Bénédicte Oulès
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View article: Genetic landscape of non‐ <scp>UV</scp> ‐induced cutaneous squamous cell carcinomas
Genetic landscape of non‐ <span>UV</span> ‐induced cutaneous squamous cell carcinomas Open
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and is most often caused by cumulative UV exposure. However, cSCC may also arise independently of UV exposure, on sites of sustained skin damage like chronic ul…
View article: Population Pharmacokinetics of Encorafenib and Binimetinib in Real-World BRAFV600E/K-Mutant Metastatic Melanoma Patients in Comparison with Clinical Results
Population Pharmacokinetics of Encorafenib and Binimetinib in Real-World BRAFV600E/K-Mutant Metastatic Melanoma Patients in Comparison with Clinical Results Open
View article: Cutaneous manifestations associated with substance use disorders
Cutaneous manifestations associated with substance use disorders Open
View article: Impact of gender on self-assessment accuracy among fourth-year French medical students on faculty’s online Objective Structured Clinical Examinations
Impact of gender on self-assessment accuracy among fourth-year French medical students on faculty’s online Objective Structured Clinical Examinations Open
This study reveals similar self-assessment accuracy according to gender in online training OSCEs suggesting a shift towards gender-equitable self-perceptions among medical students compared to previous studies. Research remains necessary t…
View article: Impact of Gender on Self-Assessment Accuracy Among Fourth-Year French Medical Students on Faculty's Objective Structured Clinical Examinations
Impact of Gender on Self-Assessment Accuracy Among Fourth-Year French Medical Students on Faculty's Objective Structured Clinical Examinations Open
Background: Historically, women have been shown to underestimate their abilities, while men often assess themselves more accurately or overestimate. This study aims to determine self-assessment accuracy during Objective Structured Clinical…
View article: Skin hepcidin initiates psoriasiform skin inflammation via Fe-driven hyperproliferation and neutrophil recruitment
Skin hepcidin initiates psoriasiform skin inflammation via Fe-driven hyperproliferation and neutrophil recruitment Open
Psoriasis is a multifactorial, chronic inflammatory skin disease with unresolved questions on its primary events. Iron overload has been described in the epidermis of psoriasis patients, but its relevance remains unknown. We found that the…
View article: Measuring and correcting staff variability in large-scale OSCEs
Measuring and correcting staff variability in large-scale OSCEs Open
Staff variability impacts OSCE scores as much as student variability, and the former can be reduced with dual assessment or adjusted for with mixed models. Both are small compared to unmeasured sources of variability, making them difficult…
View article: Molecularly matched targeted therapy: a promising approach for refractory metastatic melanoma
Molecularly matched targeted therapy: a promising approach for refractory metastatic melanoma Open
Background Only a fraction of patients with metastatic melanoma derive durable benefit from approved treatments. The clinical impact of personalized medicine strategies for melanoma, apart from BRAF, NRAS, or CKIT targeting, has rarely bee…
View article: VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation
VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation Open
View article: Enhanced fetal hematopoiesis in response to symptomatic SARS-CoV-2 infection during pregnancy
Enhanced fetal hematopoiesis in response to symptomatic SARS-CoV-2 infection during pregnancy Open
Background Pregnant women and their fetuses are particularly susceptible to respiratory pathogens. How they respond to SARS-CoV-2 infection is still under investigation. Methods We studied the transcriptome and phenotype of umbilical cord …
View article: Acneiform Eruption Following Elexacaftor-Tezacaftor-Ivacaftor Treatment in Patients With Cystic Fibrosis
Acneiform Eruption Following Elexacaftor-Tezacaftor-Ivacaftor Treatment in Patients With Cystic Fibrosis Open
Importance A new treatment for cystic fibrosis combining 3 CFTR modulators—elexacaftor (ELX), tezacaftor (TEZ), and ivacaftor (IVA)—has recently been approved for cystic fibrosis treatment. The cutaneous adverse effects following treatment…
View article: Contribution of fetal microchimeric cells to maternal wound healing in sickle cell ulcers
Contribution of fetal microchimeric cells to maternal wound healing in sickle cell ulcers Open
Leg ulcers are a major complication of sickle cell disease (SCD). They are particularly challenging to treat and innovative therapies are needed. We previously showed that the healing of SCD ulcers is delayed because of decreased angiogene…
View article: CCL2 recruits fetal microchimeric cells and dampens maternal brain damage in post-partum mice
CCL2 recruits fetal microchimeric cells and dampens maternal brain damage in post-partum mice Open
Preventing brain cell loss and enhancing tissue repair are crucial objectives to improve the outcome of stroke. Fetal microchimerism has been implicated in brain repair following ischemic stroke in mice. CCL2/CCR2 signaling pathway trigger…
View article: Sweet-like syndrome and multiple COVID arm syndrome following COVID-19 vaccines: ‘specific’ patterns in a series of 192 patients
Sweet-like syndrome and multiple COVID arm syndrome following COVID-19 vaccines: ‘specific’ patterns in a series of 192 patients Open
