Benedikt Junglas
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View article: Membrane binding of a cyanobacterial <scp>ESCRT</scp> ‐ <scp>III</scp> protein crucially involves the helix <i>α</i> 1‐3 hairpin conserved in all superfamily members
Membrane binding of a cyanobacterial <span>ESCRT</span> ‐ <span>III</span> protein crucially involves the helix <i>α</i> 1‐3 hairpin conserved in all superfamily members Open
IM30, the inner membrane‐associated protein of 30 kDa (also known as Vipp1) is essential for thylakoid membrane biogenesis and/or maintenance in chloroplasts and cyanobacteria. IM30 and its bacterial homolog PspA belong to the ESCRT‐III su…
View article: Membrane binding of a cyanobacterial ESCRT-III protein crucially involves the helix α1-3 hairpin conserved in all superfamily members
Membrane binding of a cyanobacterial ESCRT-III protein crucially involves the helix α1-3 hairpin conserved in all superfamily members Open
IM30, the inner membrane-associated protein of 30 kDa (also known as Vipp1) is essential for thylakoid membrane biogenesis and/or maintenance in chloroplasts and cyanobacteria. IM30 and its bacterial homolog PspA belong to the ESCRT-III su…
View article: The bacterial ESCRT-III PspA rods thin lipid tubules and increase membrane curvature through helix α0 interactions
The bacterial ESCRT-III PspA rods thin lipid tubules and increase membrane curvature through helix α0 interactions Open
The phage shock protein A (PspA), a bacterial member of the endosomal sorting complexes required for transport (ESCRT)-III superfamily, forms rod-shaped helical assemblies that internalize membrane tubules. The N-terminal helix α0 of PspA …
View article: The bacterial ESCRT-III PspA rods thin lipid tubules and increase membrane curvature through helix α0 interactions
The bacterial ESCRT-III PspA rods thin lipid tubules and increase membrane curvature through helix α0 interactions Open
The phage shock protein A (PspA), a bacterial member of the ESCRT-III superfamily, forms rod-shaped helical assemblies that internalize membrane tubules. The N-terminal helix α0 of PspA (and other ESCRT-III members) has been suggested to a…
View article: CryoVIA - An image analysis toolkit for the quantification of membrane structures from cryo-EM micrographs
CryoVIA - An image analysis toolkit for the quantification of membrane structures from cryo-EM micrographs Open
Summary Imaging of lipid structures and associated protein complexes using electron cryo-microscopy (cryo-EM) is a common visualization and structure determination technique. The quantitative analysis of the membrane structures, however, i…
View article: Cryo electron micrographs of DOPC vesicles after extrusion with a 50 nm filter
Cryo electron micrographs of DOPC vesicles after extrusion with a 50 nm filter Open
View article: The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic-like membranes
The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic-like membranes Open
View article: Cryo electron micrographs of DOPC vesicles after extrusion with a 200 nm filter
Cryo electron micrographs of DOPC vesicles after extrusion with a 200 nm filter Open
View article: Cryo electron micrographs of DOPC vesicles after sonication
Cryo electron micrographs of DOPC vesicles after sonication Open
View article: Cryo electron micrographs of 70% DOPG 30%DPPG vesicles
Cryo electron micrographs of 70% DOPG 30%DPPG vesicles Open
View article: Structural basis for Vipp1 membrane binding: from loose coats and carpets to ring and rod assemblies
Structural basis for Vipp1 membrane binding: from loose coats and carpets to ring and rod assemblies Open
Vesicle-inducing protein in plastids 1 (Vipp1) is critical for thylakoid membrane biogenesis and maintenance. Although Vipp1 has recently been identified as a member of the endosomal sorting complexes required for transport III superfamily…
View article: Structural basis for GTPase activity and conformational changes of the bacterial dynamin-like protein SynDLP
Structural basis for GTPase activity and conformational changes of the bacterial dynamin-like protein SynDLP Open
SynDLP, a dynamin-like protein (DLP) encoded in the cyanobacterium Synechocystis sp. PCC 6803, has recently been identified to be structurally highly similar to eukaryotic dynamins. To elucidate structural changes during guanosine triphosp…
View article: Structural plasticity of bacterial ESCRT-III protein PspA in higher-order assemblies
Structural plasticity of bacterial ESCRT-III protein PspA in higher-order assemblies Open
View article: SynDLP is a dynamin-like protein of Synechocystis sp. PCC 6803 with eukaryotic features
SynDLP is a dynamin-like protein of Synechocystis sp. PCC 6803 with eukaryotic features Open
View article: Uncommon activation of SynDLP, the fusogenic Dynamin-like protein of the cyanobacterium Synechocystis sp. PCC 6803
Uncommon activation of SynDLP, the fusogenic Dynamin-like protein of the cyanobacterium Synechocystis sp. PCC 6803 Open
