Benedikt M. Schaarschmidt
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View article: High incidence and poor prognosis of bone metastases in functioning small intestinal neuroendocrine tumors
High incidence and poor prognosis of bone metastases in functioning small intestinal neuroendocrine tumors Open
Background The prevalence and clinical relevance of bone metastases (BM) in advanced small intestinal neuroendocrine tumors (siNETs) is not well-documented. Methods We analyzed data from 458 patients (54% male, median age 58 years) with hi…
View article: Leveraging Sarcopenia index by automated CT body composition analysis for pan cancer prognostic stratification
Leveraging Sarcopenia index by automated CT body composition analysis for pan cancer prognostic stratification Open
View article: Hemoptysis in a patient with MDR-tuberculosis: successful diagnosis with photon counting CT and embolization of a Rasmussen aneurysm
Hemoptysis in a patient with MDR-tuberculosis: successful diagnosis with photon counting CT and embolization of a Rasmussen aneurysm Open
Background Multidrug-resistant tuberculosis (MDR-TB) remains a significant clinical challenge and may be complicated by life-threatening hemoptysis. One rare but serious cause of hemoptysis in TB patients is the development of pulmonary ar…
View article: Radiation exposure of chest and abdomen computed tomography in pediatric trauma patients
Radiation exposure of chest and abdomen computed tomography in pediatric trauma patients Open
Background:
Combined chest and abdomen CT in pediatric trauma patients is rare and typically reserved for severely injured patients due to concerns about the potential radiation risks associated with CT in children. This study aims to …
View article: Evaluation of diffusion-weighted imaging datasets for the assessment of disease activity in lymphoma patients
Evaluation of diffusion-weighted imaging datasets for the assessment of disease activity in lymphoma patients Open
The present study demonstrates a strong association between metabolic activity and the cellularity of lymphomas. Furthermore, our results reveal a good performance of DWI-derived ADC values for the differentiation between vital and avital …
View article: Does volume change of the spleen correlate with the therapy response in uveal melanoma patients with liver metastases undergoing hepatic artery infusion chemotherapy?
Does volume change of the spleen correlate with the therapy response in uveal melanoma patients with liver metastases undergoing hepatic artery infusion chemotherapy? Open
Background Uveal melanoma (UM) patients with liver metastases often undergo hepatic artery infusion therapy (HAIC). Due to diffuse metastatic spread in the liver, patients often develop hepatomegaly and secondary, portal hypertension which…
View article: Video-assisted informed consent in cardiac imaging: influence on patient experience during CT—the randomized controlled VAICICI Trial
Video-assisted informed consent in cardiac imaging: influence on patient experience during CT—the randomized controlled VAICICI Trial Open
Objective Patient compliance and comfort during cardiac computed tomography (CT) are crucial for optimal imaging outcomes. Insufficient understanding or heightened anxiety can negatively impact patient experience and potentially image qual…
View article: The effect of durvalumab consolidation after definitive radiochemotherapy for non-operable stage III non-small cell lung cancer on the dose effect relation for therapy related pulmonary infiltrates as a risk factor for pneumonitis
The effect of durvalumab consolidation after definitive radiochemotherapy for non-operable stage III non-small cell lung cancer on the dose effect relation for therapy related pulmonary infiltrates as a risk factor for pneumonitis Open
The relationship between radiation dose and lung infiltrates observed by follow-up CT scans after radiochemotherapy is sensitive enough to detect factors that systematically increase the radiation dose response. In this case, the focus is …
View article: Degradable Starch Microsphere Transarterial Chemoembolization as Salvage Therapy in Patients with Uveal Melanoma Liver Metastases
Degradable Starch Microsphere Transarterial Chemoembolization as Salvage Therapy in Patients with Uveal Melanoma Liver Metastases Open
DSM-TACE represents a salvage treatment option for patients with UM with liver metastases that can help control the tumor. Lower pretreatment serum LDH levels and low TGR have been associated with prolonged mOS. However, direct comparison …
View article: Current Use, Effectiveness, and Safety of Image-Guided Bone Biopsies: Insights from the Registry of the German Society for Interventional Radiology and Minimally Invasive Therapy (DeGIR) Data 2018–2022
Current Use, Effectiveness, and Safety of Image-Guided Bone Biopsies: Insights from the Registry of the German Society for Interventional Radiology and Minimally Invasive Therapy (DeGIR) Data 2018–2022 Open
Image-guided bone biopsies have become indispensable in the diagnosis of a wide range of diseases, from incidental suspicious lesions to the evaluation of treatment response and the staging of malignancies. The aim of this evaluation of th…
View article: Photon-counting CT for bullet material differentiation: applications in forensic radiology
Photon-counting CT for bullet material differentiation: applications in forensic radiology Open
View article: Adverse effects of systemic advanced melanoma therapies—do BRAF/MEK inhibitors increase the incidence of mesenteric panniculitis?
