Explanipedia

Contributors for Volume 1 Open

Zaigham Abbas, Khalid Abdullah, Subrat Kumar Acharya, Gulnara Aghayeva, Jawad Ahmad , et al. · 2024

Confounding Factors in the Association Between Glucagon-Like Peptide-1 Receptor Agonist Use and Retained Gastric Contents in Asymptomatic Patients Undergoing Upper Gastrointestinal Endoscopy: A Retrospective Study Open

Thomas A Elimihele, Anjali M Mangrola, Oluwatobi Oshomoji, N. Wilson, Ikenna Nnamani , et al. · 2024

The Non-Invasive Prediction of Colorectal Neoplasia (NIPCON) Study 1995–2022: A Comparison of Guaiac-Based Fecal Occult Blood Test (FOBT) and an Anti-Adenoma Antibody, Adnab-9 Open

Martin Tobi, Fadi Antaki, Mary Ann Rambus, Yu‐Xiao Yang, David E. Kaplan , et al. · 2023

Given the need to improve the sensitivity of non-invasive methods to detect colorectal neoplasia, particularly adenomas, we compared a fecal test using a monoclonal antibody (Mab) raised against constituents of colonic adenomas designated …

Post-endoscopic Retrograde Cholangiopancreatography Complications: A Case of Duodenal Perforation and Literature Review Open

Rabira R Dufera, Tamiru B. Berake, Benedict Maliakkal · 2023

A duodenal perforation is a serious complication that can occur during endoscopic retrograde cholangiopancreatography (ERCP), particularly if it is associated with therapeutic endoscopic sphincterotomy. Therefore, it is crucial to identify…

Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review Open

Ikenna Nnamani, Oluwaremilekun Tolu-Akinnawo, Rabira R Dufera, Akintomiwa Akintunde, Benedict Maliakkal · 2023

Tinospora cordifolia (Guduchi/Giloy) is a relatively common herbal supplement whose use has recently become prominent in Southeast Asia. It was promoted to the public in India as an immunity booster, especially against the novel COV…

Colovesical Fistula Complicating the First Symptomatic Episode of Acute Diverticulitis in a Young Adult Open

Rabira R Dufera, Oluwaremilekun Tolu-Akinnawo, Benedict Maliakkal · 2023

Colovesical fistula is one of the known complications of acute diverticulitis. However, it is uncommon for a patient to present with a colovesical fistula without prior episodes of diverticulitis. In this case, we report a patient with acu…

Budd-Chiari Syndrome as an Initial Presentation of Non-Promyelocytic Acute Myelogenous Leukemia Open

Jiten P. Kothadia, Vanisha Patel, Rajiv Heda, Wesley A. Angel, Vishwas Vanar , et al. · 2022

Budd-Chiari syndrome (BCS) is a rare disease characterized by hepatic venous outflow tract obstruction, frequently due to an underlying thrombophilic disorder. Acute myeloid leukemia rarely presents as acute BCS due to hyperfibrinolysis, h…

Prognosis of hospitalized patients with cirrhosis and acute kidney disease Open

Florence Wong, Guadalupe García–Tsao, K. Rajender Reddy, Jacqueline G. O’Leary, Patrick S. Kamath , et al. · 2022

Background The prognosis of acute kidney disease (AKD), defined as a glomerular filtration rate of <60 ml/min/1.73 m 2 or a rise in serum creatinine (sCr) of <50% for <3 months, is not clearly known. Aim To study the prevalence, predictive…

New onset diabetes mellitus after liver transplantation Open

Benedict Maliakkal, Sanjaya K. Satapathy · 2021

Acute Hepatitis A Causing Severe Hemolysis and Renal Failure in Undiagnosed Glucose-6-Phosphate Dehydrogenase Deficient Patient: A Case Report and Review of the Literature Open

Iman Abutineh, Kyle Kreitman, Jiten P. Kothadia, Bilal Ali, Richa Jain , et al. · 2021

Infection with hepatitis A virus is usually a self-limited illness that rarely results in fulminant liver failure. Severe hemolysis is an uncommon complication but has been reported in patients with glucose-6-phosphate dehydrogenase (G6PD)…

Increased Risk of ACLF and Inpatient Mortality in Hospitalized Patients with Cirrhosis and Hepatic Hydrothorax Open

Jacqueline G. O’Leary, K. Rajender Reddy, Puneeta Tandon, Scott W. Biggins, Florence Wong , et al. · 2020

Safety profile of boceprevir and telaprevir in chronic hepatitis C: Real world experience from HCV-TARGET Open

Stuart C. Gordon, Andrew J. Muir, Joseph K. Lim, Brian L. Pearlman, Curtis K. Argo , et al. · 2020

The safety profiles of boceprevir and telaprevir in the treatment of chronic hepatitis C, administered in academic and community centres across the United States, were evaluated.

