Benjamin Bray
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View article: Impact of COVID-19 infection on social care use in people over 50 years of age: a matched cohort study in North-West London
Impact of COVID-19 infection on social care use in people over 50 years of age: a matched cohort study in North-West London Open
Objectives To estimate the impact of COVID-19 infection on the requirement for social care services among adults aged ≥50 years in North-West London. Design Population-based matched cohort study using linked routinely collected electronic …
View article: Extension and external validation of mapping between the Mini‐Mental State Examination and the Clinical Dementia Rating scale in patients with Alzheimer's disease
Extension and external validation of mapping between the Mini‐Mental State Examination and the Clinical Dementia Rating scale in patients with Alzheimer's disease Open
INTRODUCTION We aimed to develop and externally validate a mapping to translate Mini‐Mental State Examination (MMSE) scores to Clinical Dementia Rating scale Sum of Boxes (CDR‐SB) scores in patients with Alzheimer's disease (AD). METHODS W…
View article: The associations between multimorbidity, healthcare resource utilisation and costs in individuals with Alzheimer's disease dementia
The associations between multimorbidity, healthcare resource utilisation and costs in individuals with Alzheimer's disease dementia Open
Background: Multimorbidity (having two or more comorbidities), is common among people with dementia and associated with lower survival and increased healthcare use. We aimed to identify comorbidity clusters in people living with Alzheimer’…
View article: The impact of mild cognitive impairment on healthcare utilization and costs: A UK Biobank study
The impact of mild cognitive impairment on healthcare utilization and costs: A UK Biobank study Open
INTRODUCTION Mild cognitive impairment (MCI) is common in older adults, but the burden on patients and health systems is not well understood. We aimed to estimate the impact of MCI on healthcare utilization and costs. METHODS This was a ma…
View article: The impact of COVID-19 infection on social care use in people over 50 years of age: a matched cohort study
The impact of COVID-19 infection on social care use in people over 50 years of age: a matched cohort study Open
Objectives To estimate the impact of COVID-19 infection on the requirement for social care services among adults aged ≥50 years in North-West London. Design Population based matched cohort study using linked routinely collected electronic …
View article: Characterising subpopulations of patients with Alzheimer’s disease dementia who have high healthcare utilisation and costs
Characterising subpopulations of patients with Alzheimer’s disease dementia who have high healthcare utilisation and costs Open
Background How and why healthcare utilisation and costs vary between patients with Alzheimer’s disease dementia (ADD) is not well understood but is important in ensuring that efforts to improve the diagnosis and treatment of ADD are priori…
View article: Mapping between the Mini‐Mental State Examination and the Clinical Dementia Rating scale for Patients with Alzheimer’s Disease: An External Validation Study
Mapping between the Mini‐Mental State Examination and the Clinical Dementia Rating scale for Patients with Alzheimer’s Disease: An External Validation Study Open
Background The Clinical Dementia Rating scale Sum of Boxes (CDR‐SB) measure is commonly used in specialist research settings and clinical trials. In clinical practice, shorter cognitive assessments, such as the Mini‐Mental State Examinatio…
View article: PP12 Projecting The Potential Impact Of Disease-Modifying Therapies For Alzheimer’s Disease On The Carbon Emissions From Hospital Bed-Days in the UK
PP12 Projecting The Potential Impact Of Disease-Modifying Therapies For Alzheimer’s Disease On The Carbon Emissions From Hospital Bed-Days in the UK Open
Introduction Disease-modifying therapies (DMTs) for Alzheimer’s disease (AD) are emerging treatment options. This study aimed to estimate the potential health system and associated environmental impacts of DMTs by modeling future bed-days …
View article: Routine measurement of cardiometabolic disease risk factors in primary care in England before, during, and after the COVID-19 pandemic: A population-based cohort study
Routine measurement of cardiometabolic disease risk factors in primary care in England before, during, and after the COVID-19 pandemic: A population-based cohort study Open
Background This study estimated to what extent the number of measurements of cardiometabolic risk factors (e.g., blood pressure, cholesterol, glycated haemoglobin) were impacted by the COVID-19 pandemic and whether these have recovered to …
View article: R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 15
R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 15 Open
In this latest update we discuss real-world evidence (RWE) guidance from the leading oncology professional societies, the American Society of Clinical Oncology and the European Society for Medical Oncology, and the PRINCIPLED practical gui…
View article: Real world outcomes, healthcare utilisation and costs of Alzheimer's disease in England
Real world outcomes, healthcare utilisation and costs of Alzheimer's disease in England Open
Background: Evidence on health and social care resource utilisation and associated costs, and how this varies across people with Alzheimer's disease (AD) dementia is limited. Methods: Retrospective cohort, using the Discover dataset, which…
View article: R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 14
R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 14 Open
In this latest update we highlight: a publication from the US FDA regarding the definitions of real-world data (RWD) and real-world evidence (RWE); a publication from academic researchers on a demonstration project for target trial emulati…
View article: The impact of the COVID-19 pandemic on cardiovascular disease prevention and corresponding geographical inequalities in England: interrupted time series analysis
The impact of the COVID-19 pandemic on cardiovascular disease prevention and corresponding geographical inequalities in England: interrupted time series analysis Open
Background There has been disruption to the detection and management of those with hypertension and atrial fibrillation (AF) during the COVID-19 pandemic. This is likely to vary geographically and could have implications for future mortali…
View article: PP140 Burden of Illness And Health Care Costs In People with Alzheimer’s Disease
PP140 Burden of Illness And Health Care Costs In People with Alzheimer’s Disease Open
Introduction Alzheimer’s disease (AD), the most common cause of dementia, is becoming increasingly prevalent worldwide. Understanding the current burden of AD is important in health economic evaluations of new therapies. We aimed to estima…
