Benjamin Krämer
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View article: IL-17A-producing NKp44(−) group 3 innate lymphoid cells accumulate in Familial Adenomatous Polyposis duodenal tissue
IL-17A-producing NKp44(−) group 3 innate lymphoid cells accumulate in Familial Adenomatous Polyposis duodenal tissue Open
View article: Abnormal activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron contributes to fructose-induced salt-sensitive hypertension
Abnormal activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron contributes to fructose-induced salt-sensitive hypertension Open
Fructose high-salt (FHS) diets increase blood pressure (BP) in an angiotensin II (Ang II)-dependent manner. Ang II stimulates aldosterone release, which, by acting on the mineralocorticoid receptor (MR), regulates Na + reabsorption by the …
View article: Profiling Cell Heterogeneity and Fructose Transporter Expression in the Rat Nephron by Integrating Single-Cell and Microdissected Tubule Segment Transcriptomes
Profiling Cell Heterogeneity and Fructose Transporter Expression in the Rat Nephron by Integrating Single-Cell and Microdissected Tubule Segment Transcriptomes Open
Single-cell RNA sequencing (scRNAseq) is a crucial tool in kidney research. These technologies cluster cells based on transcriptome similarity, irrespective of the anatomical location and order within the nephron. Thus, a transcriptome clu…
View article: Genetic Variation in Angiotensin II Type 1 Receptor Is Linked to Lipid Levels and Hepatic Steatosis in Alcohol-Associated Liver Disease, but Not to Cirrhosis or Hepatocellular Carcinoma
Genetic Variation in Angiotensin II Type 1 Receptor Is Linked to Lipid Levels and Hepatic Steatosis in Alcohol-Associated Liver Disease, but Not to Cirrhosis or Hepatocellular Carcinoma Open
Background: Development of cirrhosis and hepatocellular carcinoma (HCC) in patients with high alcohol intake is modulated by genetic predispositions. Genetic variation in angiotensin II type 1 receptor (AGTR1) has been described as a risk …
View article: Profiling cellular heterogeneity and fructose transporter expression in the rat nephron by integrating single-cell and microdissected tubule segment transcriptomes
Profiling cellular heterogeneity and fructose transporter expression in the rat nephron by integrating single-cell and microdissected tubule segment transcriptomes Open
Single-cell RNA sequencing (scRNAseq) is a crucial tool in kidney research. These technologies cluster cells according to transcriptome similarity, irrespective of the anatomical location and ordering within the nephron. Thus, a cluster tr…
View article: Branched stented anastomosis frozen elephant trunk repair: Early results from a physician-sponsored investigational device exemption study
Branched stented anastomosis frozen elephant trunk repair: Early results from a physician-sponsored investigational device exemption study Open
View article: IL-6–Dependent STAT3 Activation and Induction of Proinflammatory Cytokines in Primary Sclerosing Cholangitis
IL-6–Dependent STAT3 Activation and Induction of Proinflammatory Cytokines in Primary Sclerosing Cholangitis Open
INTRODUCTION: Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease with periductal inflammation and fibrosis. Genetic studies suggest inflammatory cytokines and IL-6–dependent activation of transcription factor STAT3 as…
View article: High producer variant of lipoprotein lipase may protect from hepatocellular carcinoma in alcohol-associated cirrhosis
High producer variant of lipoprotein lipase may protect from hepatocellular carcinoma in alcohol-associated cirrhosis Open
Hepatocellular carcinoma is a severe complication of liver cirrhosis influenced by genetic predisposition. We found that a genetic variant in the gene encoding lipoprotein lipase reduces the risk for hepatocellular carcinoma in alcohol-ass…
View article: Single-cell RNA sequencing identifies a population of human liver-type ILC1s
Single-cell RNA sequencing identifies a population of human liver-type ILC1s Open
View article: Genetic Variation of SAMM50 Is Not an Independent Risk Factor for Alcoholic Hepatocellular Carcinoma in Caucasian Patients
Genetic Variation of SAMM50 Is Not an Independent Risk Factor for Alcoholic Hepatocellular Carcinoma in Caucasian Patients Open
Hepatocellular carcinoma (HCC) is a severe complication of advanced alcoholic liver disease, which is modulated by genetic predisposition. Identifying new genetic loci might improve screening. Genetic variation of SAMM50 was linked to HCC.…
View article: „Wenn der Steuermann ruft…“ (Epiktet, <i>Encheiridion</i> 7)
„Wenn der Steuermann ruft…“ (Epiktet, <i>Encheiridion</i> 7) Open
