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View article: International Validation of the Immunoscore Biopsy in Patients With Rectal Cancer Managed by a Watch-and-Wait Strategy
International Validation of the Immunoscore Biopsy in Patients With Rectal Cancer Managed by a Watch-and-Wait Strategy Open
PURPOSE No biomarker capable of improving selection and monitoring of patients with rectal cancer managed by watch-and-wait (W&W) strategy is currently available. Prognostic performance of the Immunoscore biopsy (IS B ) was recently sugges…
View article: Multi-Institutional Evaluation of Pathologists’ Assessment Compared to Immunoscore
Multi-Institutional Evaluation of Pathologists’ Assessment Compared to Immunoscore Open
Background: The Immunoscore (IS) is a quantitative digital pathology assay that evaluates the immune response in cancer patients. This study reports on the reproducibility of pathologists’ visual assessment of CD3+- and CD8+-stained colon …
Supplementary Figure and Tables legends from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Legends for supplementary figure and trables
Supplementary Table 3 from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Samples from the Cancer Cell Line Encyclopedia
Supplementary Table 6 from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Levels of expression of genes related to inflammation, angiogenesis and immunomodulation in CRC cohorts
Data from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Purpose: The tumor microenvironment is formed by many distinct and interacting cell populations, and its composition may predict patients' prognosis and response to therapies. Colorectal cancer is a heterogeneous disease in which immune cl…
Supplementary Figure S1 from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Supplementary Figure 1 : Design and use of the Microenvironment Cell Populations (MCP)-counter algorithm a) Heatmap representation of the expression of selected transcriptomic markers underlying MCP-counter scores in transcriptomic profile…
Supplementary Tables 1-3, Supplementary Figures 1-14 from Tumor-Infiltrating and Peripheral Blood T-cell Immunophenotypes Predict Early Relapse in Localized Clear Cell Renal Cell Carcinoma Open
Table S1. Demographic and clinical characteristics of the analyzed patients; Table S2. Antibodies and conditions used for the IHC studies; Table S3. List of immune-related genes analyzed by Low Density Array; Figure S1. Gating and data ana…
Supplementary Table 4 from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Antibodies used for immunohistochemical analyses
Supplementary Table 1 from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Immune, and other stromal samples analyzed
Supplementary Tables 1-3, Supplementary Figures 1-14 from Tumor-Infiltrating and Peripheral Blood T-cell Immunophenotypes Predict Early Relapse in Localized Clear Cell Renal Cell Carcinoma Open
Table S1. Demographic and clinical characteristics of the analyzed patients; Table S2. Antibodies and conditions used for the IHC studies; Table S3. List of immune-related genes analyzed by Low Density Array; Figure S1. Gating and data ana…
Supplementary Table 5 from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Consensus Molecular Subgroup-level statistics on each MCP-counter abundance estimates
Supplementary Table 2 from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Colorectal cancer samples constituting the 3 cohorts analyzed, along with their molecular subgroups
Supplementary Table 1 from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Immune, and other stromal samples analyzed
Supplementary Table 2 from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Colorectal cancer samples constituting the 3 cohorts analyzed, along with their molecular subgroups
Data from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Purpose: The tumor microenvironment is formed by many distinct and interacting cell populations, and its composition may predict patients' prognosis and response to therapies. Colorectal cancer is a heterogeneous disease in which immune cl…
Data from Tumor-Infiltrating and Peripheral Blood T-cell Immunophenotypes Predict Early Relapse in Localized Clear Cell Renal Cell Carcinoma Open
Purpose: The efficacy of PD-1 checkpoint blockade as adjuvant therapy in localized clear cell renal cell carcinoma (ccRCC) is currently unknown. The identification of tumor microenvironment (TME) prognostic biomarkers in this setting may h…
Supplementary Figure S1 from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Supplementary Figure 1 : Design and use of the Microenvironment Cell Populations (MCP)-counter algorithm a) Heatmap representation of the expression of selected transcriptomic markers underlying MCP-counter scores in transcriptomic profile…
Data from Tumor-Infiltrating and Peripheral Blood T-cell Immunophenotypes Predict Early Relapse in Localized Clear Cell Renal Cell Carcinoma Open
Purpose: The efficacy of PD-1 checkpoint blockade as adjuvant therapy in localized clear cell renal cell carcinoma (ccRCC) is currently unknown. The identification of tumor microenvironment (TME) prognostic biomarkers in this setting may h…
Supplementary Table 4 from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Antibodies used for immunohistochemical analyses
Supplementary Table 6 from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Levels of expression of genes related to inflammation, angiogenesis and immunomodulation in CRC cohorts
Supplementary Figure and Tables legends from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Legends for supplementary figure and trables
Supplementary Table 5 from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Consensus Molecular Subgroup-level statistics on each MCP-counter abundance estimates
Supplementary Table 3 from Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy Open
Samples from the Cancer Cell Line Encyclopedia
View article: Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer
Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer Open
Background: The prognostic value of Immunoscore was evaluated in Stage II/III colon cancer (CC) patients, but it remains unclear in Stage I/II, and in early-stage subgroups at risk. An international Society for Immunotherapy of Cancer (SIT…
View article: Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study
Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study Open
BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I–III colon cancer (CC) in the Asian population. These patients were originally included in an international study led by the Society for Im…
Caractérisation des lymphocytes T gamma delta et de l'expression de BTN3A dans le cancer colorectal Open
Γδ T cells are a sub-population of T cells, with innate and adaptive immunity functions. They are activated via a non-MHC Class I antigen presentation and have a potential anti-tumoral activity. Indeed, the human Vγ9Vδ2 T cells recognize a…
Tissue-resident FOLR2<sup>+</sup>macrophages associate with tumor-infiltrating CD8<sup>+</sup>T cells and with increased survival of breast cancer patients Open
SUMMARY Macrophage infiltration is a hallmark of solid cancers and overall macrophage infiltration is correlated with lower patient survival and resistance to therapy. However, tumor-associated macrophages are phenotypically and functional…
Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer Open
PURPOSE The purpose of this study was to evaluate the prognostic value of Immunoscore in patients with stage III colon cancer (CC) and to analyze its association with the effect of chemotherapy on time to recurrence (TTR). METHODS An inter…