Benjamin Cretin
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Functional Connectivity Changes Associated With Depression in Dementia With Lewy Bodies Open
Objectives Depressive symptoms are frequent in the early stages of dementia with Lewy bodies (DLB), and more than half of DLB patients would have a history of depression. Our study sought to investigate the functional connectivity (FC) cha…
Plasma biomarkers in dementia with Lewy bodies: evidence from memory clinic settings Open
Background Increasing evidence supports the use of plasma biomarkers of amyloid, tau, neurodegeneration and neuroinflammation for diagnosis of dementia. However, their performance for positive and differential diagnosis of dementia with Le…
Epileptic variant in the spectrum of Alzheimer's disease – practical implications Open
Alzheimer's disease (AD) is known to be associated with an increased risk of epilepsy, which is not exclusively related to the late stage of the disease - when a major cognitive impairment is observed, previously known as the dementia stag…
Association of Plasma Amyloid, P-Tau, GFAP, and NfL With CSF, Clinical, and Cognitive Features in Patients With Dementia With Lewy Bodies Open
Our study suggests a possible utility of plasma Aβ42/40, P-tau181, and P-tau231 as a noninvasive biomarkers to assess amyloid copathology in DLB, and plasma GFAP and NfL as monitoring biomarkers for cognitive symptoms in DLB.
Plasma biomarkers of amyloid, tau, axonal and neuroinflammation pathologies in dementia with Lewy bodies Open
BACKGROUND Increasing evidence supports the use of plasma biomarkers of amyloid, tau, neurodegeneration and neuroinflammation for diagnosis of dementia. However, their performance for positive and differential diagnosis of dementia with Le…
Diagnostic value of CSF chromogranin A to discriminate between Alzheimer's disease and dementia with Lewy bodies Open
Background Chromogranin A (CgA) seems to be involved in the pathophysiology of different neurodegenerative pathologies such as Alzheimer's disease (AD) and dementia with Lewy Bodies (DLB). CgA is present in the aggregates of amyloid plaque…
Plasma biomarkers of Alzheimer’s disease in dementia with Lewy bodies Open
Background Alzheimer’s disease (AD) co‐pathology is a common feature in dementia with Lewy bodies (DLB) and associated with a more rapid decline. Here, we aimed to evaluate plasma biomarkers as alternatives for CSF biomarkers for the detec…
Memory Outcome in Prodromal and Mild Dementia with Lewy Bodies and Alzheimer’s Disease: A Longitudinal Study Open
Background: Dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) are likely to induce memory impairments from the prodromal stage but, to our knowledge, no longitudinal study of these patients’ memory profile has been conducted to …
View article: Phenotype and imaging features associated with APP duplications
Phenotype and imaging features associated with APP duplications Open
Background APP duplication is a rare genetic cause of Alzheimer disease and cerebral amyloid angiopathy (CAA). We aimed to evaluate the phenotypes of APP duplications carriers. Methods Clinical, radiological, and neuropathological features…
Neural correlates of photophobia in prodromal and mild dementia with Lewy bodies Open
Background and objectives Photophobia is a sensory disturbance provoked by light. Little is known about the association between photophobia and dementia with Lewy bodies (DLB). In this study, we aimed to identify the frequency and the neur…
Involvement of ApoE4 in dementia with Lewy bodies in the prodromal and demented stages: evaluation of the Strasbourg cohort Open
Background: ApoE4 as a risk factor for AD is no longer a matter of debate. However, it is still an issue for dementia with Lewy bodies (DLB). We wanted to determine the involvement of ApoE4 according to different clinical parameters in our…
View article: Management of epilepsy in older adults: A critical review by the <scp>ILAE</scp> Task Force on Epilepsy in the elderly
Management of epilepsy in older adults: A critical review by the <span>ILAE</span> Task Force on Epilepsy in the elderly Open
Older adults represent a highly heterogeneous population, with multiple diverse subgroups. Therefore, an individualized approach to treatment is essential to meet the needs of each unique subgroup. Most comparative studies focusing on trea…
MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies Open
Background. Dementia with Lewy bodies (DLB) is a neurodegenerative disorder with a wide heterogeneity of symptoms, which suggests the existence of different subtypes. Objectives. We used data-driven analysis of MRI data to investigate DLB …
Sleep: The Tip of the Iceberg in the Bidirectional Link Between Alzheimer's Disease and Epilepsy Open
The observation that a pathophysiological link might exist between Alzheimer's disease (AD) and epilepsy dates back to the identification of the first cases of the pathology itself and is now strongly supported by an ever-increasing mounta…
Dementia with Lewy bodies subtypes identified by cluster analysis on structural MRI Open
Background Dementia with Lewy bodies (DLB) is a neurodegenerative disorder that presents with a variety of clinical symptoms. Part of the clinical heterogeneity within DLB has been related to the atrophy/sparing of the hippocampus. We exte…
Association of Plasma p-tau181 and p-tau231 Concentrations With Cognitive Decline in Patients With Probable Dementia With Lewy Bodies Open
This study suggests that plasma p-tau181 and p-tau231 levels may be used as cost-effective and accessible biomarkers to assess cognitive decline in individuals with DLB.
CSF in Epileptic Prodromal Alzheimer's Disease: No Diagnostic Contribution but a Pathophysiological One Open
Objective: To study whether cerebrospinal fluid (CSF) analysis may serve as a diagnostic test for the screening of epilepsy in sporadic prodromal Alzheimer's disease (AD). Methods: A total of 29 patients with epileptic prodromal sporadic A…
Association of cerebral microbleeds with cerebrospinal fluid Alzheimer‐biomarkers and clinical symptoms in early dementia with Lewy bodies Open
Objectives To determine the prevalence, localization and associations of cerebral microbleeds (CMB) in dementia with Lewy bodies (DLB) with its core clinical symptoms and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD). We…
View article: Dementia with Lewy bodies: Characteristics of the prodromal stage in a nationwide longitudinal cohort
Dementia with Lewy bodies: Characteristics of the prodromal stage in a nationwide longitudinal cohort Open
Background Little is known about the prodromal phase of Dementia with Lewy bodies (DLB). In a large prospective cohort of patients attending memory clinics presenting either subjective cognitive impairment (SCI) and mild neurocognitive imp…