Benjamin E. Draper
2025
Insights into Adeno-Associated Virus Capsid Charge Heterogeneity
2025 • Jiaqi Wu, Benjamin E. Draper, Martin F. Jarrold, Christopher D. Heger
2025
End-to-end characterization of AAV manufacturing process using charge detection mass spectrometry
2025 • L. A. Young, Benjamin E. Draper, Martin F. Jarrold, Clifford A Froelich, Seyed Pouria Motevalian
2025
End-to-end characterization of AAV manufacturing process using charge detection mass spectrometry
2025 • L. A. Young, Benjamin E. Draper, Martin F. Jarrold, Clifford A Froelich, Seyed Pouria Motevalian
2025
Toward an all-in-one recombinant adeno-associated virus vector for functionally ablating the prion gene using CRISPR-Cas technology
2025 • Claire Verkuyl, Ari Belotserkovsky, Thomas Zerbes, Declan Williams, M. Krishnan, Sabrina Zhu, Sophie Grunnesjӧ, Shehab Eid, Cunjie Zhang, Wenda Zha...
2025
Coupling of Size Exclusion Chromatography to High Throughput Charge Detection Mass Spectrometry for the Analysis of Large Proteins and Virus-like Particles
2025 • Raj A. Parikh, Lohra M. Miller, Benjamin E. Draper, Lavelay Kizekai, Balasubrahmanyam Addepalli, Michelle H. Chen, Matthew Lauber, Martin F. Jarrold
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Exploring foci of
2025-01-29
Coupling of Size Exclusion Chromatography to High Throughput Charge Detection Mass Spectrometry for the Analysis of Large Proteins and Virus-like Particles
2025-01-29 • Raj A. Parikh, Lohra M. Miller, Benjamin E. Draper, Lavelay Kizekai, Balasubrahmanyam Addepalli, Michelle H. Chen, Matthew Lauber, Martin F. Jarrold
Charge detection mass spectrometry (CD-MS) is an emerging single-particle technique where both the <i>m</i>/<i>z</i> and charge are measured individually to determine each ion's mass. It is particularly well-suited for analyzing high mass and heterogeneous samples. With conventional MS, the loss of charge state resolution with high mass samples has hindered the direct coupling of MS to separation techniques like size exclusion chromatography (SEC) and forced the use of lower resolution detectors. Here, we show how…
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Fun Size
Railway Coupling
Pauli Exclusion Principle
Mid-Size Car
Shoe Size
Bed Size
Particle-Size Distribution
Bra Size
Oththa Seruppu Size 7
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Exploring foci of
2025-07-17
Insights into Adeno-Associated Virus Capsid Charge Heterogeneity
2025-07-17 • Jiaqi Wu, Benjamin E. Draper, Martin F. Jarrold, Christopher D. Heger
A comprehensive workflow is described to examine three contributing factors to the charge heterogeneity of Adeno-associated viruses (AAVs) from a single sample. Intact AAV9 capsids were fractionated using imaged capillary isoelectric focusing (icIEF)-based fractionation, allowing for collection of capsids with different isoelectric points (pIs). Capsid integrity of the fractions was confirmed with analytical icIEF and charge detection mass spectrometry (CD-MS). Using capillary electrophoresis (CE) immunoassays, th…
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Into The Jaws Of Death
Bloom Into You
A Brief Inquiry Into Online Relationships
Into The Night (Benny Mardones Song)
Into The Storm (2014 Film)
Into The Badlands (Tv Series)
Into Thin Air
Triumphal Entry Into Jerusalem
Down (Into The Dark)
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Exploring foci of
2025-10-06
End-to-end characterization of AAV manufacturing process using charge detection mass spectrometry
2025-10-06 • L. A. Young, Benjamin E. Draper, Martin F. Jarrold, Clifford A Froelich, Seyed Pouria Motevalian
Charge detection mass spectrometry (CD-MS) has previously been shown to be effective for analyzing predominantly clean bulk drug substances and drug products of recombinant adeno-associated virus (rAAV). CD-MS holds potential for assessing and monitoring the quality attributes of rAAV during the manufacturing process, from harvest to drug product. The mass range of rAAV material has been well characterized experimentally by CD-MS to agree with theoretical values for protein and target genome masses. CD-MS measures…
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Smart Manufacturing
Computer-Aided Manufacturing
List Of Manufacturing Processes
Lean Manufacturing
Murata Manufacturing
Manufacturing Consent
Manufacturing In The United States
Manufacturing Resource Planning
Manufacturing In Japan
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Exploring foci of
2025-11-05
End-to-end characterization of AAV manufacturing process using charge detection mass spectrometry
2025-11-05 • L. A. Young, Benjamin E. Draper, Martin F. Jarrold, Clifford A Froelich, Seyed Pouria Motevalian
[This corrects the article DOI: 10.1016/j.omtm.2025.101607.].
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Smart Manufacturing
List Of Manufacturing Processes
Flexible Manufacturing System
Murata Manufacturing
Textile Manufacturing
Manufacturing In Japan
Manufacturing
Boring (Manufacturing)
Computer-Aided Manufacturing
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Exploring foci of
2025-11-07
Toward an all-in-one recombinant adeno-associated virus vector for functionally ablating the prion gene using CRISPR-Cas technology
2025-11-07 • Claire Verkuyl, Ari Belotserkovsky, Thomas Zerbes, Declan Williams, M. Krishnan, Sabrina Zhu, Sophie Grunnesjӧ, Shehab Eid, Cunjie Zhang, Wenda Zha...
Any strategy that can selectively and persistently lower the brain levels of the cellular prion protein (PrP C ) is expected to extend survival in prion diseases. Recent advances in the virus-mediated delivery of gene therapies prompted us to explore if a recombinant adeno-associated virus (rAAV) vector delivering a CRISPR-Cas-based gene editor can be devised that induces a functional knockout of the prion gene. Whereas the eventual objective is to assess the therapeutic potency of an optimized vector in prion-inf…
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Regression Toward The Mean
Recombinant Dna
Societal Attitudes Toward Homosexuality
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