Benjamin C. Kennedy
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View article: Intravenous AAV9- <i>ATP7A</i> plus subcutaneous copper histidinate optimizes outcomes in a lethal Menkes disease mouse model
Intravenous AAV9- <i>ATP7A</i> plus subcutaneous copper histidinate optimizes outcomes in a lethal Menkes disease mouse model Open
Menkes disease is an X-linked recessive condition characterized by seizures, failure to thrive, and rapid, progressive neurodegeneration beginning within weeks after birth. Death usually occurs by 3 years of age. The disorder is caused by …
View article: Toe Walking in a Formerly Preterm Child: Is it Just Cerebral Palsy?
Toe Walking in a Formerly Preterm Child: Is it Just Cerebral Palsy? Open
View article: Interictal spikes and evoked cortical potentials share common spatiotemporal constraints in human epilepsy
Interictal spikes and evoked cortical potentials share common spatiotemporal constraints in human epilepsy Open
Interictal epileptiform discharges (IEDs) are pathologic hallmarks of epilepsy which frequently arise and spread through networks of functionally-connected brain regions. Recent studies demonstrate that the sequential recruitment of brain …
View article: Two-year outcomes following modified transsylvian peri-insular hemispherotomy
Two-year outcomes following modified transsylvian peri-insular hemispherotomy Open
View article: Multiple subpial transections with concomitant responsive neurostimulation of the insula: illustrative case
Multiple subpial transections with concomitant responsive neurostimulation of the insula: illustrative case Open
BACKGROUND Focal epilepsy arising from the eloquent cortex can be treated with palliative surgical interventions such as multiple subpial transection (MST) or responsive neurostimulation (RNS). These techniques can be performed to reduce t…
View article: Salvage Trans‐Sylvian Peri‐Insular Hemispherotomy After Embolic Hemispherectomy
Salvage Trans‐Sylvian Peri‐Insular Hemispherotomy After Embolic Hemispherectomy Open
Background Hemispherectomy and hemispherotomy represent well‐established treatments for drug‐resistant hemispheric epilepsy. An alternative endovascular procedure has been explored for cases with challenging surgical anatomy, which seeks t…
View article: Risks from parasiticides to invertebrate pets
Risks from parasiticides to invertebrate pets Open
View article: Mapping the Epileptogenic Brain Using Low-Frequency Stimulation: Two Decades of Advances and Uncertainties
Mapping the Epileptogenic Brain Using Low-Frequency Stimulation: Two Decades of Advances and Uncertainties Open
Cortical stimulation is the process of delivering brief pulses of electrical current and visualizing the distributed pattern of evoked responses across the brain. Compared to high-frequency stimulation, which has long been used for seizure…
View article: Comparative molecular landscapes of immature neurons in the mammalian dentate gyrus across species reveal special features in humans
Comparative molecular landscapes of immature neurons in the mammalian dentate gyrus across species reveal special features in humans Open
Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity, learning and memory, but their evolutionary changes across species and specialized features in humans remain poorly understood. He…
View article: Motor Outcome After Posterior Insular Resection for Pediatric Epilepsy
Motor Outcome After Posterior Insular Resection for Pediatric Epilepsy Open
The increasingly widespread use of stereo-EEG in the pre-surgical evaluation has led to greater recognition of the insula as both a source and surgical target for drug-resistant epilepsy. Clinicians have long appreciated the challenges of …
View article: Brain-wide neuronal circuit connectome of human glioblastoma
Brain-wide neuronal circuit connectome of human glioblastoma Open
View article: Whole genome sequencing from dried blood spots for newborn screening of Menkes disease and 36 other actionable inherited neurometabolic disorders
Whole genome sequencing from dried blood spots for newborn screening of Menkes disease and 36 other actionable inherited neurometabolic disorders Open
View article: Co-activation of interictal epileptiform discharges localizes seizure onset zone and fluctuates with brain state
Co-activation of interictal epileptiform discharges localizes seizure onset zone and fluctuates with brain state Open
Seizures are increasingly understood as emergent phenomena of complex, pathophysiologic networks. Interictal spikes are ubiquitous markers of paroxysmal synchronization in the epileptic brain and have been shown to co-activate between brai…
View article: Whole Genome Sequencing from Dried Blood Spots for Newborn Screening of Menkes Disease and 36 Other Actionable Inherited Neurometabolic Disorders
Whole Genome Sequencing from Dried Blood Spots for Newborn Screening of Menkes Disease and 36 Other Actionable Inherited Neurometabolic Disorders Open
Tandem mass spectrometry is currently used by the Ohio Department of Health to screen newborn infants for 36 medically actionable inborn errors of metabolism. As a complementary test for infants with abnormal biochemical screens, whole gen…
View article: Endoscopic endonasal resection of olfactory tract hamartoma for pediatric epilepsy
Endoscopic endonasal resection of olfactory tract hamartoma for pediatric epilepsy Open
Background Non-hypothalamic glioneural hamartomas are rare entities known to cause medically refractory epilepsy. Olfactory bulb hamartomas, in particular, are exceptionally rare. Methods We describe a case of an olfactory bulb hamartoma t…
View article: Urban Agriculture and the Neighbourhood Context: A Geodemographic Approach to the City of Toronto
Urban Agriculture and the Neighbourhood Context: A Geodemographic Approach to the City of Toronto Open
