparing Approach in Robot-Assisted Radical Prostatectomy?
Is It Safe to Switch from a Standard Anterior to Retzius-Sparing Approach in Robot-Assisted Radical Prostatectomy? Open
Background: Retzius-sparing robot-assisted radical prostatectomy (RS-RARP) has been shown to lead to better outcomes regarding early continence compared to standard anterior RARP (SA-RARP). The goal of this study was to assess the feasibil…
View article: Development and external validation of multivariate prediction models for erectile dysfunction in men with localized prostate cancer
Development and external validation of multivariate prediction models for erectile dysfunction in men with localized prostate cancer Open
While the 10-year survival rate for localized prostate cancer patients is very good (>98%), side effects of treatment may limit quality of life significantly. Erectile dysfunction (ED) is a common burden associated with increasing age as w…
View article: Dosimetric and Hematologic Implications of Prostate-Only Versus Whole Pelvic Radiotherapy: Results of the Multicentric Phase 3 PROPER Study
Dosimetric and Hematologic Implications of Prostate-Only Versus Whole Pelvic Radiotherapy: Results of the Multicentric Phase 3 PROPER Study Open
Objectives: The aim is to evaluate the incidental dose to the lymphatic regions in prostate-only radiotherapy (PORT) and to compare hematological outcome between PORT and whole pelvic radiotherapy (WPRT) in node-positive prostate cancer (p…
View article: International consensus on radiotherapy in metastatic non-small cell lung cancer
International consensus on radiotherapy in metastatic non-small cell lung cancer Open
In the modern era, radiotherapy serves not only as a palliative tool in metastatic NSCLC, but also plays active roles in patients with oligo-focal disease, CNS metastasis and receiving ICIs.
View article: The Impact of the COVID-19 Pandemic on Bladder Cancer Care in the Netherlands
The Impact of the COVID-19 Pandemic on Bladder Cancer Care in the Netherlands Open
BACKGROUND: The COVID-19 pandemic has disrupted regular health care with potential consequences for non-COVID diseases like cancer. To ensure continuity of oncological care, guidelines were temporarily adapted. OBJECTIVE: To evaluate the i…
View article: Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Is Associated with Improved Oncological Outcome in Men Treated with Salvage Radiation Therapy for Biochemically Recurrent Prostate Cancer
Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Is Associated with Improved Oncological Outcome in Men Treated with Salvage Radiation Therapy for Biochemically Recurrent Prostate Cancer Open
Performing prostate-specific membrane antigen positron emission tomography/computed tomography imaging in patients with biochemical recurrence of disease after robot-assisted radical prostatectomy, before initiating salvage radiation thera…
View article: Evaluation of hyaluronic acid gel dissolution with hyaluronidase in an in-vitro prostate cancer model
Evaluation of hyaluronic acid gel dissolution with hyaluronidase in an in-vitro prostate cancer model Open
A dose response was observed by HAS injection: highest volumes of HAS dissolute most swiftly. Using a ratio of HA:HAS of 1:2 results in a decrease to half of initial volume within 24 h. This is of special interest when used in clinical pra…
View article: Impact of the COVID-19 outbreak on prostate cancer care in the Netherlands
Impact of the COVID-19 outbreak on prostate cancer care in the Netherlands Open
During the first COVID-19 wave the number of prostate cancer diagnoses declined. In the second half of 2020 this largely restored although the number remained lower than expected. Changes in treatment were temporary and compliant with adap…
View article: Impact of Advanced Radiotherapy on Second Primary Cancer Risk in Prostate Cancer Survivors: A Nationwide Cohort Study
Impact of Advanced Radiotherapy on Second Primary Cancer Risk in Prostate Cancer Survivors: A Nationwide Cohort Study Open
Purpose External Beam Radiotherapy (EBRT) techniques dramatically changed over the years. This may have affected the risk of radiation-induced second primary cancers (SPC), due to increased irradiated low dose volumes and scatter radiation…