Ben J. Boyd
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Effect of the Chemical Structure of Ionic Glycolipids on Their Lyotropic Aqueous Phase Behavior Open
This study examines the self-assembly and lyotropic aqueous phase behavior of galactose- (GC) and rhamnose-based (RC) bioinspired glycolipids with C10 and C14 alkyl chains using small-angle X-ray scattering and wide-angle X-ray scattering …
View article: Hydrophobic drug particles adopt a complex biomolecular corona in ex vivo gastrointestinal fluids
Hydrophobic drug particles adopt a complex biomolecular corona in ex vivo gastrointestinal fluids Open
The adsorption of proteins and other biomolecules onto particles at the blood-particle interface, resulting in the formation of a biomolecular corona, is an established research area and can form the basis for a formulation concept to modi…
Decoding Protein Corona Through Synchrotron-Based Small-Angle X-Ray Scattering Open
Nanoparticles (NPs) in biological environments rapidly become coated with a dynamic biomolecular layer known as the protein corona (PC), significantly influencing their biological identity and functionality. Traditional methods used to cha…
Spatially-offset Raman spectroscopy for the non-invasive, real-time characterization of in situ skin implant formation and drug release kinetics Open
In situ forming implants (ISFIs) present a promising approach for sustained parenteral drug delivery, offering reduced first pass metabolism, fewer systemic side effects, and improved patient compliance. This study investigates defocused s…
Phospholipase A2 induces structural changes in phospholipid-containing cubosomes Open
The functionalization of cubosomes for their use in drug delivery, bioimaging, and biosensing can be achieved by incorporating molecules that are sensitive to physiological conditions, such as phospholipids. Considering this, it is relevan…
View article: Asymmetric nanocapsules via elongated liposome templated polymerization (ELTP) mediated by RAFT polymerization
Asymmetric nanocapsules via elongated liposome templated polymerization (ELTP) mediated by RAFT polymerization Open
Polymeric nanocapsules comprised of hydrophobic shells and hollow aqueous interiors are an extremely useful class of nanomaterial, particularly in the encapsulation and controlled delivery of hydrophilic cargo. Generally prepared via dropl…
View article: Recent Advances and Challenges in the Development and Delivery of Antiprotozoal Agents Against Trichomoniasis
Recent Advances and Challenges in the Development and Delivery of Antiprotozoal Agents Against Trichomoniasis Open
Trichomoniasis, a prevalent sexually transmitted parasitic infection caused by Trichomonas vaginalis , represents a significant public health concern with transboundary implications. In males, trichomoniasis is often asymptomatic, whereas …
Metabolic glycan labelling with bio-orthogonal targeting and its potential in drug delivery Open
New modes of targeted drug delivery are emerging with promise of enhancing therapeutic efficacy while reducing side effects. This review examines the landscape of metabolic glycan labelling-a technique gaining traction for its potential in…
View article: Smart control lipid-based nanocarriers for fine-tuning gut hormone secretion
Smart control lipid-based nanocarriers for fine-tuning gut hormone secretion Open
Modulating the endogenous stores of gastrointestinal hormones is considered a promising strategy to mimic gut endocrine function, improving metabolic dysfunction. Here, we exploit mouse and human knock-in and knockout intestinal organoids …
Human milk improves the oral bioavailability of the poorly water-soluble drug clofazimine Open
Clofazimine is an emerging drug for the treatment of cryptosporidiosis in infants. As a poorly water-soluble drug, the formulation of clofazimine in age-appropriate vehicles is challenging and often results in the use of off-label formulat…
Low-frequency Raman spectroscopy as a new tool for understanding the behaviour of ionisable compounds in dispersed mesophases Open
The intensity of the VDOS signal of MO + OA mesophases scaled with phase-specific transformations, such as from the bi-continuous cubic Im3¯m phase (V2) or lamellar-based vesicles to the reversed hexagonal p6m phase (H2). For NG subtle cha…
View article: The “gut” corona at the surface of nanoparticles is dependent on exposure to bile salts and phospholipids
