Benjamin D. Fox
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View article: P.101 Miglustat: a first-in-class enzyme stabiliser for late-onset Pompe Disease
P.101 Miglustat: a first-in-class enzyme stabiliser for late-onset Pompe Disease Open
Background: Late-onset Pompe disease (LOPD) is caused by a deficiency of acid α-glucosidase (GAA), leading to progressive muscle and respiratory decline. Cipaglucosidase alfa (cipa), a recombinant human GAA naturally enriched with bis-mann…
View article: 1086 Evaluating a New Sleep Testing Device for Pediatric Patients: A Comparative Analysis of Type 2 HST vs In-lab PSG
1086 Evaluating a New Sleep Testing Device for Pediatric Patients: A Comparative Analysis of Type 2 HST vs In-lab PSG Open
Introduction High-quality sleep is critical for children’s and adolescents’ development and health. Despite the high prevalence of sleep disorders in this population, few polysomnography devices have tested specifically for pediatric use. …
View article: Optimizing Peripheral Nerve Block Placement in Hip Surgery: A Cadaveric Study Mapping the Posterior Cutaneous Innervation
Optimizing Peripheral Nerve Block Placement in Hip Surgery: A Cadaveric Study Mapping the Posterior Cutaneous Innervation Open
Optimizing analgesia after hip surgery enables more rapid recovery. However, peripheral nerve blocks (PNBs) often fail to provide adequate pain relief in the posterolateral hip as they typically target the lateral cutaneous nerve of the th…
View article: Validation of a novel mask-based device for monitoring of comprehensive sleep parameters and sleep disordered breathing
Validation of a novel mask-based device for monitoring of comprehensive sleep parameters and sleep disordered breathing Open
Purpose This study aimed to validate the new DormoTech Vlab device’s performance, usability, and validity as a sleep test and physiological data recorder. The novel device has been designed for patient comfort, ease of use, and home-based …
View article: 0317 Advancing Home Sleep Testing: A Comparative Analysis of Type 2 New HST Technology vs. In-Lab PSG Validation Study
0317 Advancing Home Sleep Testing: A Comparative Analysis of Type 2 New HST Technology vs. In-Lab PSG Validation Study Open
Introduction Currently, a typical home sleep test only measures respiratory signals, not actual sleep. Therefore, results may be inconclusive or false. Current practice also allows for one-night sleep study at home, that may also affect th…
View article: HPB P38 A Novel Ambulatory Pathway in the Management of Acute Pancreatitis
HPB P38 A Novel Ambulatory Pathway in the Management of Acute Pancreatitis Open
Background The incidence of acute pancreatitis has doubled over the last two decades, accounting for approximately 20,000 UK inpatient admissions yearly1. The Atlanta Classification defines three severity grades, with over 90% of patients …
View article: Transitioning from hospital to home with non-invasive ventilation: who benefits? Results of a cohort study
Transitioning from hospital to home with non-invasive ventilation: who benefits? Results of a cohort study Open
Background Non-invasive ventilation (NIV) is effective in a variety of acute respiratory illnesses in hospitalised patients. Home NIV is effective for stable patients with hypercapnia due to neuromuscular or chronic pulmonary disease. Howe…
View article: The Paradox of Pulmonary Vascular Resistance: Restoration of Pulmonary Capillary Recruitment as a Sine Qua Non for True Therapeutic Success in Pulmonary Arterial Hypertension
The Paradox of Pulmonary Vascular Resistance: Restoration of Pulmonary Capillary Recruitment as a Sine Qua Non for True Therapeutic Success in Pulmonary Arterial Hypertension Open
Exercise-induced increases in pulmonary blood flow normally increase pulmonary arterial pressure only minimally, largely due to a reserve of pulmonary capillaries that are available for recruitment to carry the flow. In pulmonary arterial …
View article: Pulmonary capillary recruitment and distention in mammalian lungs: species similarities
Pulmonary capillary recruitment and distention in mammalian lungs: species similarities Open
Pulmonary arterial pressure rises minimally during exercise. The pulmonary microcirculation accommodates increasing blood flow via recruitment of pulmonary capillaries and, at higher flows, by distention of already perfused capillaries. Th…
View article: Thoracentesis under clopidogrel is not associated with excessive bleeding events: a cohort study
Thoracentesis under clopidogrel is not associated with excessive bleeding events: a cohort study Open
Background Thoracentesis is a low-risk procedure for bleeding (approx. 2%). Data regarding safety of thoracentesis under treatment with clopidogrel is scarce, and current guidelines are not evidence based. We performed a retrospective stud…
View article: Non-tuberculous, adenosine deaminase-positive lymphocytic pleural effusion: Consider immunoglobulin G4-related disease.
Non-tuberculous, adenosine deaminase-positive lymphocytic pleural effusion: Consider immunoglobulin G4-related disease. Open
IgG4-RD may cause an ADA-positive, lymphocytic exudate with a high protein concentration, characteristics resembling tuberculous effusion. Thoracic lymphadenopathy, hyperglobulinemia, and an increased total IgG, IgG1, IgG4 may suggest the …
View article: Pulmonary capillary surface area in supine exercising humans: demonstration of vascular recruitment
Pulmonary capillary surface area in supine exercising humans: demonstration of vascular recruitment Open
In exercising humans, cardiac output (CO) increases, with minor increases in pulmonary artery pressure (PAP). It is unknown if the CO is accommodated via distention of already perfused capillaries or via recruitment of nonconcomitantly per…
View article: Step oximetry test: a validation study
Step oximetry test: a validation study Open
Introduction Step climbing is a potentially useful modality for testing exercise capacity. However, there are significant variations between test protocols and lack of consistent validation against gold standard cycle ergometry cardiopulmo…
View article: Tacrolimus Levels Are Not Associated with Risk of Malignancy in Lung Transplant Recipients
Tacrolimus Levels Are Not Associated with Risk of Malignancy in Lung Transplant Recipients Open
BACKGROUND Lung transplant (LTx) recipients suffer from high rates of malignancy. Exposure to immunosuppressive medication such as tacrolimus has been proposed as a risk factor for tumorigenesis. We hypothesized that chronically high level…
View article: The Prognostic Role of Ventilatory Inefficiency and Exercise Capacity in Idiopathic Pulmonary Fibrosis
The Prognostic Role of Ventilatory Inefficiency and Exercise Capacity in Idiopathic Pulmonary Fibrosis Open
This study provides simple, practical, and novel cut-off points for CPET as predictors of prognosis to identify high-risk IPF subjects. Impairment in exercise capacity and abnormal ventilatory responses during CPET were associated with poo…
View article: Pregnancy as a Possible Trigger for Heritable Pulmonary Arterial Hypertension
Pregnancy as a Possible Trigger for Heritable Pulmonary Arterial Hypertension Open
It is unclear whether pregnancy is a trigger or accelerant for idiopathic pulmonary arterial hypertension (PAH). Alternatively, its frequency close to the onset of symptoms and diagnosis in the idiopathic PAH population may represent a coi…
View article: The Diagnostic Value of the Pleural Fluid C-Reactive Protein in Parapneumonic Effusions
The Diagnostic Value of the Pleural Fluid C-Reactive Protein in Parapneumonic Effusions Open
Purpose . The aim of this study was to evaluate the sensitivity of pleural C-reactive protein (CRP) biomarker levels in identifying parapneumonic effusions. Methods . A single-center, retrospective review of 244 patients diagnosed with ple…