Bénédicte Lebrun‐Vignes
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View article: Comedications Associated with Immune‐Related Adverse Events from Immune‐Checkpoint Inhibitors
Comedications Associated with Immune‐Related Adverse Events from Immune‐Checkpoint Inhibitors Open
Immune‐checkpoint inhibitors (ICI) have revolutionized cancer treatment but are responsible for various immune‐related adverse events (irAE). The impact of non‐anticancer medications (comedications) on irAE occurrence remains largely unexp…
View article: French national protocol for diagnosis and management of drug reaction with eosinophilia and systemic symptoms (DRESS) in adults and children
French national protocol for diagnosis and management of drug reaction with eosinophilia and systemic symptoms (DRESS) in adults and children Open
International audience
View article: Adherence patterns and their determinants among oral isotretinoin initiators
Adherence patterns and their determinants among oral isotretinoin initiators Open
International audience
View article: Clinical and radiological pattern of olaparib-induced interstitial lung disease
Clinical and radiological pattern of olaparib-induced interstitial lung disease Open
CEPRO #2023-010.
View article: Clinical and radiological pattern of olaparib- induced interstitial lung disease
Clinical and radiological pattern of olaparib- induced interstitial lung disease Open
Background:PARP inhibitors (PARPi) are used in the treatment of ovarian, breast, pancreatic, and prostate cancers. Pneumonitis has been identified as a potential side effect, with a higher meta-analysis-assessed risk for olaparib versus ot…
View article: French national protocol for diagnosis and management of epidermal necrolysis in adults (Stevens-Johnson syndrome and toxic epidermal necrolysis)
French national protocol for diagnosis and management of epidermal necrolysis in adults (Stevens-Johnson syndrome and toxic epidermal necrolysis) Open
View article: Compliance with the pregnancy prevention program among women initiating isotretinoin treatment between 2014 and 2021: A nationwide cohort study on the French Health Data System (<scp>SNDS</scp>)
Compliance with the pregnancy prevention program among women initiating isotretinoin treatment between 2014 and 2021: A nationwide cohort study on the French Health Data System (<span>SNDS</span>) Open
Background Despite the French pregnancy prevention program (PPP), a considerable number of pregnancies are potentially exposed to oral isotretinoin. New measures were taken by the French Medicines Agency, including the restriction of initi…
View article: Evolution of the spectrum of drugs associated with acute generalized exanthematous pustulosis over time: A pharmacovigilance study
Evolution of the spectrum of drugs associated with acute generalized exanthematous pustulosis over time: A pharmacovigilance study Open
International audience
View article: Cross‐reactivity among and between macrolides, lincosamides, and streptogramins: Study on the French pharmacovigilance database
Cross‐reactivity among and between macrolides, lincosamides, and streptogramins: Study on the French pharmacovigilance database Open
Background Hypersensitivity reactions (HSR) are reported for the macrolides, lincosamides, and streptogramins (MLS) antibiotic family. Data about cross‐reactivity among and between MLS remain scarce or controversial. Objectives The aim of …
View article: Impact of the vaccination against SARS-CoV-2 campaign on disproportionality indicator from the WHO pharmacovigilance database: A competition bias study from case/non-case analysis
Impact of the vaccination against SARS-CoV-2 campaign on disproportionality indicator from the WHO pharmacovigilance database: A competition bias study from case/non-case analysis Open
We show that a health crisis involving a change in drug use can affect adverse drug reactions reporting and pharmacovigilance databases, leading to competition bias and a change in the disproportionality analyses. For health professionals …
View article: Clinical spectrum and evolution of immune-checkpoint inhibitors toxicities over a decade—a worldwide perspective
Clinical spectrum and evolution of immune-checkpoint inhibitors toxicities over a decade—a worldwide perspective Open
Paul Gougis was supported by the academic program: "Contrats ED: Programme blanc Institut Curie PSL" for the conduct of his PhD. Baptiste Abbar was supported by "the Fondation ARC Pour le Rechercher Sur le Cancer". The RT2L research group …
View article: Management of Adult Patients With Drug Reaction With Eosinophilia and Systemic Symptoms
Management of Adult Patients With Drug Reaction With Eosinophilia and Systemic Symptoms Open
Importance Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction. To our knowledge, there is no international consensus on its severity assessment and treatment. Object…
View article: Data from A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor–Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention
Data from A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor–Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention Open
Immune checkpoint inhibitors (ICI) targeting CTLA4 or PD-1/PD-L1 have transformed cancer therapy but are associated with immune-related adverse events, including myocarditis. Here, we report a robust preclinical mouse model of ICI-associat…
View article: Supplementary Data from A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor–Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention
Supplementary Data from A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor–Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention Open
2 tables and 10 figures
View article: Nirmatrelvir/ritonavir (Paxlovid®): French pharmacovigilance survey 2022
Nirmatrelvir/ritonavir (Paxlovid®): French pharmacovigilance survey 2022 Open
View article: French national diagnosis and care protocol (PNDS, protocole national de diagnostic et de soins): cystic lymphatic malformations
French national diagnosis and care protocol (PNDS, protocole national de diagnostic et de soins): cystic lymphatic malformations Open
View article: Reality of drug-induced erythema multiforme: A French pharmacovigilance study
Reality of drug-induced erythema multiforme: A French pharmacovigilance study Open
Background: Since the 2002 SCAR study, erythema multiforme(EM), a post-infectious disease, has been distinguished from Stevens-Johnson syndrome (SJS), drug-induced. Nevertheless, EM cases are still reported in the French pharmacovigilance …
View article: Incidence and preventability of hospital admissions for adverse drug reactions in France: A prospective observational study (IATROSTAT)
Incidence and preventability of hospital admissions for adverse drug reactions in France: A prospective observational study (IATROSTAT) Open
Aims In the last French study in 2007, the incidence of hospital admissions (HAs) related to adverse drug reactions (ADRs) was 3.6%. The objective was to assess the current ADR‐HA incidence in France and to describe both its characteristic…
View article: Proton Pump Inhibitors Associated With Drug-Induced Lupus Erythematosus
Proton Pump Inhibitors Associated With Drug-Induced Lupus Erythematosus Open
This descriptive case series investigates the potential association between the use of proton pump inhibitors and drug-induced lupus erythematosus in cases reported in 2 large pharmacovigilance databases.
