Benjamin D. Korman
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View article: The Function of <i>Efhd1</i> <sup>+</sup> Telocytes in the Synovial Lymphatic System and Inflammatory-Erosive Arthritis
The Function of <i>Efhd1</i> <sup>+</sup> Telocytes in the Synovial Lymphatic System and Inflammatory-Erosive Arthritis Open
Resting collecting lymphatic vessels (cLVs) sense edema in distal joints and initiate contractions via unknown mechanisms. Rheumatoid arthritis (RA) patients have lymphatic drainage deficiencies from affected joints, and defects in the syn…
View article: Pathologic Signaling and Disease Implications of Insulin-like Growth Factor Binding Proteins in Cancer, Cardiovascular Disease, and Fibrosis
Pathologic Signaling and Disease Implications of Insulin-like Growth Factor Binding Proteins in Cancer, Cardiovascular Disease, and Fibrosis Open
The insulin-like growth factor binding protein (IGFBP) family consists of seven members, which are known for their roles in regulating canonical insulin-like growth factor (IGF) signaling and, more recently, a variety of non-canonical sign…
View article: TNF drives aberrant BMP signaling to induce endothelial and mesenchymal dysregulation in pulmonary hypertension
TNF drives aberrant BMP signaling to induce endothelial and mesenchymal dysregulation in pulmonary hypertension Open
The pathobiology of pulmonary hypertension (PH) is complex and multiple cell types contribute to disease pathogenesis. We sought to characterize the molecular crosstalk between endothelial and mesenchymal cells that promote PH in the tumor…
View article: Systemic Sclerosis-Associated Pulmonary Arterial Hypertension: From Bedside to Bench and Back Again
Systemic Sclerosis-Associated Pulmonary Arterial Hypertension: From Bedside to Bench and Back Again Open
Systemic sclerosis (SSc) is a heterogeneous disease characterized by autoimmunity, vasculopathy, and fibrosis which affects the skin and internal organs. One key aspect of SSc vasculopathy is pulmonary arterial hypertension (SSc-PAH) which…
View article: Pericytes contribute to pulmonary vascular remodeling via HIF2α signaling
Pericytes contribute to pulmonary vascular remodeling via HIF2α signaling Open
View article: The cancer-associated glycan polysialic acid is dysregulated in systemic sclerosis and is associated with fibrosis
The cancer-associated glycan polysialic acid is dysregulated in systemic sclerosis and is associated with fibrosis Open
Polysia is more abundant in the skin and sera from patients with SSc and correlates with the degree of skin fibrosis. The aberrant expression of polySia highlights its potential use as a biomarker in patients with progressive forms of SSc.…
View article: Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis
Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis Open
Introduction Defective lymphatic drainage and translocation of B-cells in inflamed (Bin) joint-draining lymph node sinuses are pathogenic phenomena in patients with severe rheumatoid arthritis (RA). However, the molecular mechanisms underl…
View article: Implementation of automated behavior metrics to evaluate voluntary wheel running effects on inflammatory-erosive arthritis and interstitial lung disease in TNF-Tg mice
Implementation of automated behavior metrics to evaluate voluntary wheel running effects on inflammatory-erosive arthritis and interstitial lung disease in TNF-Tg mice Open
View article: Thy-1 plays a pathogenic role and is a potential biomarker for skin fibrosis in scleroderma
Thy-1 plays a pathogenic role and is a potential biomarker for skin fibrosis in scleroderma Open
Thy-1 (CD90) is a well-known marker of fibroblasts implicated in organ fibrosis, but its contribution to skin fibrosis remains unknown. We examined Thy-1 expression in scleroderma skin and its potential role as a biomarker and pathogenic f…
View article: Differences in symptom experience among patients with systemic sclerosis: a cluster analytic approach to identifying subgroups
Differences in symptom experience among patients with systemic sclerosis: a cluster analytic approach to identifying subgroups Open
Objectives Symptoms of people who have SSc are heterogeneous and difficult to address clinically. Because diverse symptoms often co-occur and may share common underlying mechanisms, identifying symptoms that cluster together may better tar…
View article: Clinical and Autoantibody Associations in Antinuclear Antibody–Positive Systemic Sclerosis Lacking Prototypic Autoantibodies
Clinical and Autoantibody Associations in Antinuclear Antibody–Positive Systemic Sclerosis Lacking Prototypic Autoantibodies Open
BACKGROUND/OBJECTIVES: The subset of ANA-positive patients with systemic sclerosis (SSc) who lack prototypic SSc-specific autoantibodies (centromere, topoisomerase, RNA polymerase III, “triple negative SSc”) is poorly characterized. We ass…
View article: Alterations of the Primary Cilia Gene <i>SPAG17</i> and <i>SOX9</i> Locus Noncoding RNAs Identified by RNA‐Sequencing Analysis in Patients With Systemic Sclerosis
Alterations of the Primary Cilia Gene <i>SPAG17</i> and <i>SOX9</i> Locus Noncoding RNAs Identified by RNA‐Sequencing Analysis in Patients With Systemic Sclerosis Open
Objective Systemic sclerosis (SSc) is characterized by immune activation, vasculopathy, and unresolving fibrosis in the skin, lungs, and other organs. We performed RNA‐sequencing analysis on skin biopsy samples and peripheral blood mononuc…
View article: RNA-Seq analysis identifies novel roles for the primary cilia gene <i>SPAG17</i> and the <i>SOX9</i> locus non-coding RNAs in systemic sclerosis
RNA-Seq analysis identifies novel roles for the primary cilia gene <i>SPAG17</i> and the <i>SOX9</i> locus non-coding RNAs in systemic sclerosis Open
Systemic sclerosis ( SSc ) is characterized by immune activation, vasculopathy, and unresolving fibrosis in the skin, lungs, and other organs. We performed RNA-Seq analysis on skin biopsies and peripheral blood mononuclear cells ( PBMCs ) …