Stage 1b acute kidney injury in cirrhosis is likely due to underlying chronic kidney disease and would be more appropriately re-classified as acute-on-chronic kidney disease Open

F. Susan Wong, K. Rajender Reddy, Puneeta Tandon, Jacqueline G. O’Leary, Scott W. Biggins , et al. · 2020

Longitudinal Renal Function in Liver Transplant Recipients With Acute-on-Chronic Liver Failure Open

Masahiko Yazawa, Benedict Maliakkal, Satheesh Nair, Pradeep S. B. Podila, Uchenna A. Agbim , et al. · 2020

INTRODUCTION: To analyze the impact of acute-on-chronic liver failure (ACLF) immediately before liver transplantation (LT) on short-term kidney function. METHODS: In this retrospective study, we included 416 of 687 consecutive patients who…

A pilot study of ex-vivo MRI-PDFF of donor livers for assessment of steatosis and predicting early graft dysfunction Open

Sanjaya K. Satapathy, Humberto C. González, Jason M. Vanatta, Andrew Dyer, Wesley Angel , et al. · 2020

In this pilot study, MRI-PDFF imaging showed potential utility in quantifying hepatic steatosis ex-vivo donor liver evaluation and the ability to predict EAD related to severe allograft steatosis in the recipient.

Accuracy of Noninvasive Fibrosis Scoring Systems in African American and White Patients With Nonalcoholic Fatty Liver Disease Open

Hemnishil K. Marella, Yala Kirthi Reddy, Yu Jiang, Surosree Ganguli, Pradeep S. B. Podila , et al. · 2020

OBJECTIVES: Nonalcoholic fatty liver disease fibrosis score (NFS), fibrosis-4 (FIB-4) score, aspartate aminotransferase (AST)-to-platelet ratio index (APRI) score, and AST–alanine aminotransferase (ALT) ratio are noninvasive fibrosis scori…

Outcomes of Liver Transplant Recipients With Acute-on-Chronic Liver Failure Based on EASL-CLIF Consortium Definition: A Single-center Study Open

Uchenna Agbim, Anuj Sharma, Benedict Maliakkal, Saradasri Karri, Masahiko Yazawa , et al. · 2020

Background. The impact of acute-on-chronic liver failure (ACLF) defined by European Association for the Study of the Liver-Chronic Liver Failure in liver transplant (LT) recipients has not been well characterized. The aim of the study was …

Pathogenesis of non-alcoholic fatty liver disease and implications on cardiovascular outcomes in liver transplantation Open

Benedict Maliakkal · 2020

Along with the obesity epidemic there has been a major increase in non-alcoholic fatty liver disease (NAFLD) prevalence, paralleling a steady increase in cirrhosis of the liver and hepatocellular cancer (HCC) related to NAFLD. Currently, N…

Hyperammonemic encephalopathy associated with 5-fluorouracil in a patient with previous orthotopic liver transplantation Open

Hemnishil K. Marella, Rahul Peravali, Amit Jain, Satheesh Nair, Benedict Maliakkal , et al. · 2020

5-Fluorouracil (5-FU)-based chemotherapy is the most common regimen used to treat metastatic or advanced colon cancer. Neurotoxicity is a rare but serious adverse effect of 5-FU-based therapy. We report an unusual case of 5-FU-induced hype…

Supplementary Material for: Lack of Association between Pretransplant Donor-Specific Antibodies and Posttransplant Kidney Outcomes in Simultaneous Liver-Kidney Transplant Recipients with Rabbit Anti-Thymocyte Globulin Induction and Steroid-Free Protocol Open

Masahiko Yazawa, Orsolya Cseprekál, Ryan A. Helmick, Manish Talwar, Vasanthi Balaraman , et al. · 2020

Introduction and Objective: The impact of pretransplant donor-specific antibodies (DSAs), especially class II DSAs, on kidney allograft outcomes remains unclear in simultaneous liver-kidney transplantation (SLKT) recipients. …

Factors associated with hepatitis C antibody seroconversion after transplantation of kidneys from hepatitis C infected donors to hepatitis C naïve recipients Open

Uchenna Agbim, Orsolya Cseprekál, Masahiko Yazawa, Manish Talwar, Vasanthi Balaraman , et al. · 2020