Adverse effects of systemic advanced melanoma therapies—do BRAF/MEK inhibitors increase the incidence of mesenteric panniculitis? Open
Objectives BRAF/MEK inhibitors (BRAFi/MEKi) and PD-1 and CTLA-4 immune checkpoint inhibitors (ICI) have revolutionized malignant melanoma treatment and improved patients’ clinical outcome significantly. However, these therapies are associa…
View article: Conference on challenges in sarcoma (CCS) 2024: Expert opinions on non-evidence-based management aspects
Conference on challenges in sarcoma (CCS) 2024: Expert opinions on non-evidence-based management aspects Open
CCS2024 provides a framework for clinical decision making and underscores the importance of consensus-driven approaches in the treatment of rare and complex malignancies.
View article: Current use of percutaneous ablation in renal tumors: an analysis of the registry of the German Society for Interventional Radiology and Minimally Invasive Therapy
Current use of percutaneous ablation in renal tumors: an analysis of the registry of the German Society for Interventional Radiology and Minimally Invasive Therapy Open
Objective To evaluate the success and complications of thermal ablation (TA) based on the voluntary, prospective registry of the German Society for Interventional Radiology and Minimally Invasive Therapy (DeGIR) with 303 participating cent…
View article: Evaluation of Inflammatory Markers as Prognostic Factors in the Treatment of Hepatocellular Carcinoma (HCC) with Degradable Starch Microspheres by Transarterial Chemoembolization (DSM-TACE)
Evaluation of Inflammatory Markers as Prognostic Factors in the Treatment of Hepatocellular Carcinoma (HCC) with Degradable Starch Microspheres by Transarterial Chemoembolization (DSM-TACE) Open
Objective: To evaluate the prognostic value of pre-therapeutic inflammatory markers before transarterial chemoembolization with degradable starch microspheres (DSM-TACE) in the treatment of hepatocellular carcinoma (HCC). Methods: A total …
View article: Assessment of the physiological effects and safety of transpulmonary chemoembolization with doxorubicin on pulmonary tissue using a human-isolated lung perfusion model
Assessment of the physiological effects and safety of transpulmonary chemoembolization with doxorubicin on pulmonary tissue using a human-isolated lung perfusion model Open
Background Whole lung transpulmonary chemoembolization using a combination of doxorubicin (DXO) and degradable starch microspheres (DSM-TPCE) might be a promising treatment option in soft tissue sarcoma. To pave the way for clinical studie…
View article: Albumin-muscle density score predicts overall survival in patients with hepatocellular cancer undergoing treatment with transarterial chemoembolization
Albumin-muscle density score predicts overall survival in patients with hepatocellular cancer undergoing treatment with transarterial chemoembolization Open
Purpose The purpose of the present study was to analyze associations between different skeletal muscle quality parameters and survival in patients with hepatocellular carcinoma (HCC) undergoing treatment with transarterial chemoembolizatio…
View article: Liver volumetry improves evaluation of treatment response to hepatic artery infusion chemotherapy in uveal melanoma patients with liver metastases
Liver volumetry improves evaluation of treatment response to hepatic artery infusion chemotherapy in uveal melanoma patients with liver metastases Open
Background In uveal melanoma patients, short-term evaluation of treatment response to hepatic artery infusion chemotherapy (HAIC) using the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria is challenging due to the diffus…
View article: Albumin-muscle density score predicts overall survival in patients with hepatocellular cancer undergoing treatment with transarterial chemoembolization
Albumin-muscle density score predicts overall survival in patients with hepatocellular cancer undergoing treatment with transarterial chemoembolization Open
Purpose The purpose of the present study was to analyze associations between different skeletal muscle quality parameters and survival in patients with hepatocellular carcinoma (HCC) undergoing treatment with transarterial chemoembolizatio…
View article: Trans-arterial embolization for treatment of acute lower gastrointestinal bleeding—a multicenter analysis
Trans-arterial embolization for treatment of acute lower gastrointestinal bleeding—a multicenter analysis Open
View article: CT-based body composition analysis and pulmonary fat attenuation volume as biomarkers to predict overall survival in patients with non-specific interstitial pneumonia
