Benjamin Augustine
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View article: Impact of early enteral nutrition in critically ill children: A systematic review and meta‐analysis
Impact of early enteral nutrition in critically ill children: A systematic review and meta‐analysis Open
Background This study aims to evaluate the impact of early enteral nutrition (EEN) compared with late enteral nutrition on clinical outcomes in critically ill children. Methods PubMed, Embase, and the Cochrane Library were systematically s…
View article: Protein S activity in sickle cell anaemia patients in steady state and crisis
Protein S activity in sickle cell anaemia patients in steady state and crisis Open
Background: In sickle cell anaemia, there is an ever-present risk for haemostatic abnormalities which may result in reduced levels of naturally occurring coagulation inhibitors. Protein S is a Vitamin-K dependent, γ-carboxy glutamic acid-c…
View article: Common Hepatitis B Virus Genotypes among Blood Donors in Lagos, Nigeria
Common Hepatitis B Virus Genotypes among Blood Donors in Lagos, Nigeria Open
Background: Hepatitis B virus (HBV) infection is one of the public health diseases causing global health problems. It is a leading cause of cirrhosis and hepatocellular carcinoma. Blood transfusion is a major route of its transmission and …
View article: Assessment of serpin A5 levels and coagulation parameters of sickle cell anemia patients during bone pain vaso-occlusive crisis and steady state
Assessment of serpin A5 levels and coagulation parameters of sickle cell anemia patients during bone pain vaso-occlusive crisis and steady state Open
Background Sickle cell anemia (SCA) is an inherited disorder linked to numerous complications including vaso-occlusive bone pain crisis. It is also associated with hypercoagulability and thromboembolic complications as a result of an imbal…
View article: Ferritin and transferrin levels of the elderly population at Lagos State university teaching hospital, Ikeja, Lagos, Nigeria
Ferritin and transferrin levels of the elderly population at Lagos State university teaching hospital, Ikeja, Lagos, Nigeria Open
Background: The elderly have limited regenerative abilities thus predisposing them to various diseases. Measuring both serum ferritin and transferrin serve as biomarkers of iron deficiency. This study, using enzyme-linked immunosorbent ass…
View article: Plasma Cell Leukaemia: Rare Presentation Of Relapse Multiple Myeloma: A Case Report And Literature Review
Plasma Cell Leukaemia: Rare Presentation Of Relapse Multiple Myeloma: A Case Report And Literature Review Open
Background: Plasma cell leukaemia (PCL) is a very rare and aggressive clinical variant of plasma cell dyscrasias with a dismal prognosis. Not less than 28% of patients die within one month after diagnosis. It could arise de novo and is kno…
View article: Health related quality of life among adults living with sickle cell disease in Lagos, Nigeria
Health related quality of life among adults living with sickle cell disease in Lagos, Nigeria Open
Background: Sickle cell disease (SCD) is an inherited haemoglobinopathy which involves the inheritance of haemoglobin S with any other abnormal haemoglobin from both parents. Health related quality of life (HRQOL) provides the patient’s vi…
View article: Superoxide dismutase activity in sickle cell anemia patients during crisis and in steady State
Superoxide dismutase activity in sickle cell anemia patients during crisis and in steady State Open
INTRODUCTION: Sickle cell anemia is associated with intense oxidative stress, and optimal antioxidant levels are essential to prevent continuous oxidant tissue damage. The role of oxidant damage to red blood cells in sickle cell anemia (SC…
View article: The prevalence of occult hepatitis B infection among blood donors in Lagos, Nigeria
The prevalence of occult hepatitis B infection among blood donors in Lagos, Nigeria Open
The low prevalence (3%) of occult HBV seen in our study does not make it cost-effective to routinely screen blood donors or the general population for HBV infection using DNA polymerase chain reaction.
View article: Pentazocine addiction among sickle cell disease patients and perception of its use among health-care workers
Pentazocine addiction among sickle cell disease patients and perception of its use among health-care workers Open
BACKGROUND: Prolonged use of pentazocine in sickle cell disease (SCD) because of chronic pain may result in mental dependence (addiction) and/or physical dependence leading to withdrawal symptoms on suddenly stopping its use. This study wa…
View article: Towards 2030 target for hepatitis B and C viruses elimination: Assessing the validity of predonation rapid diagnostic tests versus enzyme-linked immunosorbent assay in state hospitals in Kaduna, Nigeria
Towards 2030 target for hepatitis B and C viruses elimination: Assessing the validity of predonation rapid diagnostic tests versus enzyme-linked immunosorbent assay in state hospitals in Kaduna, Nigeria Open
Predonation RDTs screening of blood donor samples for hepatitis B virus and HCV in hospital donation units performed poorly compared to quality-assured ELISA screening in Kaduna. The risk of transmitting viral hepatitis through blood trans…
View article: On artherogenic index of plasma in sickle cell anaemia patients
On artherogenic index of plasma in sickle cell anaemia patients Open
AIP value is higher in sickle cell anaemia than controls, the former have lower mean values of TC, HDL and LDL and higher mean values of TG and VLDL.
View article: LIPID PROFILE AND DISEASE SEVERITY IN SICKLE CELL DISEASE PATIENTS IN LAGOS STATE. NIGERIA
LIPID PROFILE AND DISEASE SEVERITY IN SICKLE CELL DISEASE PATIENTS IN LAGOS STATE. NIGERIA Open
Background: Sickle cell anaemia is an autosomal recessive disorder that arises due to the substitution of glutamic acid with valine. This occurs at position 6 of the haemoglobin b chain, resulting in the synthesis of abnormal haemoglobin a…
View article: Prognostic factors and outcome of management of ischemic priapism in Zaria, Nigeria
Prognostic factors and outcome of management of ischemic priapism in Zaria, Nigeria Open
Priapism is a disease of the young, mostly sickle cell anemic patients. Late presentation remains the norm in our environment, hence a higher incidence of ED. The distal penile shunt is an effective means of achieving detumescence even wit…
View article: An assessment of knowledge, awareness, and attitude of undergraduates toward sickle cell disease in Lagos, Nigeria
An assessment of knowledge, awareness, and attitude of undergraduates toward sickle cell disease in Lagos, Nigeria Open
The awareness of SCD among the students is high but this awareness did not translate to good overall knowledge about the disease. This underscores the importance of increased public health education on SCD, in order to increase the knowled…