Benjamin D. Smith
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View article: Comparing Survival Differences between Patients Undergoing Breast-Conserving Therapy Versus Total Mastectomy as a First Treatment for Early Stage Breast Cancer
Comparing Survival Differences between Patients Undergoing Breast-Conserving Therapy Versus Total Mastectomy as a First Treatment for Early Stage Breast Cancer Open
View article: Ivosidenib or venetoclax combined with hypomethylating agents in IDH1-mutated acute myeloid leukemia: a real-world study
Ivosidenib or venetoclax combined with hypomethylating agents in IDH1-mutated acute myeloid leukemia: a real-world study Open
Approximately 10% of patients with newly diagnosed acute myeloid leukemia (ND-AML) harbor the isocitrate dehydrogenase 1 gene mutation (mIDH1). In this real-world study evaluating ivosidenib (IVO) + hypomethylating agents (HMAs; n =…
View article: Short-chain per- and polyfluoroalkyl substances associate with elevated alanine aminotransferase: Cross-sectional analysis results from the STRIVE cohort
Short-chain per- and polyfluoroalkyl substances associate with elevated alanine aminotransferase: Cross-sectional analysis results from the STRIVE cohort Open
View article: Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer
Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer for which there is a critical need to identify novel therapeutic targets. Herein we define PSGL-1 as a checkpoint inhibitor using a syngeneic orthotopic model of PDAC. As with PDAC…
View article: The impact of breast radiotherapy on the tumor genome and immune ecosystem
The impact of breast radiotherapy on the tumor genome and immune ecosystem Open
Radiotherapy is a pillar of breast cancer treatment; however, it remains unclear how radiotherapy modulates the tumor microenvironment. We investigated this question in a cohort of 20 patients with estrogen-receptor positive (ER+
View article: P173: Phase 2 trial of ablative radiotherapy and endocrine therapy for invasive breast cancer without surgery: patient reported outcomes
P173: Phase 2 trial of ablative radiotherapy and endocrine therapy for invasive breast cancer without surgery: patient reported outcomes Open
View article: Cardiovascular Disease and Breast Cancer Stage at Diagnosis
Cardiovascular Disease and Breast Cancer Stage at Diagnosis Open
Importance Cardiovascular disease (CVD) and cancer are the leading causes of mortality in the US. Large-scale population-based and mechanistic studies support a direct effect of CVD on accelerated tumor growth and spread, specifically in b…
View article: Creating a Cooperative AI Policymaking Platform through Open Source Collaboration
Creating a Cooperative AI Policymaking Platform through Open Source Collaboration Open
Advances in artificial intelligence (AI) present significant risks and opportunities, requiring improved governance to mitigate societal harms and promote equitable benefits. Current incentive structures and regulatory delays may hinder re…
View article: Outcomes After Palliative Radiation Therapy in Patients With Symptomatic Locoregionally Advanced Breast Cancer
Outcomes After Palliative Radiation Therapy in Patients With Symptomatic Locoregionally Advanced Breast Cancer Open
View article: Stability of Mg IG/GSH combo injection
Stability of Mg IG/GSH combo injection Open
Objective: To investigate the stability of magnesium isoglycyrrhizinate (Mg IG) injection solution when mixed with reduced glutathione (GSH) injection solution at room temperature. Method: High-performance liquid chromatography was used to…
View article: Financial toxicity in breast cancer patients receiving regional nodal irradiation: Variation by cancer subtype
Financial toxicity in breast cancer patients receiving regional nodal irradiation: Variation by cancer subtype Open
Among patients with breast cancer receiving RNI, triple negative subtype was associated with severe FT, suggesting that tumor receptor subtype may help identify a key breast cancer subpopulation for early FT intervention.
View article: Residual Nodal Burden After Neoadjuvant Chemotherapy in cN1 Breast Cancer Patients with Positive Nodes at Targeted Axillary Dissection
Residual Nodal Burden After Neoadjuvant Chemotherapy in cN1 Breast Cancer Patients with Positive Nodes at Targeted Axillary Dissection Open
View article: Clinical Outcomes for <i>BRCA</i> Pathogenic Variant Carriers With Breast Cancer Undergoing Breast Conservation
Clinical Outcomes for <i>BRCA</i> Pathogenic Variant Carriers With Breast Cancer Undergoing Breast Conservation Open
Importance Although most women with BRCA- associated breast cancer choose bilateral mastectomy, current guidelines support breast-conserving therapy as an option. As the indications for genetic testing expand and targeted therapies emerge,…
View article: The Importance of Digital Rectal Examination in Identifying Early-Onset Rectal Malignancies
The Importance of Digital Rectal Examination in Identifying Early-Onset Rectal Malignancies Open
Colorectal cancer (CRC) is the second most diagnosed cancer and the second leading cause of cancer-related deaths in the United States. Rectal cancers, specifically, are the second most common cancer of the large intestine. Although once p…
View article: Premastectomy Radiotherapy and Immediate Breast Reconstruction
Premastectomy Radiotherapy and Immediate Breast Reconstruction Open
Importance Premastectomy radiotherapy (PreMRT) is a new treatment sequence to avoid the adverse effects of radiotherapy on the final breast reconstruction while achieving the benefits of immediate breast reconstruction (IMBR). Objective To…
View article: Polyamorous Scheduling
Polyamorous Scheduling Open
