Benjamin Cathcart
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View article: Cardiomyocyte cytosolic nuclear self-DNA contributes to the pathogenesis of desmoplakin cardiomyopathy
Cardiomyocyte cytosolic nuclear self-DNA contributes to the pathogenesis of desmoplakin cardiomyopathy Open
Hereditary cardiomyopathies are the prototypic forms of heart failure and major causes of sudden cardiac death. The genome in cardiomyopathies is exposed to internal stressors, which damage the DNA and activate the DNA damage response (DDR…
View article: Genetic inactivation of β-catenin is salubrious, whereas its activation is deleterious in desmoplakin cardiomyopathy
Genetic inactivation of β-catenin is salubrious, whereas its activation is deleterious in desmoplakin cardiomyopathy Open
Aims Mutations in the DSP gene encoding desmoplakin, a constituent of the desmosomes at the intercalated discs (IDs), cause a phenotype that spans arrhythmogenic cardiomyopathy (ACM) and dilated cardiomyopathy. It is typically characterize…
View article: Cytosolic DNA sensing protein pathway is activated in human hearts with dilated cardiomyopathy
Cytosolic DNA sensing protein pathway is activated in human hearts with dilated cardiomyopathy Open
The genome is constantly exposed to numerous stressors that induce DNA lesions, including double-stranded DNA breaks (DSBs). DSBs are the most dangerous, as they induce genomic instability. In response to DNA damage, the cell activates nuc…
View article: Genetic Inactivation of β-Catenin Attenuates and Its Activation Aggravates Desmoplakin Cardiomyopathy
Genetic Inactivation of β-Catenin Attenuates and Its Activation Aggravates Desmoplakin Cardiomyopathy Open
Aim Mutations in the DSP gene encoding desmoplakin, a constituent of the desmosomes at the intercalated discs (IDs), cause a phenotype that spans arrhythmogenic cardiomyopathy (ACM) and dilated cardiomyopathy (DCM). It is typically charact…
View article: miR-96 and miR-183 differentially regulate neonatal and adult postinfarct neovascularization
miR-96 and miR-183 differentially regulate neonatal and adult postinfarct neovascularization Open
Following myocardial infarction (MI), the adult heart has minimal regenerative potential. Conversely, the neonatal heart can undergo extensive regeneration, and neovascularization capacity was hypothesized to contribute to this difference.…
View article: Role of ANLN in post ischaemic angiogenesis
Role of ANLN in post ischaemic angiogenesis Open
Angiogenesis is a key physiological process by which new blood vessels are dynamically
\nformed in Endothelial cell (EC) driven processes. The identification of new potential genes of
\ninterest in ECs can help to further understand the un…