The “gut” corona at the surface of nanoparticles is dependent on exposure to bile salts and phospholipids Open
The formation of raspberry-like structures was identified, with bile micelles adopting ellipsoidal shapes around the nanoparticles, as opposed to a surface covered with a uniform corona (i.e., core-shell structure). Assay quantification an…
Comparing the lipid self-assembly behaviour and fatty acid composition of plant-based drinks to bovine milk during digestion Open
In this study, a static in-vitro digestion model was coupled with synchrotron small-angle X-ray scattering (SAXS) to compare the lipid self-assembly behaviour of plant-based drinks and bovine milk during digestion. The diffraction profiles…
View article: Adsorption of bile salts onto crystalline ritonavir particles under simulated gastrointestinal conditions
Adsorption of bile salts onto crystalline ritonavir particles under simulated gastrointestinal conditions Open
The formation of a biomolecular corona on nanoparticles in blood is a well-known phenomenon influencing in vivo performance. Analogous phenomena in other biological fluids, such as the formation of a gastrointestinal (GI) corona, remain un…
View article: Asymmetric Nanocapsules via Elongated Liposome Templated Polymerization (ELTP) Mediated by RAFT Polymerization
Asymmetric Nanocapsules via Elongated Liposome Templated Polymerization (ELTP) Mediated by RAFT Polymerization Open
Polymeric nanocapsules comprised of hydrophobic shells and hollow aqueous interiors are an extremely useful class of nanomaterial, particularly in the encapsulation and controlled delivery of hydrophilic cargo. Generally prepared via dropl…
Stimuli-responsive drug delivery systems for inflammatory skin conditions Open
Inflammatory skin conditions highly influence the quality of life of the patients suffering from these disorders. Symptoms include red, itchy and painful skin lesions, which are visible to the rest of the world, causing stigmatization and …
Compartmentalised enzyme-induced phase transformations in self-assembling lipid systems Open
PLM revealed the growth of an aligned inverse hexagonal phase (H2), and with SAXS showed that this phase transformation and alignment resulted from enzymatic digestion. A subsequent partial transformation from H2 to inverse bicontinuous cu…
Infant formula as a solid lipid dose form for enhancement of the oral bioavailability of cannabidiol for paediatric patients Open
Cannabinoids can save paediatric patients from harmful psychological conditions caused by epilepsy. However, the limited aqueous solubility of the drug presents a limitation to oral absorption and bioavailability. Previous studies have sho…
Effect of Hepatic Impairment on the Pharmacokinetics of Fenfluramine and Norfenfluramine Open
Fenfluramine (Fintepla ® ) is approved for the treatment of seizures associated with the rare epileptic encephalopathies Dravet syndrome and Lennox–Gastaut syndrome. Fenfluramine is extensively metabolized; thus, patients with hepatic impa…
Stability of extemporaneously prepared clofazimine oral suspensions Open
Background Clofazimine is recommended as a treatment for tuberculosis in infants. Extemporaneously prepared clofazimine oral suspensions are more appropriate dosage forms for infants than tablets, however no data exist to inform appropriat…
Enhanced clearance of C. muridarum infection using azithromycin-loaded liposomes Open
Chlamydia trachomatis is an intracellular bacterium which infects around 129 million people annually. Despite similar infection rates between sexes, most research investigating the effects of chlamydial infection on fertility has focused o…
View article: Liposomal formulation of a new antifungal hybrid compound provides protection against <i>Candida auris</i> in the <i>ex vivo</i> skin colonization model
Liposomal formulation of a new antifungal hybrid compound provides protection against <i>Candida auris</i> in the <i>ex vivo</i> skin colonization model Open
The newly emerged pathogen, Candida auris , presents a serious threat to public health worldwide. This multidrug-resistant yeast often colonizes and persists on the skin of patients, can easily spread from person to person, and can cause l…
Dissolution of pain-relief drugs: Does beverage choice matter? Open
Oral administration continues to be the most common route for drug delivery with the majority of approved medicines being tablets and capsule dosage forms. Standardised pharmacopeial media are typically used to test tablet dissolution in v…