Benjamin D. Auerbach
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View article: Altered auditory feature discrimination in a rat model of Fragile X Syndrome
Altered auditory feature discrimination in a rat model of Fragile X Syndrome Open
Atypical sensory processing, particularly in the auditory domain, is one of the most common and quality-of-life affecting symptoms seen in autism spectrum disorders (ASD). Fragile X Syndrome (FXS) is a leading inherited cause of ASD and a …
View article: Foxg1 gene mutation impairs auditory cortex response and reduces sound tolerance
Foxg1 gene mutation impairs auditory cortex response and reduces sound tolerance Open
FOXG1 syndrome (FS) is a rare and devastating neurodevelopmental disorder affected by FOXG1 gene mutations and reduced sound tolerance has been reported in children with FS. Effects of single missense mutation of Foxg1 gene on auditory fun…
View article: Altered auditory feature discrimination in a rat model of Fragile X Syndrome
Altered auditory feature discrimination in a rat model of Fragile X Syndrome Open
Atypical sensory processing, particularly in the auditory domain, is one of the most common and quality-of-life affecting symptoms seen in autism spectrum disorders (ASD). Fragile X Syndrome (FXS) is the leading inherited cause of ASD and …
View article: Evaluating the feasibility of prehospital point‐of‐care EEG: The prehospital implementation of rapid EEG (PHIRE) study
Evaluating the feasibility of prehospital point‐of‐care EEG: The prehospital implementation of rapid EEG (PHIRE) study Open
Among real-world prehospital encounters for patients with neurologic symptoms, point-of-care EEG was rapidly applied and yielded EEG recordings that could be used for clinical interpretation, demonstrating the feasibility of point-of-care …
View article: Editorial: Neural markers of sensory processing in development
Editorial: Neural markers of sensory processing in development Open
EDITORIAL article Front. Integr. Neurosci., 21 July 2023 Volume 17 - 2023 | https://doi.org/10.3389/fnint.2023.1256437
View article: Hearing in Complex Environments: Auditory Gain Control, Attention, and Hearing Loss
Hearing in Complex Environments: Auditory Gain Control, Attention, and Hearing Loss Open
Listening in noisy or complex sound environments is difficult for individuals with normal hearing and can be a debilitating impairment for those with hearing loss. Extracting meaningful information from a complex acoustic environment requi…
View article: Auditory hypersensitivity and processing deficits in a rat model of fragile X syndrome
Auditory hypersensitivity and processing deficits in a rat model of fragile X syndrome Open
Fragile X (FX) syndrome is one of the leading inherited causes of autism spectrum disorder (ASD). A majority of FX and ASD patients exhibit sensory hypersensitivity, including auditory hypersensitivity or hyperacusis, a condition in which …
View article: Auditory Hypersensitivity and Processing Deficits in a Rat Model of Fragile X Syndrome
Auditory Hypersensitivity and Processing Deficits in a Rat Model of Fragile X Syndrome Open
Fragile X (FX) syndrome is one of the leading inherited causes of autism spectrum disorder (ASD). A majority of FX and ASD patients exhibit sensory hypersensitivity, including auditory hypersensitivity or hyperacusis, a condition in which …
View article: Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence
Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence Open
Significance Achieving abstinence is difficult for individuals with cocaine use disorder but the greater challenge is avoiding relapse. Relapse vulnerability is provoked by exposure to drug-associated cues that evoke drug craving. Cue-indu…
View article: Mechanisms underlying auditory processing deficits in Fragile X syndrome
Mechanisms underlying auditory processing deficits in Fragile X syndrome Open
Autism spectrum disorders (ASD) are strongly associated with auditory hypersensitivity or hyperacusis (difficulty tolerating sounds). Fragile X syndrome (FXS), the most common monogenetic cause of ASD, has emerged as a powerful gateway for…
View article: Aberrant thalamocortical coherence in an animal model of tinnitus
Aberrant thalamocortical coherence in an animal model of tinnitus Open
Electrophysiological and imaging studies from humans suggest that the phantom sound of tinnitus is associated with abnormal thalamocortical neural oscillations (dysrhythmia) and enhanced gamma band activity in the auditory cortex. However,…
View article: Tinnitus and hyperacusis: Contributions of paraflocculus, reticular formation and stress
Tinnitus and hyperacusis: Contributions of paraflocculus, reticular formation and stress Open
Tinnitus and hyperacusis are common and potentially serious hearing disorders associated with noise-, age- or drug-induced hearing loss. Accumulating evidence suggests that tinnitus and hyperacusis are linked to excessive neural activity i…
View article: β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X
β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X Open
Synaptic protein synthesis is essential for modification of the brain by experience and is aberrant in several genetically defined disorders, notably fragile X (FX), a heritable cause of autism and intellectual disability. Neural activity …
View article: Inner Hair Cell Loss Disrupts Hearing and Cochlear Function Leading to Sensory Deprivation and Enhanced Central Auditory Gain
Inner Hair Cell Loss Disrupts Hearing and Cochlear Function Leading to Sensory Deprivation and Enhanced Central Auditory Gain Open
There are three times as many outer hair cells (OHC) as inner hair cells (IHC), yet IHC transmit virtually all acoustic information to the brain as they synapse with 90-95% of type I auditory nerve fibers. Here we review a comprehensive se…