Dynamin-like proteins are membrane remodeling GTPases with well-understood functions in eukaryotic cells. However, bacterial Dynamin-like proteins are still poorly investigated. SynDLP, the Dynamin-like protein of the cyanobacterium Synech…
View article: The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic membranes, shedding light on the emergence of eukaryogenesis
The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic membranes, shedding light on the emergence of eukaryogenesis Open
The ESCRT machinery mediates membrane remodeling in numerous processes in cells including cell division and nuclear membrane reformation. The identification of ESCRT homologs in Asgard archaea, currently considered the closest ancestor of …
View article: Membrane destabilization and pore formation induced by the Synechocystis IM30 protein
Membrane destabilization and pore formation induced by the Synechocystis IM30 protein Open
View article: Human Claudin-7 cis-Interactions Are Not Crucial for Membrane-Membrane (Trans-) Interactions
Human Claudin-7 cis-Interactions Are Not Crucial for Membrane-Membrane (Trans-) Interactions Open
Human Claudin-7 (Cldn7) is a member of the Claudin (Cldn) superfamily. In vivo , these proteins form tight junctions, which establish constricted connections between cells. Cldns oligomerize within the membrane plane (= cis -interaction), …
View article: Binding and/or hydrolysis of purine‐based nucleotides is not required for IM30 ring formation
Binding and/or hydrolysis of purine‐based nucleotides is not required for IM30 ring formation Open
IM30, the inner membrane‐associated protein of 30 kDa, is conserved in cyanobacteria and chloroplasts. Although its exact physiological function is still mysterious, IM30 is clearly essential for thylakoid membrane biogenesis and/or dynami…
View article: IM30 IDPs form a membrane-protective carpet upon super-complex disassembly
IM30 IDPs form a membrane-protective carpet upon super-complex disassembly Open
Members of the phage shock protein A (PspA) family, including the inner membrane-associated protein of 30 kDa (IM30), are suggested to stabilize stressed cellular membranes. Furthermore, IM30 is essential in thylakoid membrane-containing c…
View article: Mg<sup>2+</sup>-binding shifts the IM30 activity from membrane protection to membrane destabilization
Mg<sup>2+</sup>-binding shifts the IM30 activity from membrane protection to membrane destabilization Open
The inner membrane-associated protein of 30 kDa (IM30) is essential in chloroplasts and cyanobacteria. The spatio-temporal cellular localization of the protein appears to be highly dynamic and triggered by internal as well as external stim…
View article: PspA adopts an ESCRT-III-like fold and remodels bacterial membranes
PspA adopts an ESCRT-III-like fold and remodels bacterial membranes Open
Summary PspA is the main effector of the phage shock protein (Psp) system and preserves the bacterial inner membrane integrity and function. Here, we present the 3.6 Å resolution cryo-EM structure of PspA assembled in helical rods. PspA mo…
View article: IM30 IDPs form a membrane protective carpet upon super-complex disassembly
IM30 IDPs form a membrane protective carpet upon super-complex disassembly Open
Members of the phage shock protein A (PspA) family, including the inner membrane-associated protein of 30 kDa (IM30), are suggested to stabilize stressed cellular membranes. Furthermore, IM30 is essential in thylakoid membrane-containing c…
View article: Proton Leakage Is Sensed by IM30 and Activates IM30-Triggered Membrane Fusion
Proton Leakage Is Sensed by IM30 and Activates IM30-Triggered Membrane Fusion Open
The inner membrane-associated protein of 30 kDa (IM30) is crucial for the development and maintenance of the thylakoid membrane system in chloroplasts and cyanobacteria. While its exact physiological function still is under debate, it has …
View article: GTP hydrolysis by Synechocystis IM30 does not decisively affect its membrane remodeling activity
GTP hydrolysis by Synechocystis IM30 does not decisively affect its membrane remodeling activity Open
View article: Functional Implications of Multiple IM30 Oligomeric States
Functional Implications of Multiple IM30 Oligomeric States Open
The inner membrane-associated protein of 30 kDa (IM30), also known as the vesicle-inducing protein in plastids 1 (Vipp1), is essential for photo-autotrophic growth of cyanobacteria, algae and higher plants. While its exact function still r…
View article: Mg2+ binding triggers rearrangement of the IM30 ring structure, resulting in augmented exposure of hydrophobic surfaces competent for membrane binding
Mg2+ binding triggers rearrangement of the IM30 ring structure, resulting in augmented exposure of hydrophobic surfaces competent for membrane binding Open
View article: What is Vipp1 good for?
What is Vipp1 good for? Open
Summary While Vipp1 (also known as IM30) clearly is essential for proper biogenesis of thylakoid membranes in chloroplasts and cyanobacteria, the exact function of Vipp1/IM30 still remains unclear. The recent in vivo study of Gutu et al . …