Benjamin C. Shaw
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View article: Spatial protein profiling reveals active roles for astrocytes in the chronic active lesion core during multiple sclerosis
Spatial protein profiling reveals active roles for astrocytes in the chronic active lesion core during multiple sclerosis Open
View article: A novel PSMB8 isoform associated with multiple sclerosis lesions induces P-body formation
A novel PSMB8 isoform associated with multiple sclerosis lesions induces P-body formation Open
Introduction Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). Current therapies primarily target the inflammatory component of the disease and are highly effective in early stages of…
View article: A novel<i>PSMB8</i>isoform associated with multiple sclerosis lesions induces P-body formation
A novel<i>PSMB8</i>isoform associated with multiple sclerosis lesions induces P-body formation Open
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). Current therapies primarily target the inflammatory component of the disease and are highly effective in early stages of MS while lim…
View article: Immunity impacts cognitive deficits across neurological disorders
Immunity impacts cognitive deficits across neurological disorders Open
Cognitive deficits are a common comorbidity with neurological disorders and normal aging. Inflammation is associated with multiple diseases including classical neurodegenerative dementias such as Alzheimer's disease (AD) and autoimmune dis…
View article: Identification and Quantitation of Novel ABI3 Isoforms Relative to Alzheimer’s Disease Genetics and Neuropathology
Identification and Quantitation of Novel ABI3 Isoforms Relative to Alzheimer’s Disease Genetics and Neuropathology Open
Elucidating the actions of genetic polymorphisms associated with the risk of Alzheimer’s disease (AD) may provide novel insights into underlying mechanisms. Two polymorphisms have implicated ABI3 as a modulator of AD risk. Here, we sought …
View article: Targetability of the neurovascular unit in inflammatory diseases of the central nervous system
Targetability of the neurovascular unit in inflammatory diseases of the central nervous system Open
Summary The blood–brain barrier (BBB) is a selectively permeable barrier separating the periphery from the central nervous system (CNS). The BBB restricts the flow of most material into and out of the CNS, including many drugs that could b…
View article: Exogenous Short Chain Fatty Acid Effects in APP/PS1 Mice
Exogenous Short Chain Fatty Acid Effects in APP/PS1 Mice Open
Elucidating the impact of the gut microbiome on Alzheimer’s Disease (AD) is an area of intense interest. Short chain fatty acids (SCFAs) are major microbiota metabolites that have been implicated as a mediator of gut microbiome effects in …
View article: An Alternatively Spliced TREM2 Isoform Lacking the Ligand Binding Domain is Expressed in Human Brain
An Alternatively Spliced TREM2 Isoform Lacking the Ligand Binding Domain is Expressed in Human Brain Open
Background: Genetic variants in TREM2 are strongly associated with Alzheimer’s disease (AD) risk but alternative splicing in TREM2 transcripts has not been comprehensively described. Objective: Recognizing that alternative splice variants …
View article: An alternatively spliced TREM2 isoform lacking the ligand binding domain is expressed in human brain
An alternatively spliced TREM2 isoform lacking the ligand binding domain is expressed in human brain Open
Background Genetic variants in TREM2 are strongly associated with Alzheimer’s Disease (AD) risk but alternative splicing in TREM2 transcripts has not been comprehensively described. Objective Recognizing that alternative splice variants ca…
View article: Pseudogene-Mediated Gene Conversion After CRISPR-Cas9 Editing Demonstrated by Partial <i>CD33</i> Conversion with <i>SIGLEC22P</i>
Pseudogene-Mediated Gene Conversion After CRISPR-Cas9 Editing Demonstrated by Partial <i>CD33</i> Conversion with <i>SIGLEC22P</i> Open
Although gene editing workflows typically consider the possibility of off-target editing, pseudogene-directed homology repair has not, to our knowledge, been reported previously. Here, we employed a CRISPR-Cas9 strategy for targeted excisi…
View article: Medical views on the death by crucifixion of Jesus Christ
Medical views on the death by crucifixion of Jesus Christ Open
The death of Jesus Christ remains a pivotal moment in world history and a symbol of love, mercy, and courage across the globe. Yet for centuries, the manner of Jesus' death has remained a subject of controversy in academic and medical circ…
View article: Isolation and identification of leukocyte populations in intracranial blood collected during mechanical thrombectomy
Isolation and identification of leukocyte populations in intracranial blood collected during mechanical thrombectomy Open