HCV antibody should not be considered routine screening for presence of infection in previously HCV naïve kidney transplant recipients receiving kidneys from HCV-infected donors, as only a modest percentage have antibody despite active vir…

Association between post‐transplant donor‐specific antibodies and recipient outcomes in simultaneous liver–kidney transplant recipients: single‐center, cohort study Open

Masahiko Yazawa, Orsolya Cseprekál, Ryan A. Helmick, Manish Talwar, Vasanthi Balaraman , et al. · 2019

There is a dearth of published data regarding the presence of post-transplant donor-specific antibodies (DSA), especially C1q-binding DSA (C1q+DSA), and patient and kidney allograft outcomes in simultaneous liver-kidney transplant (SLKT) r…

Transplantation of kidneys from hepatitis C–infected donors to hepatitis C–negative recipients: Single center experience Open

Miklos Z. Molnar, Satheesh Nair, Orsolya Cseprekál, Masahiko Yazawa, Manish Talwar , et al. · 2019

Our aim was to evaluate the safety of transplanting kidneys from HCV-infected donors in HCV-uninfected recipients. Data collected from 53 recipients in a single center, observational study included donor and recipient characteristics, live…

Natural History of Non-Alcoholic Fatty Liver Disease: A Study With Paired Liver Biopsies Open

Yala Kirthi Reddy, Hemnishil K. Marella, Yu Jiang, Surosree Ganguli, Peter D. Snell , et al. · 2019

Nosocomial Infections Are Frequent and Negatively Impact Outcomes in Hospitalized Patients With Cirrhosis Open

Jasmohan S. Bajaj, Jacqueline G. O’Leary, Puneeta Tandon, Florence Wong, Guadalupe García–Tsao , et al. · 2019

OBJECTIVES: Nosocomial infections (NIs) can be a major cause of morbidity and mortality in cirrhosis. This study aims to define the determinants of NI development and its impact on 30-day outcomes among hospitalized patients with cirrhosis…

Pre-Operative Delta-MELD is an Independent Predictor of Higher Mortality following Liver Transplantation Open

George Cholankeril, Andrew A. Li, Brittany B. Dennis, Chiranjeevi Gadiparthi, Donghee Kim , et al. · 2019

Clinical decompensation immediately prior to liver transplantation may affect post-liver transplant (LT) outcomes. Using the serial Model for End-Stage Liver Disease (MELD) scores recorded in the United Network for Organ Sharing national r…

Targets to improve quality of care for patients with hepatic encephalopathy: data from a multi‐centre cohort Open

Jasmohan S. Bajaj, Jacqueline G. O’Leary, Puneeta Tandon, Florence Wong, Patrick S. Kamath , et al. · 2019

Summary Background Hepatic encephalopathy (HE) can adversely affect outcomes in both in‐patients and out‐patients with cirrhosis. Aim To define targets for improving quality of care in HE management in the multi‐centre North American Conso…

Impact of Chronic Kidney Disease on Outcomes in Cirrhosis Open

Florence Wong, K. Rajender Reddy, Jacqueline G. O’Leary, Puneeta Tandon, Scott W. Biggins , et al. · 2019

We hypothesize that the prevalence of chronic kidney disease (CKD) among patients with cirrhosis has increased due to the increased prevalence of CKD‐associated comorbidities, such as diabetes. We aimed to assess the characteristics of hos…

Outcomes After Listing for Liver Transplant in Patients With Acute‐on‐Chronic Liver Failure: The Multicenter North American Consortium for the Study of End‐Stage Liver Disease Experience Open

Jacqueline G. O’Leary, Jasmohan S. Bajaj, Puneeta Tandon, Scott W. Biggins, Florence Wong , et al. · 2019

Acute‐on‐chronic liver failure (ACLF) characterized with ≥2 extrahepatic organ failures in cirrhosis carries a high mortality. Outcomes of patients listed for liver transplantation (LT) after ACLF and after LT are largely unknown. The Nort…

IDDF2018-ABS-0111 Safety and efficacy of treatment with once-daily LEDIPASVIR/SOFOSBUVIR (90/400 MG) for 12 weeks in genotype 1 hcv-infected patients with severe renal impairment Open

Eric Lawitz, Charles Landis, Benedict Maliakkal, Maurizio Bonacini, Grisell Ortiz‐Lasanta , et al. · 2018

Background Despite higher concentrations of the primary circulating sofosbuvir (SOF) metabolite, GS-331007, in patients with severe renal impairment (RI), retrospective case series and claims database analyses have suggested substantial us…

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