Finding schedules for pairwise meetings between the members of a complex social group without creating interpersonal conflict is challenging, especially when different relationships have different needs. We formally define and study the un…
View article: The Anatomy of Labor Cost Adjustment to Demand Shocks: Germany and Italy During the Great Recession
The Anatomy of Labor Cost Adjustment to Demand Shocks: Germany and Italy During the Great Recession Open
View article: Financial Toxicity in Breast Cancer Patients Receiving Regional Nodal Irradiation: Variation by Cancer Subtype
Financial Toxicity in Breast Cancer Patients Receiving Regional Nodal Irradiation: Variation by Cancer Subtype Open
View article: Association Between Symptom Burden and Early Lymphatic Abnormalities After Regional Nodal Irradiation for Breast Cancer
Association Between Symptom Burden and Early Lymphatic Abnormalities After Regional Nodal Irradiation for Breast Cancer Open
View article: Patient Interest in Exploring Nonsurgical Treatment Approaches for Early-Stage Breast Cancer: A Qualitative Study
Patient Interest in Exploring Nonsurgical Treatment Approaches for Early-Stage Breast Cancer: A Qualitative Study Open
View article: 243MO Omission of breast surgery after neoadjuvant systemic therapy for invasive cancer: Three-year preplanned primary-endpoint on a phase II multicentre prospective trial
243MO Omission of breast surgery after neoadjuvant systemic therapy for invasive cancer: Three-year preplanned primary-endpoint on a phase II multicentre prospective trial Open
View article: Addition of Metastasis-Directed Therapy to Standard of Care Systemic Therapy for Oligometastatic Breast Cancer (EXTEND): A Multicenter, Randomized Phase II Trial
Addition of Metastasis-Directed Therapy to Standard of Care Systemic Therapy for Oligometastatic Breast Cancer (EXTEND): A Multicenter, Randomized Phase II Trial Open
View article: Patient-Reported Outcomes of Omission of Breast Surgery Following Neoadjuvant Systemic Therapy
Patient-Reported Outcomes of Omission of Breast Surgery Following Neoadjuvant Systemic Therapy Open
Importance Patients should have an active role in decisions about pursuing or forgoing specific therapies in treatment de-escalation trials. Objective To evaluate longitudinal patient-reported outcomes (PROs) encompassing decisional comfor…
View article: Automated contouring and statistical process control for plan quality in a breast clinical trial
Automated contouring and statistical process control for plan quality in a breast clinical trial Open
An automated contouring model in a statistical process control framework was appropriate for assessing planning consistency in a breast radiotherapy clinical trial.
View article: PB1966: THE EFFECT OF BODY MASS INDEX ON THE SAFETY OF BOSUTINIB IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA: A POST HOC POOLED DATA ANALYSIS
PB1966: THE EFFECT OF BODY MASS INDEX ON THE SAFETY OF BOSUTINIB IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA: A POST HOC POOLED DATA ANALYSIS Open
Topic: 8. Chronic myeloid leukemia - Clinical Background: Bosutinib is approved for the treatment of Philadelphia chromosome–positive (Ph+) chronic myeloid leukemia (CML) resistant/intolerant to prior therapy and newly diagnosed Ph+ chroni…
View article: Household Mobility, Networks, and Gentrification of Minority Neighborhoods in the US
Household Mobility, Networks, and Gentrification of Minority Neighborhoods in the US Open
We study how recent gentrification shocks impact Black and Hispanic neighborhoods, including where minority households move to after a shock and if the subsequent spatial distribution of households within a labor market area affects segreg…
View article: Long-term Patient-Reported Outcomes in a Population-Based Cohort Following Radiotherapy vs Surgery for Oropharyngeal Cancer
Long-term Patient-Reported Outcomes in a Population-Based Cohort Following Radiotherapy vs Surgery for Oropharyngeal Cancer Open
Importance Oncologic outcomes are similar for patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with primary surgery or radiotherapy. However, comparative differences in long-term patient-reported outcomes (PROs) between …
View article: Patient-reported Quality of Life After Breast-conserving Surgery With Radiotherapy Versus Mastectomy and Reconstruction
Patient-reported Quality of Life After Breast-conserving Surgery With Radiotherapy Versus Mastectomy and Reconstruction Open
Objective: To compare long-term quality of life (QOL) outcomes in breast cancer survivors who received breast-conserving surgery with radiotherapy (BCS+RT) with those who received a mastectomy and reconstructive surgery (Mast+Recon) withou…
View article: Evaluation of the ESMO-Magnitude of Clinical Benefit Scale version 1.1 (ESMO-MCBS v1.1) for adjuvant radiotherapy in breast cancer
Evaluation of the ESMO-Magnitude of Clinical Benefit Scale version 1.1 (ESMO-MCBS v1.1) for adjuvant radiotherapy in breast cancer Open
This study represents a first step in determining the utility of the ESMO-MCBS in the evaluation of clinical benefit in radiotherapy. Important shortcomings were identified that would need to be addressed in developing a version of the ESM…
View article: ANCA vasculitis expands the spectrum of autoimmune manifestations of activated PI3 kinase δ syndrome
ANCA vasculitis expands the spectrum of autoimmune manifestations of activated PI3 kinase δ syndrome Open
Activated phosphoinositide 3-kinase δ syndrome (APDS) is a combined immunodeficiency with a broad clinical phenotype, including not only an increased propensity for sinopulmonary and herpesviruses infections but also immune dysregulation, …