Benjamin Bertin
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View article: The transcription factor Traffic jam orchestrates the somatic piRNA pathway in Drosophila ovaries
The transcription factor Traffic jam orchestrates the somatic piRNA pathway in Drosophila ovaries Open
The PIWI-interacting RNA (piRNA) pathway is essential for transposable element (TE) silencing in animal gonads. While the transcriptional regulation of piRNA pathway components in germ cells has been documented in mice and flies, their con…
View article: The transcription factor Traffic jam orchestrates the somatic piRNA pathway in <i>Drosophila</i> ovaries
The transcription factor Traffic jam orchestrates the somatic piRNA pathway in <i>Drosophila</i> ovaries Open
The PIWI-interacting RNA (piRNA) pathway is essential for transposable element (TE) silencing in animal gonads. While the transcriptional regulation of piRNA pathway components in germ cells has been documented in mice and flies, their con…
View article: An Overview of the Influence of Breastfeeding on the Development of Inflammatory Bowel Disease
An Overview of the Influence of Breastfeeding on the Development of Inflammatory Bowel Disease Open
The first 1000 days of life is a critical period that contributes significantly to the programming of an individual’s future health. Among the many changes that occur during this period early in life, there is growing evidence that the est…
View article: An Overview of the Influence of Breastfeeding on the Developement of Inflammatory Bowel Disease
An Overview of the Influence of Breastfeeding on the Developement of Inflammatory Bowel Disease Open
The first 1000 days of life is a critical period that contributes significantly to the programming of an individual's future health. Among the many changes that occur during this period, there is growing evidence that the establishmen…
View article: Appropriate ischemic criteria for type 4a myocardial infarction: insights from the ALPHEUS trial
Appropriate ischemic criteria for type 4a myocardial infarction: insights from the ALPHEUS trial Open
Background Different troponin thresholds have been proposed to define periprocedural myocardial injury based on post percutaneous coronary intervention (PCI) troponin increase only, whereas the definition of type 4a myocardial infarction (…
View article: Muscle‐specific, liver‐detargeted <scp>adeno‐associated virus</scp> gene therapy rescues Pompe phenotype in adult and neonate <scp><i>Gaa</i><sup>−/−</sup></scp> mice
Muscle‐specific, liver‐detargeted <span>adeno‐associated virus</span> gene therapy rescues Pompe phenotype in adult and neonate <span><i>Gaa</i><sup>−/−</sup></span> mice Open
Pompe disease (PD) is a neuromuscular disorder caused by acid α‐glucosidase (GAA) deficiency. Reduced GAA activity leads to pathological glycogen accumulation in cardiac and skeletal muscles responsible for severe heart impairment, respira…
View article: Reactivation of an Endogenous retrovirus in Drosophila ovarian somatic tissue: from germline invasion to taming
Reactivation of an Endogenous retrovirus in Drosophila ovarian somatic tissue: from germline invasion to taming Open
Endogenous retroviruses (ERVs) are transposable elements (TEs) related to infectious retroviruses. In eukaryotes, ERV-related TEs occupy large parts of the genome, but it is unclear what led to such successful genome invasion. We created c…
View article: The Class I HDAC Inhibitor, MS-275, Prevents Oxaliplatin-Induced Chronic Neuropathy and Potentiates Its Antiproliferative Activity in Mice
The Class I HDAC Inhibitor, MS-275, Prevents Oxaliplatin-Induced Chronic Neuropathy and Potentiates Its Antiproliferative Activity in Mice Open
Oxaliplatin, the first-line chemotherapeutic agent against colorectal cancer (CRC), induces peripheral neuropathies, which can lead to dose limitation and treatment discontinuation. Downregulation of potassium channels, which involves hist…
View article: A polarized nucleus-cytoskeleton-ECM connection controls collective migration and cardioblasts number in<i>Drosophila</i>
A polarized nucleus-cytoskeleton-ECM connection controls collective migration and cardioblasts number in<i>Drosophila</i> Open
The formation of the cardiac tube is a remarkable example of complex morphogenetic process conserved from invertebrates to humans. It involves coordinated collective migration of contralateral rows of cardiac cells. The molecular processes…
View article: Contribution of the Gut Microbiota in P28GST-Mediated Anti-Inflammatory Effects: Experimental and Clinical Insights
Contribution of the Gut Microbiota in P28GST-Mediated Anti-Inflammatory Effects: Experimental and Clinical Insights Open
An original immuno-regulatory strategy against inflammatory bowel diseases based on the use of 28 kDa glutathione S-transferase (P28GST), a unique schistosome protein, was recently proposed. Improvement of intestinal inflammation occurs th…
View article: The Expression of the Short Isoform of Thymic Stromal Lymphopoietin in the Colon Is Regulated by the Nuclear Receptor Peroxisome Proliferator Activated Receptor-Gamma and Is Impaired during Ulcerative Colitis
The Expression of the Short Isoform of Thymic Stromal Lymphopoietin in the Colon Is Regulated by the Nuclear Receptor Peroxisome Proliferator Activated Receptor-Gamma and Is Impaired during Ulcerative Colitis Open
The etiology of inflammatory bowel diseases remains largely unknown. We previously demonstrated that the expression of the peroxisome proliferator activated receptor-gamma (PPARγ) is downregulated in colonic epithelial cells of patients wi…