Benjamin E. Deverman
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View article: Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling
Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling Open
View article: Cell-surface proteomic profiling identifies CD72 as a regulator of microglial tiling
Cell-surface proteomic profiling identifies CD72 as a regulator of microglial tiling Open
SUMMARY Microglial tiling—the phenomenon of consistent cell-to-cell distances and non-overlapping processes—is regarded as a qualitative indicator of homeostasis, but mechanisms of microglial tiling are unknown. We used cell-surface proxim…
View article: Author Correction: In vivo base editing extends lifespan of a humanized mouse model of prion disease
Author Correction: In vivo base editing extends lifespan of a humanized mouse model of prion disease Open
View article: In vivo base editing extends lifespan of a humanized mouse model of prion disease
In vivo base editing extends lifespan of a humanized mouse model of prion disease Open
Prion disease is a fatal neurodegenerative disease caused by the misfolding of prion protein (PrP) encoded by the PRNP gene. While there is currently no cure for the disease, depleting PrP in the brain is an established strategy to prevent…
View article: Systematic multi-trait AAV capsid engineering for efficient gene delivery
Systematic multi-trait AAV capsid engineering for efficient gene delivery Open
View article: Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor Open
Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid-onset dementia and death. However, elimination of endogenous PrP halts prion disease progression. In this stu…
View article: An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery
An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery Open
Developing vehicles that efficiently deliver genes throughout the human central nervous system (CNS) will broaden the range of treatable genetic diseases. We engineered an AAV capsid, BI-hTFR1, that binds human Transferrin Receptor (TfR1),…
View article: Publisher Correction: Spatial atlas of the mouse central nervous system at molecular resolution
Publisher Correction: Spatial atlas of the mouse central nervous system at molecular resolution Open
View article: Removal of a partial genomic duplication restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer
Removal of a partial genomic duplication restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer Open
View article: A marmoset brain cell census reveals regional specialization of cellular identities
A marmoset brain cell census reveals regional specialization of cellular identities Open
The mammalian brain is composed of many brain structures, each with its own ontogenetic and developmental history. We used single-nucleus RNA sequencing to sample over 2.4 million brain cells across 18 locations in the common marmoset, a N…
View article: Systematic Multi-Trait AAV Capsid Engineering for Efficient Gene Delivery
Systematic Multi-Trait AAV Capsid Engineering for Efficient Gene Delivery Open
Datasets for "Systematic Multi-Trait AAV Capsid Engineering for Efficient Gene Delivery", Eid et al., Nature Communications.
View article: Systematic Multi-Trait AAV Capsid Engineering for Efficient Gene Delivery
Systematic Multi-Trait AAV Capsid Engineering for Efficient Gene Delivery Open
Datasets for "Systematic Multi-Trait AAV Capsid Engineering for Efficient Gene Delivery", Eid et al., Nature Communications.
View article: Spatial atlas of the mouse central nervous system at molecular resolution
Spatial atlas of the mouse central nervous system at molecular resolution Open
Spatially charting molecular cell types at single-cell resolution across the 3D volume is critical for illustrating the molecular basis of brain anatomy and functions. Single-cell RNA sequencing has profiled molecular cell types in the mou…
View article: Next-generation sequencing of AAV.CAP-Mac from Chuapoco et al. (2023) Nature Nanotechnology
Next-generation sequencing of AAV.CAP-Mac from Chuapoco et al. (2023) Nature Nanotechnology Open
Dataset of next-generation sequencing of enrichment of AAV.CAP-Mac in various tissues from the publication: Chuapoco, M.R., Flytzanis, N.C., Goeden, N. et al. Adeno-associated viral vectors for functional intravenous gene transfer…
View article: Next-generation sequencing of AAV.CAP-Mac from Chuapoco et al. (2023) Nature Nanotechnology
Next-generation sequencing of AAV.CAP-Mac from Chuapoco et al. (2023) Nature Nanotechnology Open
Dataset of next-generation sequencing of enrichment of AAV.CAP-Mac in various tissues from the publication: Chuapoco, M.R., Flytzanis, N.C., Goeden, N. et al. Adeno-associated viral vectors for functional intravenous gene transfer…
View article: TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice
TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice Open
View article: Targeting AAV vectors to the central nervous system by engineering capsid–receptor interactions that enable crossing of the blood–brain barrier
Targeting AAV vectors to the central nervous system by engineering capsid–receptor interactions that enable crossing of the blood–brain barrier Open
Viruses have evolved the ability to bind and enter cells through interactions with a wide variety of cell macromolecules. We engineered peptide-modified adeno-associated virus (AAV) capsids that transduce the brain through the introduction…
View article: Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain
Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain Open
View article: Removal of a genomic duplication by double-nicking CRISPR restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer
Removal of a genomic duplication by double-nicking CRISPR restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer Open
Copy number variations, and particularly duplications of genomic regions, have been strongly associated with various neurodegenerative conditions including autism spectrum disorder (ASD). These genetic variations have been found to have a …
View article: Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions
Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions Open
Dataset for "Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions."
