Benedikt Hogan
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View article: Therapeutic Penetrating Keratoplasty for Infectious Corneal Ulcers: Outcomes and Timing
Therapeutic Penetrating Keratoplasty for Infectious Corneal Ulcers: Outcomes and Timing Open
Purpose Therapeutic penetrating keratoplasty (PKP) is often required in severe infectious keratitis unresponsive to medical therapy. This study evaluates visual and surgical outcomes of therapeutic PKP and explores whether surgical timing …
View article: Risk of progression in intermediate age-related macular degeneration among patients using systemic beta-blockers
Risk of progression in intermediate age-related macular degeneration among patients using systemic beta-blockers Open
Purpose This study aims to determine whether systemic beta-blocker use over time influences the progression from intermediate to advanced age-related macular degeneration (AMD). Methods This prospective cohort study utilized data from the …
View article: Fever in focus: Symptoms, diagnoses and treatment of febrile children in Ghana—A longitudinal hospital study
Fever in focus: Symptoms, diagnoses and treatment of febrile children in Ghana—A longitudinal hospital study Open
Background Healthcare resources are often limited in areas of sub‐Saharan Africa. This makes accurate and timely diagnoses challenging and delays treatment of childhood febrile illness. We explored longitudinal characteristics related to s…
View article: Dataset and R script: a longitudinal hospital study of febrile children in Ghana
Dataset and R script: a longitudinal hospital study of febrile children in Ghana Open
This is the dataset and R script accompanying the manuscript "Fever in focus: symptoms, diagnoses, and treatment of febrile children in Ghana, a longitudinal hospital study."
View article: Dataset and R script: a longitudinal hospital study of febrile children in Ghana
Dataset and R script: a longitudinal hospital study of febrile children in Ghana Open
This is the dataset and R script accompanying the manuscript "Fever in focus: symptoms, diagnoses, and treatment of febrile children in Ghana, a longitudinal hospital study."
View article: Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case–control study
Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case–control study Open
View article: Clustering of Cryptosporidium species infections among sheep and cattle but not children in remote highland communities of Madagascar
Clustering of Cryptosporidium species infections among sheep and cattle but not children in remote highland communities of Madagascar Open
View article: Additional file 1 of Clustering of Cryptosporidium species infections among sheep and cattle but not children in remote highland communities of Madagascar
Additional file 1 of Clustering of Cryptosporidium species infections among sheep and cattle but not children in remote highland communities of Madagascar Open
Additional file 1: Table S1. Study data file.
View article: Molecular epidemiology of Respiratory Syncytial Virus in children in sub‐Saharan Africa
Molecular epidemiology of Respiratory Syncytial Virus in children in sub‐Saharan Africa Open
Objectives This study investigated the molecular epidemiology of respiratory syncytial virus (RSV) among febrile children with acute respiratory tract infection in Ghana, Gabon, Tanzania and Burkina Faso between 2014 and 2017 as well as th…
View article: Molecular epidemiology of respiratory syncytial virus in children in sub‐Saharan Africa
Molecular epidemiology of respiratory syncytial virus in children in sub‐Saharan Africa Open
Objectives This study investigated the molecular epidemiology of respiratory syncytial virus (RSV) among febrile children with acute respiratory tract infection in Ghana, Gabon, Tanzania and Burkina Faso between 2014 and 2017 as well as th…
View article: A cross-sectional study on risk factors for infection with Parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana
A cross-sectional study on risk factors for infection with Parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana Open
Parvovirus B19 (B19V) occurs globally and can cause severe anaemia. The role of co-infections with Plasmodium falciparum ( P. falciparum) has been controversially discussed. The study aimed to determine prevalence and severity of B19V infe…
View article: Spectrum of antibiotic resistant bacteria and fungi isolated from chronically infected wounds in a rural district hospital in Ghana
Spectrum of antibiotic resistant bacteria and fungi isolated from chronically infected wounds in a rural district hospital in Ghana Open
The pathogen distribution in chronic wounds in rural Ghana matched the internationally observed patterns with a predominance of P. aeruginosa and S. aureus. Very high resistance rates discourage antibiotic therapy but suggest an urgent nee…
View article: Performance of a rapid diagnostic test for the detection of Cryptosporidium spp. in African children admitted to hospital with diarrhea
Performance of a rapid diagnostic test for the detection of Cryptosporidium spp. in African children admitted to hospital with diarrhea Open
The weak performance of the studied RDT suggests the need to carefully evaluate available commercial RDTs before their use as standard tools in clinical trials and community survey of Cryptosporidium infections in pediatric cohorts.