View article: Circulating CTRP9 Is Associated With Severity of Systemic Sclerosis–Associated Interstitial Lung Disease
Circulating CTRP9 Is Associated With Severity of Systemic Sclerosis–Associated Interstitial Lung Disease Open
Objective While interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc), there remains a paucity of predictive markers to assess disease progression. We previously demonstrated that adipo…
View article: Engineering Advanced In Vitro Models of Systemic Sclerosis for Drug Discovery and Development
Engineering Advanced In Vitro Models of Systemic Sclerosis for Drug Discovery and Development Open
Systemic sclerosis (SSc) is a complex multisystem disease with the highest case‐specific mortality among all autoimmune rheumatic diseases, yet without any available curative therapy. Therefore, the development of novel therapeutic antifib…
View article: Targeting CD38-dependent NAD+ metabolism to mitigate multiple organ fibrosis
Targeting CD38-dependent NAD+ metabolism to mitigate multiple organ fibrosis Open
View article: Adipocytic Progenitor Cells Give Rise to Pathogenic Myofibroblasts: Adipocyte-to-Mesenchymal Transition and Its Emerging Role in Fibrosis in Multiple Organs
Adipocytic Progenitor Cells Give Rise to Pathogenic Myofibroblasts: Adipocyte-to-Mesenchymal Transition and Its Emerging Role in Fibrosis in Multiple Organs Open
View article: Tumor Necrosis Factor Induces Obliterative Pulmonary Vascular Disease in a Novel Model of Connective Tissue Disease–Associated Pulmonary Arterial Hypertension
Tumor Necrosis Factor Induces Obliterative Pulmonary Vascular Disease in a Novel Model of Connective Tissue Disease–Associated Pulmonary Arterial Hypertension Open
Objective Connective tissue disease ( CTD )–associated pulmonary arterial hypertension ( PAH ) is the second most common etiology of PAH and carries a poor prognosis. Recently, it has been shown that female human tumor necrosis factor ( TN…
View article: Targeting CD38-Dependent NAD+ Metabolism to Mitigate Multiple Organ Fibrosis
Targeting CD38-Dependent NAD+ Metabolism to Mitigate Multiple Organ Fibrosis Open
View article: <i>HLA</i>and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry
<i>HLA</i>and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry Open
Significance HLA alleles have previously been implicated with scleroderma risk, but, in this study, using a European American ancestral cohort and a newly recruited large cohort of African Americans, we comprehensively define the HLA allel…
View article: A case of concurrent systemic sclerosis and scleredema
A case of concurrent systemic sclerosis and scleredema Open
Scleroderma and scleroderma mimics belong to a heterogenous group of sclerosing skin diseases that share the clinical features of skin hardening and thickening with or without adherence to underlying fascia.1 These diseases are distinguish…
View article: 700 Targeting SIRT/CD38/NAD+ homeostasis to mitigate fibrosis in scleroderma
700 Targeting SIRT/CD38/NAD+ homeostasis to mitigate fibrosis in scleroderma Open
View article: Evolving insights into the cellular and molecular pathogenesis of fibrosis in systemic sclerosis
Evolving insights into the cellular and molecular pathogenesis of fibrosis in systemic sclerosis Open
View article: The novel adipokine C1q-TNF related protein 9 (CTRP9) is elevated in systemic sclerosis-associated interstitial lung disease.
The novel adipokine C1q-TNF related protein 9 (CTRP9) is elevated in systemic sclerosis-associated interstitial lung disease. Open
View article: Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis
Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis Open
View article: Brief Report: Whole‐Exome Sequencing to Identify Rare Variants and Gene Networks That Increase Susceptibility to Scleroderma in African Americans
Brief Report: Whole‐Exome Sequencing to Identify Rare Variants and Gene Networks That Increase Susceptibility to Scleroderma in African Americans Open
Objective Whole‐exome sequencing ( WES ) studies in systemic sclerosis ( SS c) patients of European American ( EA ) ancestry have identified variants in the ATP 8B4 gene and enrichment of variants in genes in the extracellular matrix ( ECM…
View article: The Scleroderma Patient-Centered Intervention Network Cohort: baseline clinical features and comparison with other large scleroderma cohorts
The Scleroderma Patient-Centered Intervention Network Cohort: baseline clinical features and comparison with other large scleroderma cohorts Open
Although there are some differences, the SPIN Cohort is broadly comparable with other large prevalent SSc cohorts, increasing confidence that insights gained from the SPIN Cohort should be generalizable, although it should be noted that al…
View article: Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target
Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target Open
Skin fibrosis in systemic sclerosis (SSc) is accompanied by attrition of dermal white adipose tissue (dWAT) and reduced levels of circulating adiponectin. Since adiponectin has potent regulatory effects on fibroblasts, we sought to assess …
View article: Brief Report: Association of Elevated Adipsin Levels With Pulmonary Arterial Hypertension in Systemic Sclerosis
Brief Report: Association of Elevated Adipsin Levels With Pulmonary Arterial Hypertension in Systemic Sclerosis Open
Objective Adipose tissues secrete adipokines, peptides with potent effects modulating fibrosis, inflammation, and vascular homeostasis. Dysregulated adipose tissue biology and adipokine balance have recently been implicated in systemic scl…
View article: Validation of the Body Concealment Scale for Scleroderma (BCSS): Replication in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort
Validation of the Body Concealment Scale for Scleroderma (BCSS): Replication in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort Open