View article: Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions
Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions Open
Dataset for "Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions."
View article: Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions
Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions Open
Dataset for "Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions."
View article: Intravenous functional gene transfer throughout the brain of non-human primates using AAV
Intravenous functional gene transfer throughout the brain of non-human primates using AAV Open
Adeno-associated viruses (AAVs) promise robust gene delivery to the brain through non-invasive, intravenous delivery. However, unlike in rodents, few neurotropic AAVs efficiently cross the blood-brain barrier in non-human primates (NHPs). …
View article: Systematic multi-trait AAV capsid engineering for efficient gene delivery
Systematic multi-trait AAV capsid engineering for efficient gene delivery Open
Broadening gene therapy applications requires manufacturable vectors that efficiently transduce target cells in humans and preclinical models. Conventional selections of adeno-associated virus (AAV) capsid libraries are inefficient at sear…
View article: Targeting AAV vectors to the CNS via<i>de novo</i>engineered capsid-receptor interactions
Targeting AAV vectors to the CNS via<i>de novo</i>engineered capsid-receptor interactions Open
Viruses have evolved the ability to bind and enter cells through interactions with a wide variety of host cell macromolecules. Here, we screened for AAV capsids that bind two host cell proteins expressed on the mouse blood-brain barrier, L…
View article: A marmoset brain cell census reveals influence of developmental origin and functional class on neuronal identity
A marmoset brain cell census reveals influence of developmental origin and functional class on neuronal identity Open
The mammalian brain is composed of many brain structures, each with its own ontogenetic and developmental history. Transcriptionally-based cell type taxonomies reveal cell type composition and similarity relationships within and across bra…
View article: A high-efficiency AAV for endothelial cell transduction throughout the central nervous system
A high-efficiency AAV for endothelial cell transduction throughout the central nervous system Open
View article: Intravenous gene transfer throughout the brain of infant Old World primates using AAV
Intravenous gene transfer throughout the brain of infant Old World primates using AAV Open
Adeno-associated viruses (AAVs) can enable robust and safe gene delivery to the mammalian central nervous system (CNS). While the scientific community has developed numerous neurotropic AAV variants for systemic gene-transfer to the rodent…
View article: Improved systemic AAV gene therapy with a neurotrophic capsid in Niemann–Pick disease type C1 mice
Improved systemic AAV gene therapy with a neurotrophic capsid in Niemann–Pick disease type C1 mice Open
Niemann–Pick C1 disease (NPC1) is a rare, fatal neurodegenerative disease caused by mutations in NPC1 , which encodes the lysosomal cholesterol transport protein NPC1. Disease pathology involves lysosomal accumulation of cholesterol and li…
View article: Investigate the origins of COVID-19
Investigate the origins of COVID-19 Open
On 30 December 2019, the Program for Monitoring Emerging Diseases notified the world about a pneumonia of unknown cause in Wuhan, China (1). Since then, scientists have made remarkable progress in understanding the causative agent, severe …