Benjamin Doyle
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View article: Nociceptor neurons affect cancer immunosurveillance
Nociceptor neurons affect cancer immunosurveillance Open
Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory peripheral nervous systems 1–5 . Whether the neo-innervation of tumours by pain-initiating sensory neurons affects cancer immunosurveillance remains unc…
View article: Nociceptor neurons promote IgE class switch in B cells
Nociceptor neurons promote IgE class switch in B cells Open
Nociceptors, the high-threshold primary sensory neurons that trigger pain, interact with immune cells in the periphery to modulate innate immune responses. Whether they also participate in adaptive and humoral immunity is, however, not kno…
View article: Nociceptor neurons impair cancer immunosurveillance
Nociceptor neurons impair cancer immunosurveillance Open
Solid tumors are innervated by nerve fibers that arise from the autonomic and sensory peripheral nervous systems. In prostate cancer, doublecortin-expressing neural progenitors initiate autonomic adrenergic neurogenesis1 which facilitates …
View article: Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker
Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker Open
Background and Purpose Many pain‐triggering nociceptor neurons express TRPV1 or TRPA1, cation‐selective channels with large pores that enable permeation of QX‐314, a cationic analogue of lidocaine. Co‐application of QX‐314 with TRPV1 or TR…
View article: Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker
Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker Open
Background and Purpose: Many pain-triggering nociceptor neurons express TRPV1 or TRPA1, cation-selective channels with large pores that enable permeation of QX-314, a cationic analogue of lidocaine. Co-application of QX-314 with TRPV1 or T…
View article: Inhibiting cough by silencing large pore-expressing airway sensory neurons with a charged sodium channel blocker
Inhibiting cough by silencing large pore-expressing airway sensory neurons with a charged sodium channel blocker Open
Although multiple diseases of the respiratory system cause cough, there are few effective treatments for this common condition. We previously developed a strategy to treat pain and itch via the long-lasting inhibition of nociceptor sensory…
View article: IL-33–Stimulated Murine Mast Cells Polarize Alternatively Activated Macrophages, Which Suppress T Cells That Mediate Experimental Autoimmune Encephalomyelitis
IL-33–Stimulated Murine Mast Cells Polarize Alternatively Activated Macrophages, Which Suppress T Cells That Mediate Experimental Autoimmune Encephalomyelitis Open
IL-33 is known to promote type 2 immune responses through ST2, a component of the IL-33R complex, expressed primarily on mast cells, Th2 cells, group 2 innate lymphoid cells and regulatory T cells, and to a lesser extent, on NK cells and T…
View article: Unravelling the transcriptional responses of TGF‐β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification
Unravelling the transcriptional responses of TGF‐β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification Open
Cell differentiation is directed by extracellular cues and intrinsic epigenetic modifications, which control chromatin organization and transcriptional activation. Central to this process is PRC2, which modulates the di‐ and trimethylation…
View article: Epigenetic Factors in Schizophrenia: Mechanisms and Experimental Approaches
Epigenetic Factors in Schizophrenia: Mechanisms and Experimental Approaches Open
Schizophrenia is a chronic mental disorder that is still poorly understood despite decades of study. Many factors have been found to contribute to the pathogenesis, including neurodevelopmental disturbance, genetic risk, and environmental …
View article: Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells
Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells Open
Polycomb proteins assemble to form complexes with important roles in epigenetic regulation. The Polycomb Repressive Complex 2 (PRC2) modulates the di- and tri-methylation of lysine 27 on histone H3, each of which are associated with gene r…