Beng Yang
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View article: GPC3-based circular RNA vaccine suppresses hepatocellular carcinoma progression by activating adaptive immune responses
GPC3-based circular RNA vaccine suppresses hepatocellular carcinoma progression by activating adaptive immune responses Open
Background and Aims: Messenger RNA (mRNA) vaccine is a promising approach for cancer therapy. However, the development of mRNA cancer vaccines encounters several challenges, including mRNA instability, inefficient delivery systems, and pot…
View article: Comparative Outcomes of Split versus Whole Liver Transplantation in Adult ESLD Recipients: A Multicenter Propensity-Matched Analysis
Comparative Outcomes of Split versus Whole Liver Transplantation in Adult ESLD Recipients: A Multicenter Propensity-Matched Analysis Open
This multicenter study (2018–2022) compared split liver (SLT) vs. whole liver (WLT) transplantation in 5,978 adults (1,532 SLT; 4,446 WLT). Propensity-matched analysis showed HCC-SLT recipients had higher early allograft dysfunction (25.7%…
View article: The effect of TIM1+ Breg cells in liver ischemia-reperfusion injury
The effect of TIM1+ Breg cells in liver ischemia-reperfusion injury Open
Liver transplantation is the only effective method for end-stage liver disease; however, liver ischemia reperfusion injury (IRI) seriously affects donor liver function after liver transplantation. IRI is a pathophysiological process in whi…
View article: MYBBP1A‑mediated IGFBP4 promoter methylation promotes epithelial‑mesenchymal transition and metastasis through activation of NOTCH pathway in liver cancer
MYBBP1A‑mediated IGFBP4 promoter methylation promotes epithelial‑mesenchymal transition and metastasis through activation of NOTCH pathway in liver cancer Open
Metastatic hepatocellular carcinoma (HCC) seriously threatens patients' prognosis. It was previously suggested that the insulin growth factor binding protein (IGFBP) family could serve as cancer suppressors in the development and metastasi…
View article: Integrated Multiomics Reveals Silencing of has_circ_0006646 Promotes TRIM21‐Mediated NCL Ubiquitination to Inhibit Hepatocellular Carcinoma Metastasis
Integrated Multiomics Reveals Silencing of has_circ_0006646 Promotes TRIM21‐Mediated NCL Ubiquitination to Inhibit Hepatocellular Carcinoma Metastasis Open
Recent studies suggest that circular RNA (circRNA)‐mediated post‐translational modification of RNA‐binding proteins (RBP) plays a pivotal role in metastasis of hepatocellular carcinoma (HCC). However, the specific mechanism and potential c…
View article: Mitochondrial TSPO Promotes Hepatocellular Carcinoma Progression through Ferroptosis Inhibition and Immune Evasion
Mitochondrial TSPO Promotes Hepatocellular Carcinoma Progression through Ferroptosis Inhibition and Immune Evasion Open
Hepatocellular carcinoma (HCC) is one of the most common malignancies with poor prognosis, and novel treatment strategies are urgently needed. Mitochondria are key regulators of cellular homeostasis and potential targets for tumor therapy.…
View article: <p><em>MST4</em> Regulates Epithelial–Mesenchymal Transition of Choriocarcinoma by Mediating TGF-β1 Expression</p>
<em>MST4</em> Regulates Epithelial–Mesenchymal Transition of Choriocarcinoma by Mediating TGF-β1 Expression Open
Our studies demonstrated that MST4 was lowly expressed in patient samples. Additionally, JAR and JEG-3 increase cell invasion and migration ability while there is no influence on cell proliferation with MST4 knockdown. Conversely, the meta…
View article: High-metastatic cancer cells derived exosomal miR92a-3p promotes epithelial-mesenchymal transition and metastasis of low-metastatic cancer cells by regulating PTEN/Akt pathway in hepatocellular carcinoma
High-metastatic cancer cells derived exosomal miR92a-3p promotes epithelial-mesenchymal transition and metastasis of low-metastatic cancer cells by regulating PTEN/Akt pathway in hepatocellular carcinoma Open
Exosomes play an important role in intercellular communication and metastatic progression of hepatocellular carcinoma (HCC). However, cellular communication between heterogeneous HCC cells with different metastatic potentials and the resul…
View article: ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1
ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1 Open
Background N6-methyladenosine (m 6 A) modification is an emerging layer of epigenetic regulation which is widely implicated in the tumorigenicity of hepatocellular carcinoma (HCC), offering a novel perspective for investigating molecular p…
View article: Additional file 2 of ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1
Additional file 2 of ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1 Open
Additional file 2 : Table S2. Target sequences of siRNAs and shRNAs utilized in this work.
