Benjamin A. Fisher
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View article: Sjögren Disease: Does an Accurate Diagnosis Matter?
Sjögren Disease: Does an Accurate Diagnosis Matter? Open
View article: Hormonal risk factors and androgen and glucocorticoid dysregulation in Sjogren’s disease and non-Sjogren’s sicca
Hormonal risk factors and androgen and glucocorticoid dysregulation in Sjogren’s disease and non-Sjogren’s sicca Open
Objectives The strong female sex bias in Sjögren’s disease (SjD) remains poorly understood. We evaluated hormonal risk factors and steroidal hormones in a well-characterized cohort. Methods Newly presenting patients investigated for SjD at…
View article: Immune checkpoint inhibitor-induced inflammatory arthritis
Immune checkpoint inhibitor-induced inflammatory arthritis Open
Immune checkpoint inhibitors (ICI) used for the treatment of malignancy are associated with immune-related adverse events, which include inflammatory arthritis. ICI-induced inflammatory arthritis (ICI-IA) is a new clinical entity that may …
View article: Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution
Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution Open
View article: Primary Sjögren’s Disease: a review of unmet need, outcome measures, therapeutic advances and health economic impacts. Lessons from the NEw Clinical Endpoints in primary Sjögren’s Syndrome: an Interventional Trial based on stratifYing patients (NECESSITY) Innovative Health Initiative (IHI)
Primary Sjögren’s Disease: a review of unmet need, outcome measures, therapeutic advances and health economic impacts. Lessons from the NEw Clinical Endpoints in primary Sjögren’s Syndrome: an Interventional Trial based on stratifYing patients (NECESSITY) Innovative Health Initiative (IHI) Open
Primary Sjögren's disease (pSjD) is an autoimmune rheumatic disease involving exocrine glands and associated with high symptom burden (dryness, fatigue, pain), systemic features and salivary gland dysfunction. B-cell hyperactivity is commo…
View article: 2023 International Rome consensus for the nomenclature of Sjögren disease
2023 International Rome consensus for the nomenclature of Sjögren disease Open
View article: OP0001 COMPARATIVE ANALYSIS OF SYNOVIAL TISSUE TOPOGRAPHY BY SINGLE CELL TRANSCRIPTOMICS AND SPATIAL TRANSCRIPTOMICS REVEALS DISCRETE AND OVERLAPPING DISEASE PATHWAYS DRIVING CHECKPOINT INHIBITOR-INDUCED AND SPONTANEOUS INFLAMMATORY ARTHRITIS
OP0001 COMPARATIVE ANALYSIS OF SYNOVIAL TISSUE TOPOGRAPHY BY SINGLE CELL TRANSCRIPTOMICS AND SPATIAL TRANSCRIPTOMICS REVEALS DISCRETE AND OVERLAPPING DISEASE PATHWAYS DRIVING CHECKPOINT INHIBITOR-INDUCED AND SPONTANEOUS INFLAMMATORY ARTHRITIS Open
View article: POS0094 PHARMACODYNAMIC ACTIVITY OF JNJ-67484703 IN RHEUMATOID ARTHRITIS, ULCERATIVE COLITIS AND SJOGREN'S DISEASE (PARIS): RESULTS OF A PHASE II PROOF OF BIOLOGY TRIAL
POS0094 PHARMACODYNAMIC ACTIVITY OF JNJ-67484703 IN RHEUMATOID ARTHRITIS, ULCERATIVE COLITIS AND SJOGREN'S DISEASE (PARIS): RESULTS OF A PHASE II PROOF OF BIOLOGY TRIAL Open
View article: OP0043 Impact of socioeconomic deprivation on risk of Sjogren's disease and disease characteristics
OP0043 Impact of socioeconomic deprivation on risk of Sjogren's disease and disease characteristics Open
View article: Increasing the number of minor salivary glands from patients with Sjögren's disease improves the diagnostic and measurement precision of the histological focus score
Increasing the number of minor salivary glands from patients with Sjögren's disease improves the diagnostic and measurement precision of the histological focus score Open
For a diagnostic threshold of FS ≥1, a minimum of 5 glands should ideally be targeted. For continuous FS values, a larger number of MSGs (eg, 6) will increase reproducibility further and reduce clinical trial sample size requirements.