Epictetus’/Arrianus’ Encheiridion is for the most part a lucid and readily understandable text. The precise meaning of c. 7 and its imagery, however, is still a matter of dispute. The present paper offers a reinterpretation of c. 7 which t…
View article: Mitochondrial Dysfunction Contributes to Impaired Cytokine Production of CD56bright Natural Killer Cells From Human Immunodeficiency Virus–Infected Individuals Under Effective Antiretroviral Therapy
Mitochondrial Dysfunction Contributes to Impaired Cytokine Production of CD56bright Natural Killer Cells From Human Immunodeficiency Virus–Infected Individuals Under Effective Antiretroviral Therapy Open
Human immunodeficiency virus (HIV) infection is associated with impaired natural killer (NK) cell activity, which is only incompletely restored under antiretroviral therapy. Analyzing the bioenergetics profiles of oxygen consumption, we ob…
View article: Vascular hyperacetylation is associated with vascular smooth muscle dysfunction in a rat model of non-obese type 2 diabetes
Vascular hyperacetylation is associated with vascular smooth muscle dysfunction in a rat model of non-obese type 2 diabetes Open
View article: Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination
Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination Open
We compared the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in patients with natural infection and…
View article: Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19 Open
View article: A genetic variant in toll‐like receptor 5 is linked to chemokine levels and hepatocellular carcinoma in steatohepatitis
A genetic variant in toll‐like receptor 5 is linked to chemokine levels and hepatocellular carcinoma in steatohepatitis Open
Background & Aims Bacterial translocation drives liver disease progression. We investigated whether functional genetic variants in toll‐like receptor 5 (TLR5) , the receptor for bacterial flagellin, affect the risk for hepatocellular carci…
View article: Swarm Learning for decentralized and confidential clinical machine learning
Swarm Learning for decentralized and confidential clinical machine learning Open
View article: Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
View article: Additional file 1 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 1 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 1: Table S1. Cohort statistics.
View article: Additional file 3 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 3 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 3: Table S2. Differential genes.
View article: Additional file 8 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 8 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 8: Table S7. Drugs overview.
View article: Additional file 4 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 4 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 4: Table S3. CoCena modules.
View article: Additional file 9 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 9 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 9: Table S8. Differential genes of groups G1-G6.
View article: Additional file 10 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 10 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 10: Table S9. Predicted drugs.
View article: Additional file 5 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 5 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 5: Table S4. Granulocytes anno, differential genes and neutrophil subtypes.
View article: Additional file 6 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 6 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 6: Table S5. Overview of datasets.
View article: Additional file 7 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 7 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 7: Table S6. Immune cell type signatures.
View article: Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia
Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia Open
In hospitalized patients with Covid-19 pneumonia who were not receiving mechanical ventilation, tocilizumab reduced the likelihood of progression to the composite outcome of mechanical ventilation or death, but it did not improve survival.…
View article: TLR agonists enhance responsiveness of inflammatory innate immune cells in HLA-B*57-positive HIV patients
TLR agonists enhance responsiveness of inflammatory innate immune cells in HLA-B*57-positive HIV patients Open
View article: Drosophila MUS312 Interacts with the Nucleotide Excision Repair Endonuclease MEI-9 to Generate Meiotic Crossovers
Drosophila MUS312 Interacts with the Nucleotide Excision Repair Endonuclease MEI-9 to Generate Meiotic Crossovers Open
MEI-9 is the Drosophila homolog of the human structure-specific DNA endonuclease XPF. Like XPF, MEI-9 functions in nucleotide excision repair and interstrand crosslink repair. MEI-9 is also required to generate meiotic crossovers, in a fun…