View article: Acute myeloid leukaemia following direct acting antiviral drugs in HCV-infected patients: A 10 years’ retrospective single-center study
Acute myeloid leukaemia following direct acting antiviral drugs in HCV-infected patients: A 10 years’ retrospective single-center study Open
View article: Drug-associated hyperammonaemia: a Bayesian analysis of the WHO Pharmacovigilance Database
Drug-associated hyperammonaemia: a Bayesian analysis of the WHO Pharmacovigilance Database Open
View article: Sweet-like syndrome and multiple COVID arm syndrome following COVID-19 vaccines: ‘specific’ patterns in a series of 192 patients
Sweet-like syndrome and multiple COVID arm syndrome following COVID-19 vaccines: ‘specific’ patterns in a series of 192 patients Open
The two clinico-pathological patterns are ‘Sweet-like syndrome’ and ‘Multiple COVID-Arm’. ‘Sweet-like syndrome’ presents clinically as erythematous and oedematous papules or plaques, sometimes developing vesiculation or bullae. Histology s…
View article: Adverse events associated with JAK inhibitors in 126,815 reports from the WHO pharmacovigilance database
Adverse events associated with JAK inhibitors in 126,815 reports from the WHO pharmacovigilance database Open
View article: Anti-MOG associated disease with intracranial hypertension after COVID-19 vaccination
Anti-MOG associated disease with intracranial hypertension after COVID-19 vaccination Open
View article: Systematic analysis of drug-associated myocarditis reported in the World Health Organization pharmacovigilance database
Systematic analysis of drug-associated myocarditis reported in the World Health Organization pharmacovigilance database Open
While multiple pharmacological drugs have been associated with myocarditis, temporal trends and overall mortality have not been reported. Here we report the spectrum and main features of 5108 reports of drug-induced myocarditis, in a world…
View article: Uveitis Associated with Cancer Immunotherapy: Long-Term Outcomes
Uveitis Associated with Cancer Immunotherapy: Long-Term Outcomes Open
Background: We report the long-term outcome of uveitis associated with cancer immunotherapy (CIT). Methods: This retrospective review included serial patients with CIT-associated uveitis treated using various regimen. Resu…
View article: Adverse events associated with dupilumab in the World Health Organization pharmacovigilance database
Adverse events associated with dupilumab in the World Health Organization pharmacovigilance database Open
View article: COVID-19 vaccine post-marketing surveillance: Cardiovascular doctors have a role to play!
COVID-19 vaccine post-marketing surveillance: Cardiovascular doctors have a role to play! Open
View article: Anticancer drug-induced life-threatening ventricular arrhythmias: a World Health Organization pharmacovigilance study
Anticancer drug-induced life-threatening ventricular arrhythmias: a World Health Organization pharmacovigilance study Open
Aims With the explosion of anticancer drugs, an emerging concern is the risk for drug-induced sudden death (SD) via ventricular arrhythmias (VA). Methods and results We used the international pharmacovigilance database VigiBase (n = 18 441…
View article: Sipuleucel‐T associated inflammatory cardiomyopathy: a case report and observations from a large pharmacovigilance database
Sipuleucel‐T associated inflammatory cardiomyopathy: a case report and observations from a large pharmacovigilance database Open
Aims The major cardiovascular (CV) adverse effects observed with sipuleucel‐T from large multi‐institutional clinical trials included thromboembolic events, myocardial infarction, and congestive heart failure in up to 0.3% of patients with…