View article: Molecular and spatial analysis of tertiary lymphoid structures in Sjogren’s syndrome
Molecular and spatial analysis of tertiary lymphoid structures in Sjogren’s syndrome Open
View article: Are ultrasound salivary parenchymal lesions more severe in primary Sjögren patients with a longer disease duration? A cross-sectional study
Are ultrasound salivary parenchymal lesions more severe in primary Sjögren patients with a longer disease duration? A cross-sectional study Open
Objectives Salivary gland ultrasound (SGUS) has an interest in primary Sjögren’s disease (pSD) for diagnosis, but the evolution of parenchymal lesions over time is unknown. The objective of this study was to assess the severity of ultrasou…
View article: Safety and Efficacy of Ianalumab in Patients With Sjögren's Disease: 52‐Week Results From a Randomized, Placebo‐Controlled, Phase 2b Dose‐Ranging Study
Safety and Efficacy of Ianalumab in Patients With Sjögren's Disease: 52‐Week Results From a Randomized, Placebo‐Controlled, Phase 2b Dose‐Ranging Study Open
Objective The objective of this study was to report 52‐week safety and efficacy of ianalumab from phase 2b dose‐finding study in patients with Sjögren's disease (SjD). Methods Patients randomly received (1:1:1:1) ianalumab (5, 50, or 300 m…
View article: Safety and efficacy of subcutaneous iscalimab (CFZ533) in two distinct populations of patients with Sjögren's disease (TWINSS): week 24 results of a randomised, double-blind, placebo-controlled, phase 2b dose-ranging study
Safety and efficacy of subcutaneous iscalimab (CFZ533) in two distinct populations of patients with Sjögren's disease (TWINSS): week 24 results of a randomised, double-blind, placebo-controlled, phase 2b dose-ranging study Open
View article: Executive summary: British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease
Executive summary: British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease Open
Background and rationale for guideline developmentSj€ ogren disease (SD) is a chronic, auto-immune disease of unknown aetiology with significant impact on quality of life (QoL) [1].Although dryness (sicca) of the eyes and mouth are the cla…
View article: British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease
British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease Open
Sjögren disease (SD) is a chronic, autoimmune disease of unknown aetiology with significant impact on quality of life. Although dryness (sicca) of the eyes and mouth are the classically described features, dryness of other mucosal surfaces…
View article: Concomitant Sjögren’s disease as a biomarker for treatment effectiveness in rheumatoid arthritis - results from the Swiss clinical quality management cohort
Concomitant Sjögren’s disease as a biomarker for treatment effectiveness in rheumatoid arthritis - results from the Swiss clinical quality management cohort Open
Objective To investigate the clinical phenotype and treatment response in patients with rheumatoid arthritis (RA) with and without concomitant Sjögren’s disease (SjD). Methods In this observational cohort study, patients with RA from the S…
View article: Reliability Exercise of Ultrasound Salivary Glands in Sjögren’s Disease: An International Web Training Initiative
Reliability Exercise of Ultrasound Salivary Glands in Sjögren’s Disease: An International Web Training Initiative Open
View article: Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial Open
View article: The Sjögren's Working Group: The 2023 OMERACT meeting and provisional domain generation
The Sjögren's Working Group: The 2023 OMERACT meeting and provisional domain generation Open
View article: The impact of concomitant Sjögren's disease on rheumatoid arthritis disease activity: a systematic review and meta-analysis
The impact of concomitant Sjögren's disease on rheumatoid arthritis disease activity: a systematic review and meta-analysis Open
RA/SS patients appear to have higher disease activity and more functional disability than patients with RA alone. The aetiology and clinical implications of this are unclear and warrant further investigation.
View article: OC 66.5 Neutrophil Extracellular Trap Components Differentially Induce S100A8/A9 Expression on Platelets Associated with a Procoagulant Phenotype
OC 66.5 Neutrophil Extracellular Trap Components Differentially Induce S100A8/A9 Expression on Platelets Associated with a Procoagulant Phenotype Open
phosphorylation.Using computational modelling, we identified small molecules that inhibited VCAM-1/α9 interactions and neutrophil hyperactivation.
View article: Concomitant Sjögren’s disease as a biomarker for treatment effectiveness in rheumatoid arthritis - results from the Swiss Clinical Quality Management cohort
Concomitant Sjögren’s disease as a biomarker for treatment effectiveness in rheumatoid arthritis - results from the Swiss Clinical Quality Management cohort Open
Objective: To investigate the clinical phenotype and treatment response in patients with rheumatoid arthritis (RA) with and without concomitant Sjögren’s disease (SjD). Methods: In this observational cohort study, patients with RA from the…
View article: OP0130 ABATACEPT IN INDIVIDUALS AT RISK OF DEVELOPING RHEUMATOID ARTHRITIS: RESULTS FROM THE ARTHRITIS PREVENTION IN THE PRE-CLINICAL PHASE OF RA WITH ABATACEPT (APIPPRA) TRIAL
OP0130 ABATACEPT IN INDIVIDUALS AT RISK OF DEVELOPING RHEUMATOID ARTHRITIS: RESULTS FROM THE ARTHRITIS PREVENTION IN THE PRE-CLINICAL PHASE OF RA WITH ABATACEPT (APIPPRA) TRIAL Open
View article: OP0232 DEEP LEARNING ACCURATELY PREDICTS FOCUS SCORE AND DIAGNOSIS OF PRIMARY SJÖGREN SYNDROME USING LABIAL SALIVARY GLAND BIOPSIES
OP0232 DEEP LEARNING ACCURATELY PREDICTS FOCUS SCORE AND DIAGNOSIS OF PRIMARY SJÖGREN SYNDROME USING LABIAL SALIVARY GLAND BIOPSIES Open
Background The Focus Score (FS) ≥ 1 in minor labial salivary gland (LSG) biopsies is one of the 2 main items (with anti-SSA positivity) to establish the diagnosis of Primary Sjögren Syndrome's (pSS). As such, correctly assessing the FS is …
View article: A randomized, double-blind, placebo-controlled, parallel group study on the effects of a cathepsin S inhibitor in primary Sjögren’s syndrome
A randomized, double-blind, placebo-controlled, parallel group study on the effects of a cathepsin S inhibitor in primary Sjögren’s syndrome Open
Objectives Primary SS (pSS) is a chronic autoimmune disorder characterized by mucosal dryness and systemic symptoms. We tested the effects of inhibition of cathepsin S using the potent and selective inhibitor RO5459072 on disease activity …
View article: A cellular and spatial map of salivary glands at single cell resolution reveals the functional basis of tertiary lymphoid structure formation in Sjogren’s syndrome
A cellular and spatial map of salivary glands at single cell resolution reveals the functional basis of tertiary lymphoid structure formation in Sjogren’s syndrome Open
The key role of tertiary lymphoid structures in autoimmune and non-autoimmune conditions has been recently appreciated. While many of the molecular mechanisms involved in tertiary lymphoid structure (TLS) formation have been identified, th…
View article: Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases
Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases Open
View article: RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients Open
View article: Immunofibroblasts regulate LTα3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction
Immunofibroblasts regulate LTα3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction Open