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View article: Rhapontin activates nuclear factor erythroid 2-related factor 2 to ameliorate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced gastrointestinal dysfunction in Parkinson's disease mice
Rhapontin activates nuclear factor erythroid 2-related factor 2 to ameliorate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced gastrointestinal dysfunction in Parkinson's disease mice Open
BACKGROUND Parkinson's disease (PD)-a progressive neurodegenerative disorder-is characterized by motor and gastrointestinal dysfunction. The exploration of novel therapeutic strategies for PD is vital. AIM To investigate the potential mech…
View article: Integrating Network Pharmacology, Transcriptomics to Reveal Neuroprotective of Curcumin Activate PI3K / AKT Pathway in Parkinson’s Disease
Integrating Network Pharmacology, Transcriptomics to Reveal Neuroprotective of Curcumin Activate PI3K / AKT Pathway in Parkinson’s Disease Open
In conclusion, the neuroprotective mechanisms of curcumin activate PI3K / AKT pathway in Parkinson's disease was revealed by our study.
View article: Curcumin alleviates 1-methyl- 4-phenyl- 1,2,3,6-tetrahydropyridine- induced Parkinson’s disease in mice via modulating gut microbiota and short-chain fatty acids
Curcumin alleviates 1-methyl- 4-phenyl- 1,2,3,6-tetrahydropyridine- induced Parkinson’s disease in mice via modulating gut microbiota and short-chain fatty acids Open
Background: The microbiota–gut–brain axis has been proposed as a potential therapeutic target of PD. The effects of curcumin against Parkinson’s disease have been demonstrated; however, its neuroprotective mechanisms remain unknown. Our st…
View article: Genotype and clinical phenotype analysis of a Family with Kennedy disease
Genotype and clinical phenotype analysis of a Family with Kennedy disease Open
To investigate the clinical phenotype-genotype correlations of a family with Kennedy disease (KD) and improve our understanding of the disease. KD was confirmed after clinical phenotypic analyses, laboratory tests, polymerase chain reactio…
View article: <i>δ</i>‐Opioid Receptor Activation Inhibits Ferroptosis by Activating the Nrf2 Pathway in MPTP‐Induced Parkinson Disease Models
<i>δ</i>‐Opioid Receptor Activation Inhibits Ferroptosis by Activating the Nrf2 Pathway in MPTP‐Induced Parkinson Disease Models Open
Introduction . Recent studies suggest the involvement of ferroptosis in the pathogenesis of Parkinson disease (PD). δ ‐Opioid receptors (DORs) have neuroprotective effects in PD. It is not known whether the neuroprotective effects of DORs …
View article: Exploring the Neuroprotective Mechanism of Curcumin Inhibition of Intestinal Inflammation against Parkinson’s Disease Based on the Gut-Brain Axis
Exploring the Neuroprotective Mechanism of Curcumin Inhibition of Intestinal Inflammation against Parkinson’s Disease Based on the Gut-Brain Axis Open
Parkinson’s disease (PD) is a chronic progressive neurodegenerative disease commonly seen in aged people, in which gastrointestinal dysfunction is the most common nonmotor symptom and the activation of the gut–brain axis by intestinal infl…
View article: PI3K polymorphism in patients with sporadic Parkinson’s disease
PI3K polymorphism in patients with sporadic Parkinson’s disease Open
Parkinson’s disease (PD) is a common irreversible neurodegenerative disease associated with cognitive impairment. To investigate the serum level of phosphatidylinositol-3-kinase (PI3K) and the distribution of the genotypes and alleles of 3…
View article: Interactive Responses of Enkephalin, δ-opioid Receptor and Dopamine Receptor D1/D2 to Hypoxia and/or MPP+ Stress in PC12 Cells
Interactive Responses of Enkephalin, δ-opioid Receptor and Dopamine Receptor D1/D2 to Hypoxia and/or MPP+ Stress in PC12 Cells Open
Hypoxic/ischemic brain injury is a potential etiology of Parkinson’s disease (PD). There is evidence suggesting that the up-regulation of enkephalin, an endogenous opioid, in the midbrain may have a compensatory effect against Parkinson’s …
View article: Genotype and Clinical Phenotype Analysis of a Family of Kennedy Disease
Genotype and Clinical Phenotype Analysis of a Family of Kennedy Disease Open
Objective: By analyzing the clinical phenotype, genotype and family characteristics of a Kennedy disease family, to explore the clinical and genetic characteristics of the family, and to further improve the understanding of the disease. An…