Using standard techniques during mechanical thrombectomy, the Blood and Clot Thrombectomy Registry and Collaboration (BACTRAC) protocol (NCT03153683) isolates intracranial arterial blood distal to the thrombus and proximal systemic blood i…
View article: Analysis of Genetic Variants Associated with Levels of Immune Modulating Proteins for Impact on Alzheimer’s Disease Risk Reveal a Potential Role for SIGLEC14
Analysis of Genetic Variants Associated with Levels of Immune Modulating Proteins for Impact on Alzheimer’s Disease Risk Reveal a Potential Role for SIGLEC14 Open
Genome-wide association studies (GWAS) have identified immune-related genes as risk factors for Alzheimer’s disease (AD), including TREM2 and CD33, frequently passing a stringent false-discovery rate. These genes either encode or signal th…
View article: Pseudogene-mediated gene conversion after CRISPR-Cas9 editing demonstrated by partial<i>CD33</i>conversion with<i>SIGLEC22P</i>
Pseudogene-mediated gene conversion after CRISPR-Cas9 editing demonstrated by partial<i>CD33</i>conversion with<i>SIGLEC22P</i> Open
Although gene editing workflows typically consider the possibility of off-target editing, pseudogene-directed homology repair has not, to our knowledge, been reported previously. Here, we employed a CRISPR-Cas9 strategy for targeted excisi…
View article: History and Eschatology by N. T. Wright: A Review
History and Eschatology by N. T. Wright: A Review Open
Wright, N. T. History and Eschatology: Jesus and the Promise of Natural Theology. Waco, TX: Baylor University Press, 2019. 365 pp. $34.99
View article: Crucifixion in the Ancient World: A Historical Analysis
Crucifixion in the Ancient World: A Historical Analysis Open
Cook, John Granger. Crucifixion in the Mediterranean World. 2nd ed. Vol. 327. Wissenschaftliche Untersuchungen Zum Neuen Testament. Tübingen: Mohr Siebeck, 2019. Pp 549 pp. 79,00 €.
View article: ‘Cochlear-type’ hearing loss as part of aquaporin-4 neuromyelitis optica spectrum disorder
‘Cochlear-type’ hearing loss as part of aquaporin-4 neuromyelitis optica spectrum disorder Open
Neuromyelitis optica spectrum disorder is an inflammatory autoimmune central nervous system condition caused in the majority of cases by aquaporin-4 IgG antibodies. Aquaporin-4 is expressed in the cochlear and vestibular nuclei regions in …
View article: O-036 Changes in leukocyte distribution in intracranial vs. systemic blood collected during mechanical thrombectomy
O-036 Changes in leukocyte distribution in intracranial vs. systemic blood collected during mechanical thrombectomy Open
Introduction Since 2015, mechanical thrombectomy is the standard treatment for emergent large vessel occlusion stroke. Using standard techniques during mechanical thrombectomy, the Blood and Clot Thrombectomy Registry and Collaboration (BA…
View article: Philosophy of History, Historical Jesus Studies, and Miracles: Three Roadblocks to Resurrection Research
Philosophy of History, Historical Jesus Studies, and Miracles: Three Roadblocks to Resurrection Research Open
Jesus’ resurrection is considered by many to be a historical event, but objections are often raised regarding to such inquiry into the past. Philosophy of history is thus an important field in which various roadblocks to resurrection resea…
View article: Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the <i>MUC6</i> Gene, Near the <i>AP2A2</i> Gene
Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the <i>MUC6</i> Gene, Near the <i>AP2A2</i> Gene Open
We found evidence of late-onset Alzheimer disease (LOAD)-associated genetic polymorphism within an exon of Mucin 6 (MUC6) and immediately downstream from another gene: Adaptor Related Protein Complex 2 Subunit Alpha 2 (AP2A2). PCR analyses…
View article: P3‐149: CD33 MOLECULAR GENETICS IN ALZHEIMER'S DISEASE RISK
P3‐149: CD33 MOLECULAR GENETICS IN ALZHEIMER'S DISEASE RISK Open
Multiple genome-wide association studies (Hollingworth et al., 2011; Naj et al., 2011; Jansen et al., 2019) have implicated a CD33 polymorphism, rs3865444, as a genetic risk factor for Alzheimer's Disease (AD). Molecular studies have ident…
View article: (184) Fingolimod behaves as an agonist at sphingosine-1-phosphate receptor 1 to inhibit pain in an experimental autoimmune encephalomyelitis model of multiple sclerosis
(184) Fingolimod behaves as an agonist at sphingosine-1-phosphate receptor 1 to inhibit pain in an experimental autoimmune encephalomyelitis model of multiple sclerosis Open
View article: (183) Fingolimod Reduces Neuropathic Pain Behaviors in a Mouse Model of Multiple Sclerosis by a Sphingosine-1 Phosphate Receptor 1-Dependent Inhibition of Central Sensitization in the Dorsal Horn
(183) Fingolimod Reduces Neuropathic Pain Behaviors in a Mouse Model of Multiple Sclerosis by a Sphingosine-1 Phosphate Receptor 1-Dependent Inhibition of Central Sensitization in the Dorsal Horn Open