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View article: Hippocampal Volumetry: A Promising and Accessible Tool for Early AD Diagnosis in Regions with Limited 18F‐FDG PET Imaging Access?
Hippocampal Volumetry: A Promising and Accessible Tool for Early AD Diagnosis in Regions with Limited 18F‐FDG PET Imaging Access? Open
Background Hippocampal atrophy and hypometabolism are key neuroimaging biomarkers for early diagnosis of Alzheimer's Disease (AD). Artificial intelligence methods for quantitative automated volumetric analysis of brain magnetic resonance i…
View article: Easy-to-use and easy-to-interpret quality control of 3D gradient echo T1-weighted MR acquisition sequences for improved test-retest stability of MRI-based hippocampus volumetry
Easy-to-use and easy-to-interpret quality control of 3D gradient echo T1-weighted MR acquisition sequences for improved test-retest stability of MRI-based hippocampus volumetry Open
Background MRI-based hippocampus volume (HV) is widely used as neurodegeneration marker in Alzheimer's disease. Objective An easy-to-use and easy-to-interpret method to categorize T1-weighted MR sequences with respect to test-retest stabil…
View article: Diffusion Imaging Protocol Heterogeneity Biases Ischemic Core Volume, Location, and Clinical Associations in Acute Stroke
Diffusion Imaging Protocol Heterogeneity Biases Ischemic Core Volume, Location, and Clinical Associations in Acute Stroke Open
BACKGROUND: Diffusion-weighted magnetic resonance imaging is essential for diagnosing ischemic stroke and identifying targets for emergency revascularization. Apparent diffusion coefficient (ADC) maps derived from diffusion-weighted magnet…
View article: Automated Quantitative Susceptibility and Morphometry MR Study: Feasibility and Interrelation Between Clinical Score, Lesion Load, Deep Grey Matter and Normal-Appearing White Matter in Multiple Sclerosis
Automated Quantitative Susceptibility and Morphometry MR Study: Feasibility and Interrelation Between Clinical Score, Lesion Load, Deep Grey Matter and Normal-Appearing White Matter in Multiple Sclerosis Open
Introduction: Lesion load (LL), deep gray matter (DGM) and normal-appearing white matter (NAWM) susceptibility and morphometry may help in monitoring brain changes in multiple sclerosis (MS) patients. We aimed at evaluating the feasibility…
View article: Lipid measures are associated with cognitive functioning in multiple sclerosis patients
Lipid measures are associated with cognitive functioning in multiple sclerosis patients Open
Our results suggest a mild negative impact of dyslipidemia on cognitive performance in patients with MS. We propose that dyslipidemia contributes, at least in part, to cognitive decline in MS patients, independent of brain atrophy.
View article: Fast refacing of <scp>MR</scp> images with a generative neural network lowers re‐identification risk and preserves volumetric consistency
Fast refacing of <span>MR</span> images with a generative neural network lowers re‐identification risk and preserves volumetric consistency Open
With the rise of open data, identifiability of individuals based on 3D renderings obtained from routine structural magnetic resonance imaging (MRI) scans of the head has become a growing privacy concern. To protect subject privacy, several…
View article: Do you see what I see? Diffusion imaging protocol heterogeneity biases ischemic core volume, location, and clinical associations in acute stroke
Do you see what I see? Diffusion imaging protocol heterogeneity biases ischemic core volume, location, and clinical associations in acute stroke Open
Purpose Diffusion-weighted magnetic resonance imaging (DWI) is essential for diagnosing ischemic stroke and identifying targets for emergency revascularization. Apparent diffusion coefficient (ADC) maps derived from DWI are commonly used t…
View article: Neurometabolism and brain morphometry in an adolescent female with an extra‐hepatic congenital portosystemic shunt
Neurometabolism and brain morphometry in an adolescent female with an extra‐hepatic congenital portosystemic shunt Open
Background Chronic hepatic encephalopathy (CHE) has been reported both in patients with congenital porto‐systemic shunts (CPSS) and chronic liver disease. CHE is difficult to recognize in children as there is no clear definition and its ma…
View article: Blood and CSF proteome alterations, and regional brain volumetry patterns associated with neuropsychiatric symptoms in a memory clinic cohort
Blood and CSF proteome alterations, and regional brain volumetry patterns associated with neuropsychiatric symptoms in a memory clinic cohort Open
Background Neuropsychiatric symptoms (NPS) are common in older people, may precede cognitive decline, and are associated with worse long‐term prognosis. However, the underlying pathophysiology remains unclear. Therefore, our main objective…
