Benedetta Ferrara
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View article: The nucleolin antagonist N6L and paclitaxel combination treatment could be a new promising therapeutic strategy for pancreatic ductal adenocarcinoma therapy
The nucleolin antagonist N6L and paclitaxel combination treatment could be a new promising therapeutic strategy for pancreatic ductal adenocarcinoma therapy Open
Pancreatic cancer (PCa) is one of the most devastating cancers with few clinical signs and no truly effective therapy. In recent years, our team has demonstrated that nucleolin antagonists such as N6L could be a therapeutic alternative for…
View article: Matrix stiffness regulates the protein profile of extracellular vesicles of pancreatic cancer cell lines
Matrix stiffness regulates the protein profile of extracellular vesicles of pancreatic cancer cell lines Open
The fibrotic stroma characterizing pancreatic ductal adenocarcinoma (PDAC) derives from a progressive tissue rigidification, which induces epithelial mesenchymal transition and metastatic dissemination. The aim of this study was to investi…
View article: Establishment of a Transplantation Model of PDAC-Derived Liver Metastases
Establishment of a Transplantation Model of PDAC-Derived Liver Metastases Open
Background The highly metastatic nature of pancreatic ductal adenocarcinoma (PDAC) and the difficulty to achieve favorable patient outcomes emphasize the need for novel therapeutic solutions. For preclinical evaluations, genetically engine…
View article: A stapled chromogranin A-derived peptide homes in on tumors that express αvβ6 or αvβ8 integrins
A stapled chromogranin A-derived peptide homes in on tumors that express αvβ6 or αvβ8 integrins Open
Rationale: The αvβ6- and αvβ8-integrins, two cell-adhesion receptors upregulated in many tumors and involved in the activation of the latency associated peptide (LAP)/TGFβ complex, represent potential targets for tumor imaging and therapy.…
View article: A Comprehensive Characterization of Stemness in Cell Lines and Primary Cells of Pancreatic Ductal Adenocarcinoma
A Comprehensive Characterization of Stemness in Cell Lines and Primary Cells of Pancreatic Ductal Adenocarcinoma Open
The aim of this study is to provide a comprehensive characterization of stemness in pancreatic ductal adenocarcinoma (PDAC) cell lines. Seventeen cell lines were evaluated for the expression of cancer stem cell (CSC) markers. The two putat…
View article: The Extracellular Matrix in Pancreatic Cancer: Description of a Complex Network and Promising Therapeutic Options
The Extracellular Matrix in Pancreatic Cancer: Description of a Complex Network and Promising Therapeutic Options Open
The stroma is a relevant player in driving and supporting the progression of pancreatic ductal adenocarcinoma (PDAC), and a large body of evidence highlights its role in hindering the efficacy of current therapies. In fact, the dense extra…
View article: Cell surface nucleolin as active bait for nanomedicine in cancer therapy: a promising option
Cell surface nucleolin as active bait for nanomedicine in cancer therapy: a promising option Open
Conventional chemotherapy used against cancer is mostly limited due to their non-targeted nature, affecting normal tissue and causing undesirable toxic effects to the affected tissue. With the aim of improving these treatments both therape…
View article: The extracellular matrix in pancreatic cancer: description of a complex network and promising therapeutic options
The extracellular matrix in pancreatic cancer: description of a complex network and promising therapeutic options Open
International audience
View article: Improvement in the Anti-Tumor Efficacy of Doxorubicin Nanosponges in In Vitro and in Mice Bearing Breast Tumor Models
Improvement in the Anti-Tumor Efficacy of Doxorubicin Nanosponges in In Vitro and in Mice Bearing Breast Tumor Models Open
Doxorubicin (DOX) is an anthracycline widely used in cancer therapy and in particular in breast cancer treatment. The treatment with DOX appears successful, but it is limited by a severe cardiotoxicity. This work evaluated the in vitro and…
View article: Paclitaxel-Loaded Nanosponges Inhibit Growth and Angiogenesis in Melanoma Cell Models
Paclitaxel-Loaded Nanosponges Inhibit Growth and Angiogenesis in Melanoma Cell Models Open
This study investigated the effects of free paclitaxel (PTX) and PTX-loaded in pyromellitic nanosponges (PTX-PNS) in reducing in vitro and in vivo melanoma cell growth and invasivity, and in inhibiting angiogenesis. To test the response of…
View article: Design of mesoscopic photonic crystal waveguides
Design of mesoscopic photonic crystal waveguides Open
The authors numerically analyse the performance of a mesoscopic photonic crystal (MPhC) waveguide that could be exploited to develop a new class of routing elements and a cascadable circuitry taking advantage of the spatial and spectral re…
View article: Development of Solid Lipid Nanoparticles by Cold Dilution of Microemulsions: Curcumin Loading, Preliminary In Vitro Studies, and Biodistribution
