Benjamin E. Low
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View article: Retention of lysosomal acid sphingomyelinase protects from Niemann-Pick Disease
Retention of lysosomal acid sphingomyelinase protects from Niemann-Pick Disease Open
Niemann-Pick Disease (NPD) types A and B are lysosomal storage disorders resulting from dysfunction or loss of acid sphingomyelinase (aSMase), which hydrolyzes sphingomyelin (SM) to ceramide and phosphocholine. Patients with NPD-A develop …
View article: An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models
An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models Open
Although vaccines are usually given intramuscularly, the intranasal delivery route may lead to better mucosal protection and limit the spread of respiratory virus while easing administration and improving vaccine acceptance. The challenge,…
View article: Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis
Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis Open
Inhibitory G alpha (GNAI or Gαi) proteins are critical for the polarized morphogenesis of sensory hair cells and for hearing. The extent and nature of their actual contributions remains unclear, however, as previous studies did not investi…
View article: Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis
Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis Open
Inhibitory G alpha (GNAI or Gαi) proteins are critical for the polarized morphogenesis of sensory hair cells and for hearing. The extent and nature of their actual contributions remains unclear, however, as previous studies did not investi…
View article: Author Response: Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis
Author Response: Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis Open
Inhibitory G alpha (GNAI or Gαi) proteins are critical for the polarized morphogenesis of sensory hair cells and for hearing. The extent and nature of their actual contributions remains unclear, however, as previous studies did not investi…
View article: Dystonin modifiers of junctional epidermolysis bullosa and models of epidermolysis bullosa simplex without dystonia musculorum
Dystonin modifiers of junctional epidermolysis bullosa and models of epidermolysis bullosa simplex without dystonia musculorum Open
The Lamc2 jeb junctional epidermolysis bullosa (EB) mouse model has been used to demonstrate that significant genetic modification of EB symptoms is possible, identifying as modifiers Col17a1 and six other quantitative trait loci, several …
View article: Functional analysis of Collagen 17a1: A genetic modifier of junctional epidermolysis bullosa in mice
Functional analysis of Collagen 17a1: A genetic modifier of junctional epidermolysis bullosa in mice Open
Previous work strongly implicated Collagen 17a1 ( Col17a1 ) as a potent genetic modifier of junctional epidermolysis bullosa (JEB) caused by a hypomorphic mutation ( Lamc2 jeb ) in mice. The importance of the noncollagenous domain (NC4) of…
View article: Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis
Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis Open
Inhibitory G alpha (GNAI or Gαi) proteins are critical for the polarized morphogenesis of sensory hair cells and for hearing. The extent and nature of their actual contributions remains unclear, however, as previous studies did not investi…
View article: Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis
Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis Open
Inhibitory G alpha (GNAI or Gαi) proteins are critical for the polarized morphogenesis of sensory hair cells and for hearing. The extent and nature of their actual contributions remains unclear, however, as previous studies did not investi…
View article: Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis
Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis Open
Inhibitory G alpha (GNAI or Gαi) proteins are critical for the polarized morphogenesis of sensory hair cells and for hearing. The extent and nature of their actual contributions remains unclear, however, as previous studies did not investi…
View article: Supplementary Table 1 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Supplementary Table 1 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity Open
Genes that are differentially expressed among the subtypes.
View article: Supplementary Figure 2 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Supplementary Figure 2 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity Open
KM curve of 100 cell injection, quantization of Ki67 and Casp3 staining, and self-renewal of TICs.
View article: Supplementary Tables 1-5 from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma
Supplementary Tables 1-5 from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma Open
Supplementary Tables 1-5 from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma
View article: Supplementary Figure 5 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Supplementary Figure 5 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity Open
IPA analysis.
View article: Supplementary Figure 3 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Supplementary Figure 3 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity Open
Expression patterns of the SHH pathway genes in spontaneous Ptch tumors.
View article: Supplementary Methods from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Supplementary Methods from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity Open
Supplementary Methods
View article: Supplementary Figure 4 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Supplementary Figure 4 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity Open
FISH results from Ptch tumors that progressed to the GFI subtype during in vivo passaging.
View article: Supplementary Figure 1 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Supplementary Figure 1 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity Open
KM survival curve, quantitation of differentiated cells, and H&E of tumorsphere induced tumors.
View article: Data from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Data from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity Open
A central confounding factor in the development of targeted therapies is tumor cell heterogeneity, particularly in tumor-initiating cells (TIC), within clinically identical tumors. Here, we show how activation of the Sonic Hedgehog (SHH) p…
View article: Supplementary Figure 1 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Supplementary Figure 1 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity Open
KM survival curve, quantitation of differentiated cells, and H&E of tumorsphere induced tumors.
View article: Supplementary Figure Legends from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Supplementary Figure Legends from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity Open
Supplementary Figure Legends from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
View article: Data from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma
Data from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma Open
The recent identification of cancer stem cells (CSCs) in multiple human cancers provides a new inroad to understanding tumorigenesis at the cellular level. CSCs are defined by their characteristics of self-renewal, multipotentiality, and t…
View article: Supplementary Figure 1 from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma
Supplementary Figure 1 from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma Open
Supplementary Figure 1 from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma
View article: Supplementary Figure 2 from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma
Supplementary Figure 2 from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma Open
Supplementary Figure 2 from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma
View article: Supplementary Figure 3 from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma
Supplementary Figure 3 from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma Open
Supplementary Figure 3 from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma
View article: Data from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma
Data from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma Open
The recent identification of cancer stem cells (CSCs) in multiple human cancers provides a new inroad to understanding tumorigenesis at the cellular level. CSCs are defined by their characteristics of self-renewal, multipotentiality, and t…
View article: Supplementary Methods from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Supplementary Methods from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity Open
Supplementary Methods