View article: Spectrum of antibiotic resistant bacteria and fungi isolated from chronically infected wounds in a rural district hospital in Ghana
Spectrum of antibiotic resistant bacteria and fungi isolated from chronically infected wounds in a rural district hospital in Ghana Open
Background: Chronic infected wounds are generally difficult to manage and treatment can be particularly challenging in resource-limited settings where diagnostic testing is not readily available. In this study, the epidemiology of microbia…
View article: Transmission of <i>Cryptosporidium</i> Species Among Human and Animal Local Contact Networks in Sub-Saharan Africa: A Multicountry Study
Transmission of <i>Cryptosporidium</i> Species Among Human and Animal Local Contact Networks in Sub-Saharan Africa: A Multicountry Study Open
Background Cryptosporidiosis has been identified as one of the major causes of diarrhea and diarrhea-associated deaths in young children in sub-Saharan Africa. This study traces back Cryptosporidium-positive children to their human and ani…
View article: Causes of fever in Gabonese children: a cross-sectional hospital-based study
Causes of fever in Gabonese children: a cross-sectional hospital-based study Open
The causes of infections in pediatric populations differ between age groups and settings, particularly in the tropics. Such differences in epidemiology may lead to misdiagnosis and ineffective empirical treatment. Here, we investigated the…
View article: Seroprevalence of Leptospira spp. Infection in Cattle from Central and Northern Madagascar
Seroprevalence of Leptospira spp. Infection in Cattle from Central and Northern Madagascar Open
Leptospirosis is a zoonotic disease of global importance, especially in tropical countries. The current Leptospira spp. seroprevalence in cattle from central and northern Madagascar is unknown. Thus, the aim of this study was to determine …
View article: Viral metagenomics revealed novel betatorquevirus species in pediatric inpatients with encephalitis/meningoencephalitis from Ghana
Viral metagenomics revealed novel betatorquevirus species in pediatric inpatients with encephalitis/meningoencephalitis from Ghana Open
The cause of acute encephalitis/meningoencephalitis in pediatric patients remains often unexplained despite extensive investigations for large panel of pathogens. To explore a possible viral implication, we investigated the virome of cereb…
View article: Detection and Characterization of ESBL-Producing Escherichia coli From Humans and Poultry in Ghana
Detection and Characterization of ESBL-Producing Escherichia coli From Humans and Poultry in Ghana Open
Introduction: The increasing incidence of infections caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in sub-Saharan Africa is of serious concern. Studies from countries with a highly industrialize…
View article: Chlamydiae in febrile children with respiratory tract symptoms and age-matched controls, Ghana
Chlamydiae in febrile children with respiratory tract symptoms and age-matched controls, Ghana Open
View article: Malaria Coinfections in Febrile Pediatric Inpatients: A Hospital-Based Study From Ghana
Malaria Coinfections in Febrile Pediatric Inpatients: A Hospital-Based Study From Ghana Open
In a hospital setting, the likelihood of comorbidity with a nonmalarial disease is inversely correlated with increasing blood levels of malaria parasites. Hence, parasite densities provide important information as an indicator for the prob…
View article: Influence of broth enrichment as well as storage and transport time on the sensitivity of MRSA surveillance in the tropics
Influence of broth enrichment as well as storage and transport time on the sensitivity of MRSA surveillance in the tropics Open
Direct growth on blood and screening agar for methicillin-resistant Staphylococcus aureus (MRSA) at a tropical surveillance site was compared with broth enrichment and subsequent growth on selective MRSA agar after international sample tra…
View article: Burden of influenza among hospitalized febrile children in Ghana
Burden of influenza among hospitalized febrile children in Ghana Open
Background Influenza surveillance data from Africa indicate a substantial disease burden with high mortality. However, local influenza data from district hospitals with limited laboratory facilities are still scarce. Objectives To identify…
View article: Are brucellosis, Q fever and melioidosis potential causes of febrile illness in Madagascar?
Are brucellosis, Q fever and melioidosis potential causes of febrile illness in Madagascar? Open
View article: Nasal Carriage of Staphylococcus aureus among Children in the Ashanti Region of Ghana
Nasal Carriage of Staphylococcus aureus among Children in the Ashanti Region of Ghana Open
S. aureus carriage among Ghanaian children seems to depend on age, sex and seasonality. While MRSA rates are low, the high prevalence of PVL is of serious concern as these strains might serve not only as a source for severe invasive infect…
View article: Prevalence of nasal colonisation by methicillin-sensitive and methicillin-resistant Staphylococcus aureus among healthcare workers and students in Madagascar
Prevalence of nasal colonisation by methicillin-sensitive and methicillin-resistant Staphylococcus aureus among healthcare workers and students in Madagascar Open
View article: Molecular Epidemiology and Antibiotic Susceptibility of Vibrio cholerae Associated with a Large Cholera Outbreak in Ghana in 2014
Molecular Epidemiology and Antibiotic Susceptibility of Vibrio cholerae Associated with a Large Cholera Outbreak in Ghana in 2014 Open
This analysis suggests different endemic reservoirs of V. cholerae in Ghana with distinct annual outbreak clusters accompanied by the occurrence of genetically distant genotypes. Preventive measures for cholera transmission should focus on…
View article: Association Between Malaria and Invasive Nontyphoidal<i>Salmonella</i>Infection in a Hospital Study: Accounting for Berkson's Bias
Association Between Malaria and Invasive Nontyphoidal<i>Salmonella</i>Infection in a Hospital Study: Accounting for Berkson's Bias Open
The study highlights how a selection bias may reverse results if an unsuitable control group is used and adds further evidence on the malaria-iNTS disease association.
View article: Screening agars for MRSA: evaluation of a stepwise diagnostic approach with two different selective agars for the screening for methicillin-resistant Staphylococcus aureus (MRSA)
Screening agars for MRSA: evaluation of a stepwise diagnostic approach with two different selective agars for the screening for methicillin-resistant Staphylococcus aureus (MRSA) Open
The application of the selective agar CHROMagar MRSA alone proved to be too non-specific to allow for a reliable diagnosis of the presence of MRSA. The combined use of two selective agars in a stepwise approach reduced this non-specificity…
View article: Identification of nasal colonization with β-lactamase-producing enterobacteriaceae in patients, health care workers and students in Madagascar
Identification of nasal colonization with β-lactamase-producing enterobacteriaceae in patients, health care workers and students in Madagascar Open
This study assesses the nasal occurrence of β-lactamase-producing Enterobacteriaceae both in patients in a hospital department of infectious diseases at admission and in healthy Madagascan students and health care workers. Nasal swabs from…