The two clinico-pathological patterns are ‘Sweet-like syndrome’ and ‘Multiple COVID-Arm’. ‘Sweet-like syndrome’ presents clinically as erythematous and oedematous papules or plaques, sometimes developing vesiculation or bullae. Histology s…
View article: Réactions cutanées rares aux vaccins contre la COVID-19 : série de cas monocentrique et revue de la littérature
Réactions cutanées rares aux vaccins contre la COVID-19 : série de cas monocentrique et revue de la littérature Open
View article: Type I Interferon Signature in Chilblains Following SARS-CoV-2 mRNA Vaccine: A Case Report
Type I Interferon Signature in Chilblains Following SARS-CoV-2 mRNA Vaccine: A Case Report Open
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View article: Rare cutaneous adverse effects of COVID‐19 vaccines: a case series and review of the literature
Rare cutaneous adverse effects of COVID‐19 vaccines: a case series and review of the literature Open
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View article: Differential Expression of Insulin-Like Growth Factor 1 and Wnt Family Member 4 Correlates With Functional Heterogeneity of Human Dermal Fibroblasts
Differential Expression of Insulin-Like Growth Factor 1 and Wnt Family Member 4 Correlates With Functional Heterogeneity of Human Dermal Fibroblasts Open
Although human dermis contains distinct fibroblast subpopulations, the functional heterogeneity of fibroblast lines from different donors is under-appreciated. We identified one commercially sourced fibroblast line (c64a) that failed to ex…
View article: Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis
Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis Open
Although acne is the most common human inflammatory skin disease, its pathogenic mechanisms remain incompletely understood. Here we show that GATA6, which is expressed in the upper pilosebaceous unit of normal human skin, is down-regulated…
View article: Cutaneous manifestations in SARS‐CoV‐2 infection (COVID‐19): a French experience and a systematic review of the literature
Cutaneous manifestations in SARS‐CoV‐2 infection (COVID‐19): a French experience and a systematic review of the literature Open
Editor Skin manifestations have been increasingly reported in the setting of COVID-19. However, their incidence and presentation are debated, and the role, direct or indirect, of SARS-CoV-2 in their pathogenesis has yet to be determined. I…
View article: Upregulation of the Sarco-Endoplasmic Reticulum Calcium ATPase 1 Truncated Isoform Plays a Pathogenic Role in Alzheimer’s Disease
Upregulation of the Sarco-Endoplasmic Reticulum Calcium ATPase 1 Truncated Isoform Plays a Pathogenic Role in Alzheimer’s Disease Open
Dysregulation of the Endoplasmic Reticulum (ER) Ca2+ homeostasis and subsequent ER stress activation occur in Alzheimer Disease (AD). We studied the contribution of the human truncated isoform of the sarco-endoplasmic reticulum Ca2+ ATPase…
View article: 660 Dermal fibroblast subpopulations as a potential cell therapy for promoting scar-free wound healing and resolving scar formation
660 Dermal fibroblast subpopulations as a potential cell therapy for promoting scar-free wound healing and resolving scar formation Open
View article: Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors Open
The liver parenchyma is composed of hepatocytes and bile duct epithelial cells (BECs). Controversy exists regarding the cellular origin of human liver parenchymal tissue generation during embryonic development, homeostasis or repair. Here …
View article: Delta-like 1-mediated cis-inhibition of Jagged1/2 signalling inhibits differentiation of human epidermal cells in culture
Delta-like 1-mediated cis-inhibition of Jagged1/2 signalling inhibits differentiation of human epidermal cells in culture Open
View article: Mutant Lef1 controls Gata6 in sebaceous gland development and cancer
Mutant Lef1 controls Gata6 in sebaceous gland development and cancer Open
View article: Single-cell analysis identifies EpCAM<sup>+</sup>/CDH6<sup>+</sup>/TROP-2<sup>−</sup>cells as human liver progenitors
Single-cell analysis identifies EpCAM<sup>+</sup>/CDH6<sup>+</sup>/TROP-2<sup>−</sup>cells as human liver progenitors Open
The liver is largely composed of hepatocytes and bile duct epithelial cells (BECs). Controversy exists as to whether a liver stem/progenitor cell capable of renewing both hepatocytes and BECs exists. Single cell RNA sequencing of freshly i…
View article: Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations
Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Open
Previous studies have shown that mouse dermis is composed of functionally distinct fibroblast lineages. To explore the extent of fibroblast heterogeneity in human skin, we used a combination of comparative spatial transcriptional profiling…
View article: A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis
A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis Open
Epidermal homeostasis depends on a balance between stem cell renewal and terminal differentiation. The transition between the two cell states, termed commitment, is poorly understood. Here, we characterise commitment by integrating transcr…
View article: Author response: A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis
Author response: A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Epidermal homeostasis depends on a balance…
View article: A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis
A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis Open
Epidermal homeostasis depends on a balance between stem cell renewal and terminal differentiation. The transition between the two cell states, termed commitment, is poorly understood. Here we characterise commitment by integrating transcri…