View article: Real‐world use and cost of health and social care services of 18,116 patients living with Alzheimer’s disease
Real‐world use and cost of health and social care services of 18,116 patients living with Alzheimer’s disease Open
Background The increasing prevalence of Alzheimer’s disease (AD) will substantially impact health and social care systems worldwide. In this study, we aimed to estimate the real‐world use and cost of health and social care services in a la…
View article: Developing and externally validating a machine learning risk prediction model for 30-day mortality after stroke using national stroke registers in the UK and Sweden
Developing and externally validating a machine learning risk prediction model for 30-day mortality after stroke using national stroke registers in the UK and Sweden Open
Objectives We aimed to develop and externally validate a generalisable risk prediction model for 30-day stroke mortality suitable for supporting quality improvement analytics in stroke care using large nationwide stroke registers in the UK…
View article: R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 13
R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 13 Open
In this latest update we highlight a report from the European Medicines Agency on their use of real-world evidence (RWE) in decision making, RWE reporting guidance from the Canadian Agency for Drugs and Technologies in Health and highlight…
View article: R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 12
R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 12 Open
In this latest update we highlight the final results from the RCT-DUPLICATE initiative, the publication of guidance from Haute Autorité de Santé (HAS), the joint viewpoint from the Institute for Quality and Efficiency in HealthCare (IQWIG)…
View article: R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 11
R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 11 Open
In this latest update we highlight a study from the REPEAT initiative that evaluates the reproducibility of real-world data studies, the publication of the HARPER Protocol Template developed by a joint ISPE/ISPOR taskforce, and discuss rec…
View article: Association of COVID-19 With Major Arterial and Venous Thrombotic Diseases: A Population-Wide Cohort Study of 48 Million Adults in England and Wales
Association of COVID-19 With Major Arterial and Venous Thrombotic Diseases: A Population-Wide Cohort Study of 48 Million Adults in England and Wales Open
Background: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a prothrombotic state, but long-term effects of COVID-19 on incidence of vascular diseases are unclear. Methods: We studied vascular diseases a…
View article: COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records
COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records Open
BACKGROUND: Updatable estimates of COVID-19 onset, progression, and trajectories underpin pandemic mitigation efforts. To identify and characterise disease trajectories, we aimed to define and validate ten COVID-19 phenotypes from nationwi…
View article: Do Stroke Care Processes Modify Clinical Outcomes in Patients with Stroke-Associated Pneumonia? A Registry Cohort Study in England and Wales
Do Stroke Care Processes Modify Clinical Outcomes in Patients with Stroke-Associated Pneumonia? A Registry Cohort Study in England and Wales Open
Introduction: It is not known whether modern stroke unit care reduces the impact of stroke complications, such as stroke-associated pneumonia (SAP), on clinical outcomes. We investigated the relationship between SAP and clinical outcomes, …
View article: The Timing of Stroke Care Processes and Development of Stroke Associated Pneumonia: A National Registry Cohort Study
The Timing of Stroke Care Processes and Development of Stroke Associated Pneumonia: A National Registry Cohort Study Open
Introduction Timely stroke care can result in significant improvements in stroke recovery. However, little is known about how stroke care processes relate to complications such as the development of stroke associated pneumonia (SAP). Here …
View article: Investigating the association between inpatient stroke therapy and disability, destination on discharge, length of stay and mortality: a prospective cohort study using the Sentinel Stroke National Audit Programme
Investigating the association between inpatient stroke therapy and disability, destination on discharge, length of stay and mortality: a prospective cohort study using the Sentinel Stroke National Audit Programme Open
Objective ‘More is better’ is a recognised mantra within stroke therapy, however, this has been developed in patients receiving long term rehabilitation. We investigated the relationship between amount of therapy received (from therapists …
View article: Supplementary Material for: Do Stroke Care Processes Modify Clinical Outcomes in Patients with Stroke-Associated Pneumonia? A Registry Cohort Study in England and Wales
Supplementary Material for: Do Stroke Care Processes Modify Clinical Outcomes in Patients with Stroke-Associated Pneumonia? A Registry Cohort Study in England and Wales Open
Introduction: It is not known whether modern stroke unit care reduces the impact of stroke complications, such as stroke-associated pneumonia (SAP), on clinical outcomes. We investigated the relationship between SAP and clinical outcomes, …
View article: Are Differences in Dysphagia Assessment, Oral Care Provision, or Nasogastric Tube Insertion Associated with Stroke-Associated Pneumonia? A Nationwide Survey Linked to National Stroke Registry Data
Are Differences in Dysphagia Assessment, Oral Care Provision, or Nasogastric Tube Insertion Associated with Stroke-Associated Pneumonia? A Nationwide Survey Linked to National Stroke Registry Data Open
Introduction: Stroke-associated pneumonia (SAP) is a common complication associated with poor outcomes. Early dysphagia screening and specialist assessment is associated with a reduced risk of SAP. Evidence about oral care and nasogastric …
View article: Association of COVID-19 with arterial and venous vascular diseases: a population-wide cohort study of 48 million adults in England and Wales
Association of COVID-19 with arterial and venous vascular diseases: a population-wide cohort study of 48 million adults in England and Wales Open
Importance The long-term effects of COVID-19 on the incidence of vascular diseases are unclear. Objective To quantify the association between time since diagnosis of COVID-19 and vascular disease, overall and by age, sex, ethnicity, and pr…
View article: Power of big data to improve patient care in gastroenterology
Power of big data to improve patient care in gastroenterology Open
Big data is defined as being large, varied or frequently updated, and usually generated from real-world interaction. With the unprecedented availability of big data, comes an obligation to maximise its potential for healthcare improvements…