View article: Additional file 4 of ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1
Additional file 4 of ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1 Open
Additional file 4 : Table S4. Antibodies utilized in this work.
View article: Additional file 3 of ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1
Additional file 3 of ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1 Open
Additional file 3 : Table S3. Sequences of primers utilized in this study.
View article: A novel mRNA-miRNA-lncRNA competing endogenous RNA triple sub-network associated with prognosis of pancreatic cancer
A novel mRNA-miRNA-lncRNA competing endogenous RNA triple sub-network associated with prognosis of pancreatic cancer Open
In a word, we established a novel mRNA-miRNA-lncRNA sub-network, among which each RNA may be utilized as a prognostic biomarker of pancreatic cancer.
View article: Additional file 2: of WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1
Additional file 2: of WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1 Open
Table S2. Antibodies used in this work. (XLSX 9 kb)
View article: Additional file 1: of WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1
Additional file 1: of WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1 Open
Table S1. Sequences of primers used in this study. (XLSX 9 kb)
View article: Additional file 3: of WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1
Additional file 3: of WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1 Open
Table S3. Target sequences of siRNAs or shRNAs used in this work. (XLSX 8 kb)
View article: miR-424-5p represses the metastasis and invasion of intrahepatic cholangiocarcinoma by targeting ARK5
miR-424-5p represses the metastasis and invasion of intrahepatic cholangiocarcinoma by targeting ARK5 Open
MicroRNAs (miRNAs) have been validated to play prominent roles in the occurrence and development of many kinds of malignant cancer. MiR-424-5p has been reported to participate in various tumors proliferation and metastasis as a suppressor.…
View article: Additional file 4: of WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1
Additional file 4: of WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1 Open
Table S4. RNA-seq results in this work. (XLSX 3149 kb)
View article: Dimethyl fumarate suppresses hepatocellular carcinoma progression via activating SOCS3/JAK1/STAT3 signaling pathway.
Dimethyl fumarate suppresses hepatocellular carcinoma progression via activating SOCS3/JAK1/STAT3 signaling pathway. Open
Dimethyl fumarate (DMF) is generally used to treat psoriasis and multiple sclerosis. In the present study, we aimed to investigate the effects of DMF on hepatocellular carcinoma progression and its mechanism of action. In vitro, cell viabi…
View article: H2A.Z regulates tumorigenesis, metastasis and sensitivity to cisplatin in intrahepatic cholangiocarcinoma
H2A.Z regulates tumorigenesis, metastasis and sensitivity to cisplatin in intrahepatic cholangiocarcinoma Open
Intrahepatic cholangiocarcinoma (ICC) is a fatal, malignant tumor of the liver; effective diagnostic biomarkers and therapeutic targets for ICC have not been identified yet. High expression of H2A histone family member Z (H2A.Z) is a high-…
View article: Autophagy blockade enhances the anti-cancer effect of Romidepsin in gastric cancer
Autophagy blockade enhances the anti-cancer effect of Romidepsin in gastric cancer Open
Background: Autophagy, also known as macroautophagy, is a catabolic process that occurs in response to stress conditions to maintain cellular homeostasis. Inhibiting autophagy has been proposed as a new therapeutic strategy that could enha…
View article: KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling
KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling Open
A lack of effective prognostic biomarkers and molecular targets is a serious problem in hepatocellular carcinoma. KCTD11, reported as a tumor suppressor, are still not well understood. In this study, KCTD11 was found low-expressed in HCC t…