View article: Interrelation between cardiac and brain small-vessel disease: a pilot quantitative PET and MRI study
Interrelation between cardiac and brain small-vessel disease: a pilot quantitative PET and MRI study Open
Background Small-vessel disease (SVD) plays a crucial role in cardiac and brain ischemia, but little is known about potential interrelation between both. We retrospectively evaluated 370 patients, aiming at assessing the interrelation betw…
View article: Diagnostic delay of multiple sclerosis: prevalence, determinants and consequences
Diagnostic delay of multiple sclerosis: prevalence, determinants and consequences Open
Background: Early diagnosis and treatment of patients with multiple sclerosis (MS) are associated with better outcomes; however, diagnostic delays remain a major problem. Objective: Describe the prevalence, determinants and consequences of…
View article: High field brain proton magnetic resonance spectroscopy and volumetry in children with chronic, compensated liver disease – A pilot study
High field brain proton magnetic resonance spectroscopy and volumetry in children with chronic, compensated liver disease – A pilot study Open
Children with chronic, compensated liver disease did not display an abnormal neurometabolic profile, neurocognitive abnormalities, or signal intensity changes in the globus pallidus. Despite the absence of neurometabolic changes, it is an …
View article: Fast refacing of MR images with a generative neural network lowers re-identification risk and preserves volumetric consistency
Fast refacing of MR images with a generative neural network lowers re-identification risk and preserves volumetric consistency Open
With the rise of open data, identifiability of individuals based on 3D renderings obtained from routine structural magnetic resonance imaging (MRI) scans of the head has become a growing privacy concern. To protect subject privacy, several…
View article: Validity Assessment of an Automated Brain Morphometry Tool for Patients with De Novo Memory Symptoms
Validity Assessment of an Automated Brain Morphometry Tool for Patients with De Novo Memory Symptoms Open
The AI-Rad Companion brain MR imaging tool reliably detects atrophy in cortical and subcortical regions implicated in the differential diagnosis of dementia.
View article: A Multicenter Longitudinal <scp>MRI</scp> Study Assessing <scp>LeMan‐PV</scp> Software Accuracy in the Detection of White Matter Lesions in Multiple Sclerosis Patients
A Multicenter Longitudinal <span>MRI</span> Study Assessing <span>LeMan‐PV</span> Software Accuracy in the Detection of White Matter Lesions in Multiple Sclerosis Patients Open
Background Detecting new and enlarged lesions in multiple sclerosis (MS) patients is needed to determine their disease activity. LeMan‐PV is a software embedded in the scanner reconstruction system of one vendor, which automatically assess…
View article: Personalized maps of T1 relaxometry abnormalities provide correlates of disability in multiple sclerosis patients
Personalized maps of T1 relaxometry abnormalities provide correlates of disability in multiple sclerosis patients Open
We showed that personalized qT1 abnormality maps in MS patients provide measures related to clinical disability, supporting the use of those maps in clinical practice.
View article: Submillimeter <scp>T<sub>1</sub></scp> atlas for subject‐specific abnormality detection at <scp>7T</scp>
Submillimeter <span>T<sub>1</sub></span> atlas for subject‐specific abnormality detection at <span>7T</span> Open
Purpose Studies at 3T have shown that T 1 relaxometry enables characterization of brain tissues at the single‐subject level by comparing individual physical properties to a normative atlas. In this work, an atlas of normative T 1 values at…
View article: Cerebrospinal Fluid Cortisol and Dehydroepiandrosterone Sulfate, Alzheimer’s Disease Pathology, and Cognitive Decline
Cerebrospinal Fluid Cortisol and Dehydroepiandrosterone Sulfate, Alzheimer’s Disease Pathology, and Cognitive Decline Open
Introduction Elevated cortisol levels have been reported in Alzheimer’s disease (AD) and may accelerate the development of brain pathology and cognitive decline. Dehydroepiandrosterone sulfate (DHEAS) has anti-glucocorticoid effects and it…
View article: Systemic and central nervous system neuroinflammatory signatures of neuropsychiatric symptoms and related cognitive decline in older people
Systemic and central nervous system neuroinflammatory signatures of neuropsychiatric symptoms and related cognitive decline in older people Open
Background Neuroinflammation may contribute to psychiatric symptoms in older people, in particular in the context of Alzheimer’s disease (AD). We sought to identify systemic and central nervous system (CNS) inflammatory alterations associa…