CT-based body composition analysis and pulmonary fat attenuation volume as biomarkers to predict overall survival in patients with non-specific interstitial pneumonia Open
Background Non-specific interstitial pneumonia (NSIP) is an interstitial lung disease that can result in end-stage fibrosis. We investigated the influence of body composition and pulmonary fat attenuation volume (CTpfav) on overall surviva…
View article: Opportunistic Screening for Low Bone Mineral Density in Adults with Cystic Fibrosis Using Low-Dose Computed Tomography of the Chest with Artificial Intelligence
Opportunistic Screening for Low Bone Mineral Density in Adults with Cystic Fibrosis Using Low-Dose Computed Tomography of the Chest with Artificial Intelligence Open
Background: Cystic fibrosis bone disease (CFBD) is a common comorbidity in adult people with cystic fibrosis (pwCF), resulting in an increased risk of bone fractures. This study evaluated the capacity of artificial intelligence (AI)-assist…
View article: Low-dose high-resolution chest CT in adults with cystic fibrosis: intraindividual comparison between photon-counting and energy-integrating detector CT
Low-dose high-resolution chest CT in adults with cystic fibrosis: intraindividual comparison between photon-counting and energy-integrating detector CT Open
Background Regular disease monitoring with low-dose high-resolution (LD-HR) computed tomography (CT) scans is necessary for the clinical management of people with cystic fibrosis (pwCF). The aim of this study was to compare the image quali…
View article: Automated 3D-Body Composition Analysis as a Predictor of Survival in Patients With Idiopathic Pulmonary Fibrosis
Automated 3D-Body Composition Analysis as a Predictor of Survival in Patients With Idiopathic Pulmonary Fibrosis Open
Purpose: Idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease, with a median survival time of 2 to 5 years. The focus of this study is to establish a novel imaging biomarker. Materials and Methods: In this study…
View article: SALT: Introducing a Framework for Hierarchical Segmentations in Medical Imaging using Softmax for Arbitrary Label Trees
SALT: Introducing a Framework for Hierarchical Segmentations in Medical Imaging using Softmax for Arbitrary Label Trees Open
Traditional segmentation networks approach anatomical structures as standalone elements, overlooking the intrinsic hierarchical connections among them. This study introduces Softmax for Arbitrary Label Trees (SALT), a novel approach design…
View article: AI-derived body composition parameters as prognostic factors in patients with HCC undergoing TACE in a multicenter study
AI-derived body composition parameters as prognostic factors in patients with HCC undergoing TACE in a multicenter study Open
View article: Elexacaftor/tezacaftor/ivacaftor influences body composition in adults with cystic fibrosis: a fully automated CT-based analysis
Elexacaftor/tezacaftor/ivacaftor influences body composition in adults with cystic fibrosis: a fully automated CT-based analysis Open
A poor nutritional status is associated with worse pulmonary function and survival in people with cystic fibrosis (pwCF). CF transmembrane conductance regulator modulators can improve pulmonary function and body weight, but more data is ne…
View article: Body composition impacts outcome of bronchoscopic lung volume reduction in patients with severe emphysema: a fully automated CT-based analysis
Body composition impacts outcome of bronchoscopic lung volume reduction in patients with severe emphysema: a fully automated CT-based analysis Open
View article: AI-Assisted X-ray Fracture Detection in Residency Training: Evaluation in Pediatric and Adult Trauma Patients
AI-Assisted X-ray Fracture Detection in Residency Training: Evaluation in Pediatric and Adult Trauma Patients Open
Background: This study aimed to evaluate the impact of an AI-assisted fracture detection program on radiology residents’ performance in pediatric and adult trauma patients and assess its implications for residency training. Methods: This s…
View article: The importance of educational tools and a new software solution for visualizing and quantifying report correction in radiology training
The importance of educational tools and a new software solution for visualizing and quantifying report correction in radiology training Open
A novel software, DiffTool, was developed in-house to keep track of changes made by board-certified radiologists to preliminary reports created by residents and evaluate its impact on radiological hands-on training. Before (t 0 ) and after…