This study seeks to create a geodemographic classification of the City of Toronto in Ontario, Canada at the Dissemination Areas level in order to assess the distribution of urban agriculture projects across the city. The study uses an iter…
View article: Urban Agriculture and the Neighbourhood Context: A Geodemographic Approach to the City of Toronto
Urban Agriculture and the Neighbourhood Context: A Geodemographic Approach to the City of Toronto Open
This study seeks to create a geodemographic classification of the City of Toronto in Ontario, Canada at the Dissemination Areas level in order to assess the distribution of urban agriculture projects across the city. The study uses an iter…
View article: Transorbital intraoperative electrocorticography-guided surgical resection for medically refractory developmental epileptic encephalopathy with spike-wave activation in sleep
Transorbital intraoperative electrocorticography-guided surgical resection for medically refractory developmental epileptic encephalopathy with spike-wave activation in sleep Open
Developmental epileptic encephalopathy with spike-wave activation in sleep (DEE-SWAS) is an epilepsy syndrome of childhood characterized by developmental delay or regression with significant abnormal epileptiform activity during sleep. In …
View article: Systematic review and cumulative analysis of clinical properties of BRAF V600E mutations in PLNTY histological samples
Systematic review and cumulative analysis of clinical properties of BRAF V600E mutations in PLNTY histological samples Open
Polymorphous low-grade neuroepithelial tumors of the young (PLNTY) represent a rare pediatric-type tumor that most commonly presents as medically refractory epilepsy. PLNTY has only recently been recognized as a distinct clinical entity, h…
View article: Supplementary Tables 1 through 7 from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression
Supplementary Tables 1 through 7 from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression Open
XLSX - 1231K, Supplementary Table 1: List of genes deleted in 75 to 100% of the end-stage *PTEN tumors Supplementary Table 2: List of genes showing copy number gains in *PTEN end-stage and *PTEN/p53 mouse tumors. Supplementary Table 3: Gen…
View article: Data from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression
Data from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression Open
Proneural glioblastoma is defined by an expression pattern resembling that of oligodendrocyte progenitor cells and carries a distinctive set of genetic alterations. Whether there is a functional relationship between the proneural phenotype…
View article: Supplementary Figure Legend from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression
Supplementary Figure Legend from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression Open
PDF - 106K, Contains the legends for Supplementary Figures 1-6 and Supplementary Tables 1-7.
View article: Supplementary Tables 1 through 7 from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression
Supplementary Tables 1 through 7 from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression Open
XLSX - 1231K, Supplementary Table 1: List of genes deleted in 75 to 100% of the end-stage *PTEN tumors Supplementary Table 2: List of genes showing copy number gains in *PTEN end-stage and *PTEN/p53 mouse tumors. Supplementary Table 3: Gen…
View article: Data from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression
Data from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression Open
Proneural glioblastoma is defined by an expression pattern resembling that of oligodendrocyte progenitor cells and carries a distinctive set of genetic alterations. Whether there is a functional relationship between the proneural phenotype…
View article: Supplementary Figures 1 through 6 from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression
Supplementary Figures 1 through 6 from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression Open
PDF - 1816K, Supplementary Figure 1: CGH probe for Cre-mediated Pten deletion provides a surrogate of tumor DNA content for mouse tumors. Supplementary Figure 2: The genomic architecture of mouse tumor gene deletions suggests independent s…
View article: Supplementary Figures 1 through 6 from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression
Supplementary Figures 1 through 6 from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression Open
PDF - 1816K, Supplementary Figure 1: CGH probe for Cre-mediated Pten deletion provides a surrogate of tumor DNA content for mouse tumors. Supplementary Figure 2: The genomic architecture of mouse tumor gene deletions suggests independent s…
View article: Supplementary Figure Legend from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression
Supplementary Figure Legend from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression Open
PDF - 106K, Contains the legends for Supplementary Figures 1-6 and Supplementary Tables 1-7.
View article: Magnetic resonance imaging–guided stereotactic laser ablation therapy for the treatment of pediatric epilepsy: a retrospective multiinstitutional study
Magnetic resonance imaging–guided stereotactic laser ablation therapy for the treatment of pediatric epilepsy: a retrospective multiinstitutional study Open
OBJECTIVE The authors of this study evaluated the safety and efficacy of stereotactic laser ablation (SLA) for the treatment of drug-resistant epilepsy (DRE) in children. METHODS Seventeen North American centers were enrolled in the study.…
View article: Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development
Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development Open
View article: A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan
A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan Open