Benedict Abdon
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Functionally diversified BiP orthologs control body growth, reproduction, stress resistance, aging, and ER-Phagy in <i>Caenorhabditis elegans</i> Open
Cellular systems that govern protein folding rely on a delicate balance of functional redundancy and diversification to maintain protein homeostasis (proteostasis). Here, we use Caenorhabditis elegans to demonstrate how both overlapping an…
Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism Open
The growth of skeletal muscle relies on a delicate equilibrium between protein synthesis and degradation; however, how proteostasis is managed in the endoplasmic reticulum (ER) is largely unknown. Here, we report that the SEL1L-HRD1 ER-ass…
The Role of Endoplasmic Reticulum Associated Degradation in Skeletal Muscle Growth and Metabolism Open
The endoplasmic reticulum (ER) is a specialized organelle optimized for the synthesis and maturation of transmembrane and secretory proteins. Under cellular or environmental stress, proteins in the ER may misfold or aggregate, jeopardizing…
Divergent mechanisms for regulating growth and development after imaginal disc damage in the tobacco hornworm, <i>Manduca sexta</i> Open
Holometabolous insects have been able to radiate to vast ecological niches as adults through the evolution of adult-specific structures such as wings, antennae and eyes. These structures arise from imaginal discs that show regenerative cap…