Development of Solid Lipid Nanoparticles by Cold Dilution of Microemulsions: Curcumin Loading, Preliminary In Vitro Studies, and Biodistribution Open
Background: Solid lipid nanoparticles (SLNs) are attractive drug delivery systems for lipophilic molecules like curcumin (CURC) with low chemical stability. Methods: A simple, innovative, and cold-operating method, named “cold dilution of …
View article: Glutathione/pH-responsive nanosponges enhance strigolactone delivery to prostate cancer cells
Glutathione/pH-responsive nanosponges enhance strigolactone delivery to prostate cancer cells Open
Strigolactones (SLs) are carotenoid-derived plant hormones that exhibit anti-cancer activities. We previously demonstrated that two SL analogues, MEB55 and ST362, inhibit the growth and survival of various cancer cell lines. However, these…
View article: Solid Lipid Nanoparticles Carrying Temozolomide for Melanoma Treatment. Preliminary In Vitro and In Vivo Studies
Solid Lipid Nanoparticles Carrying Temozolomide for Melanoma Treatment. Preliminary In Vitro and In Vivo Studies Open
Aim: To develop an innovative delivery system for temozolomide (TMZ) in solid lipid nanoparticles (SLN), which has been preliminarily investigated for the treatment of melanoma. Materials and Methods: SLN-TMZ was obtained through fatty aci…
View article: Full optical confinement in 1D mesoscopic photonic crystal-based microcavities: an experimental demonstration
Full optical confinement in 1D mesoscopic photonic crystal-based microcavities: an experimental demonstration Open
International audience
View article: Cyclodextrin-Based Nanohydrogels Containing Polyamidoamine Units: A New Dexamethasone Delivery System for Inflammatory Diseases
Cyclodextrin-Based Nanohydrogels Containing Polyamidoamine Units: A New Dexamethasone Delivery System for Inflammatory Diseases Open
Glucocorticoids are widely prescribed in treatment of rheumatoid arthritis, asthma, systemic lupus erythematosus, lymphoid neoplasia, skin and eye inflammations. However, well-documented adverse effects offset their therapeutic advantages.…
View article: Enhanced cytotoxic effect of camptothecin nanosponges in anaplastic thyroid cancer cells <i>in vitro</i> and <i>in vivo</i> on orthotopic xenograft tumors
Enhanced cytotoxic effect of camptothecin nanosponges in anaplastic thyroid cancer cells <i>in vitro</i> and <i>in vivo</i> on orthotopic xenograft tumors Open
Anaplastic carcinoma of the thyroid (ATC) is a lethal human malignant cancer with median survival of 6 months. To date, no treatment has substantially changed its course, which makes urgent need for the development of novel drugs or novel …
View article: Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an<i>in vivo</i>model
Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an<i>in vivo</i>model Open
Our results indicate that the co-administration of dexamethasone and butyrate by nanoparticles may be beneficial for inflammatory bowel disease treatment.
View article: Enhanced cytotoxic effect of camptothecin nanosponges in anaplastic thyroid cancer cells <i>in vitro</i> and <i>in vivo</i> on orthotopic xenograft tumors
Enhanced cytotoxic effect of camptothecin nanosponges in anaplastic thyroid cancer cells <i>in vitro</i> and <i>in vivo</i> on orthotopic xenograft tumors Open
Anaplastic carcinoma of the thyroid (ATC) is a lethal human malignant cancer with median survival of 6 months. To date, no treatment has substantially changed its course, which makes urgent need for the development of novel drugs or novel …
View article: Drug Delivery Nanoparticles in Treating Chemoresistant Tumor Cells
Drug Delivery Nanoparticles in Treating Chemoresistant Tumor Cells Open
Intrinsic or acquired chemoresistance represents the main obstacle to the successful treatment of cancer patients. Several mechanisms are involved in multidrug resistance: decreased uptake of hydrophilic drugs, increase of energy dependent…
View article: Solid lipid nanoparticles carrying lipophilic derivatives of doxorubicin: preparation, characterization, and<i>in vitro</i>cytotoxicity studies
Solid lipid nanoparticles carrying lipophilic derivatives of doxorubicin: preparation, characterization, and<i>in vitro</i>cytotoxicity studies Open
Doxorubicin (DOXO) lauroyl ester and amide were proposed as lipophilic derivatives and entrapped in SLNs. DOXO derivatives-loaded SLNs were spherical shaped, had 200-300 nm mean diameters and showed 80-94% w/w drug entrapment efficiencies.…
View article: Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells<i>In Vitro</i>and Mouse Experimental Autoimmune Encephalomyelitis<i>In Vivo</i>
Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells<i>In Vitro</i>and Mouse Experimental Autoimmune Encephalomyelitis<i>In Vivo</i> Open
Osteopontin is a proinflammatory cytokine and plays a pathogenetic role in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), by recruiting autoreactive T cells into the central nervous system. Osteop…