Benjamin Delwarde
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View article: Integrated clustering of multiple immune marker trajectories reveals different immunotypes in severely injured patients
Integrated clustering of multiple immune marker trajectories reveals different immunotypes in severely injured patients Open
Background The immune response of critically ill patients, such as those with sepsis, severe trauma, or major surgery, is heterogeneous and dynamic, but its characterization and impact on outcomes are poorly understood. Until now, the prim…
View article: Persistently Elevated Soluble Triggering Receptor Expressed on Myeloid Cells 1 and Decreased Monocyte Human Leucocyte Antigen DR Expression Are Associated With Nosocomial Infections in Septic Shock Patients
Persistently Elevated Soluble Triggering Receptor Expressed on Myeloid Cells 1 and Decreased Monocyte Human Leucocyte Antigen DR Expression Are Associated With Nosocomial Infections in Septic Shock Patients Open
OBJECTIVES: Sepsis-acquired immunosuppression may play a major role in patients’ prognosis through increased risk of secondary infections. Triggering receptor expressed on myeloid cells 1 (TREM-1) is an innate immune receptor involved in c…
View article: A stratification strategy to predict secondary infection in critical illness-induced immune dysfunction: the REALIST score
A stratification strategy to predict secondary infection in critical illness-induced immune dysfunction: the REALIST score Open
Background Although multiple individual immune parameters have been demonstrated to predict the occurrence of secondary infection after critical illness, significant questions remain with regards to the selection, timing and clinical utili…
View article: Immune profiling demonstrates a common immune signature of delayed acquired immunodeficiency in patients with various etiologies of severe injury
Immune profiling demonstrates a common immune signature of delayed acquired immunodeficiency in patients with various etiologies of severe injury Open
Background and Research Question The host response plays a central role in the pathophysiology of sepsis and severe injuries. So far, no study has comprehensively described the overtime changes of the injury-induced immune profile in a lar…
View article: Deciphering heterogeneity of septic shock patients using immune functional assays: a proof of concept study
Deciphering heterogeneity of septic shock patients using immune functional assays: a proof of concept study Open
The complexity of sepsis pathophysiology hinders patient management and therapeutic decisions. In this proof-of-concept study we characterised the underlying host immune response alterations using a standardised immune functional assay (IF…
View article: Source of Circulating Pentraxin 3 in Septic Shock Patients
Source of Circulating Pentraxin 3 in Septic Shock Patients Open
Sepsis, which is the leading cause of death in intensive care units (ICU), has been acknowledged as a global health priority by the WHO in 2017. Identification of biomarkers allowing early stratification and recognition of patients at high…
View article: Low Interleukin-7 Receptor Messenger RNA Expression Is Independently Associated With Day 28 Mortality in Septic Shock Patients*
Low Interleukin-7 Receptor Messenger RNA Expression Is Independently Associated With Day 28 Mortality in Septic Shock Patients* Open
Objectives: Septic shock is the primary cause of death in ICUs. A better comprehension of its pathophysiology, in particular, the immune alteration mechanisms, opened new therapeutic perspectives such as the recombinant interleukin-7. The …