Benjamin E. Steinberg
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View article: A modification to heptad repeat 1 of gp41 improves yield and/or quality of soluble pre-fusion HIV-1 envelope glycoprotein trimers
A modification to heptad repeat 1 of gp41 improves yield and/or quality of soluble pre-fusion HIV-1 envelope glycoprotein trimers Open
Native-like HIV-1 envelope glycoprotein (Env) trimers, exemplified by the SOSIP design, are widely used as immunogens, analytical antigens, and for structural studies. These vaccine research and development programs require trimers that ar…
View article: NINJ1 is activated by calcium-driven plasma membrane lipid scrambling during lytic cell death
NINJ1 is activated by calcium-driven plasma membrane lipid scrambling during lytic cell death Open
NINJ1 is the terminal executioner of cellular rupture in multiple lytic cell death pathways through its clustering in the plasma membrane. Its activation trigger, however, remains unknown. We found that NINJ1-mediated plasma membrane ruptu…
View article: Development and validation of a multivariable prediction model in pediatric liver transplant patients for predicting intensive care unit length of stay
Development and validation of a multivariable prediction model in pediatric liver transplant patients for predicting intensive care unit length of stay Open
Background Liver transplantation is the life‐saving treatment for many end‐stage pediatric liver diseases. The perioperative course, including surgical and anesthetic factors, have an important influence on the trajectory of this high‐risk…
View article: NINJ1 mediates plasma membrane rupture through formation of nanodisc-like rings
NINJ1 mediates plasma membrane rupture through formation of nanodisc-like rings Open
SUMMARY The membrane proteins Ninjurin1 ( NINJ1) and Ninjurin2 (NINJ2) are upregulated by nerve injury to increase cell adhesion and promote axonal growth in neurons. NINJ1, but not NINJ2, has also been shown to play an essential role in p…
View article: Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury
Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury Open
Plasma membrane rupture (PMR) in dying cells undergoing pyroptosis or apoptosis requires the cell-surface protein NINJ1 1 . PMR releases pro-inflammatory cytoplasmic molecules, collectively called damage-associated molecular patterns (DAMP…
View article: Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death
Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death Open
First recognized more than 30 years ago, glycine protects cells against rupture from diverse types of injury. This robust and widely observed effect has been speculated to target a late downstream process common to multiple modes of tissue…
View article: Author response: Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death
Author response: Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract First recog…
View article: Lipid peroxidation increases membrane tension, Piezo1 gating and cation permeability to execute ferroptosis
Lipid peroxidation increases membrane tension, Piezo1 gating and cation permeability to execute ferroptosis Open
The ongoing metabolic and microbicidal pathways that support and protect cellular life generate potentially damaging reactive oxygen species (ROS). To counteract damage, cells express peroxidases, antioxidant enzymes that catalyze the redu…
View article: Cholinergic modulation is independent of T lymphocytes in a mouse model of neuropathic pain
Cholinergic modulation is independent of T lymphocytes in a mouse model of neuropathic pain Open
T lymphocytes are increasingly implicated in pain signaling. A subset of T lymphocytes, termed TChAT, express the rate-limiting enzyme for acetylcholine (ACh) production, choline acetyltransferase (ChAT), and mediate numerous physiological…
View article: Inflammasome Activation in Pulmonary Arterial Hypertension
Inflammasome Activation in Pulmonary Arterial Hypertension Open
Inflammasomes are multi-protein complexes that sense both infectious and sterile inflammatory stimuli, launching a cascade of responses to propagate danger signaling throughout an affected tissue. Recent studies have implicated inflammasom…
View article: Glycine targets NINJ1-mediated plasma membrane rupture to provide cytoprotection
Glycine targets NINJ1-mediated plasma membrane rupture to provide cytoprotection Open
First recognized 35 years ago, glycine is known to protect cells against plasma membrane rupture from diverse types of tissue injury. This robust and widely observed effect has been speculated to target a late downstream process common to …
View article: Reporting of Participant Race, Sex, and Socioeconomic Status in Randomized Clinical Trials in General Medical Journals, 2015 vs 2019
Reporting of Participant Race, Sex, and Socioeconomic Status in Randomized Clinical Trials in General Medical Journals, 2015 vs 2019 Open
This cross-sectional study evaluates changes in reporting practices for race, sex, and socioeconomic status in randomized clinical trials in 2015 vs 2019.
View article: Modulation of Pathological Pain by Epidermal Growth Factor Receptor
Modulation of Pathological Pain by Epidermal Growth Factor Receptor Open
Chronic pain has been widely recognized as a major public health problem that impacts multiple aspects of patient quality of life. Unfortunately, chronic pain is often resistant to conventional analgesics, which are further limited by thei…
View article: General medical publications during COVID-19 show increased dissemination despite lower validation
General medical publications during COVID-19 show increased dissemination despite lower validation Open
Background The COVID-19 pandemic has yielded an unprecedented quantity of new publications, contributing to an overwhelming quantity of information and leading to the rapid dissemination of less stringently validated information. Yet, a fo…
View article: Endothelial HMGB1 Is a Critical Regulator of LDL Transcytosis via an SREBP2–SR-BI Axis
Endothelial HMGB1 Is a Critical Regulator of LDL Transcytosis via an SREBP2–SR-BI Axis Open
Objective: LDL (low-density lipoprotein) transcytosis across the endothelium is performed by the SR-BI (scavenger receptor class B type 1) receptor and contributes to atherosclerosis. HMGB1 (high mobility group box 1) is a structural prote…
View article: Indirect regulation of HMGB1 release by gasdermin D
Indirect regulation of HMGB1 release by gasdermin D Open
The protein high-mobility group box 1 (HMGB1) is released into the extracellular space in response to many inflammatory stimuli, where it is a potent signaling molecule. Although research has focused on downstream HMGB1 signaling, the mean…
View article: Reporting preclinical anesthesia study (REPEAT): Evaluating the quality of reporting in the preclinical anesthesiology literature
Reporting preclinical anesthesia study (REPEAT): Evaluating the quality of reporting in the preclinical anesthesiology literature Open
Poor reporting quality may contribute to irreproducibility of results and failed 'bench-to-bedside' translation. Consequently, guidelines have been developed to improve the complete and transparent reporting of in vivo preclinical studies.…
View article: Inflammatory Basis of Pulmonary Arterial Hypertension
Inflammatory Basis of Pulmonary Arterial Hypertension Open
Patients with pulmonary arterial hypertension have exceptionally high perioperative risk. This review summarizes the clinical presentation and therapies for PAH, and highlights evidence for inflammation as a driver of disease pathogenesis …
View article: Inflammation Drives Pulmonary Arterial Hypertension
Inflammation Drives Pulmonary Arterial Hypertension Open
Patients with pulmonary arterial hypertension (Group 1 pulmonary hypertension, including idiopathic, heritable, connective tissue disease–associated, congenital heart disease–associated pulmonary arterial hypertension, and others) present …
View article: Therapeutic Targeting of High-Mobility Group Box-1 in Pulmonary Arterial Hypertension
Therapeutic Targeting of High-Mobility Group Box-1 in Pulmonary Arterial Hypertension Open
To the Editor:The importance of the immune system in pulmonary arterial hypertension (PAH) pathogenesis is increasingly recognized by clinicians and scientists (1).Immune cells are recruited to the lungs of patients with PAH (2), and precl…
View article: Wide Variation in Opioid Prescribing Practices after Discharge in a Pediatric Teaching Hospital
Wide Variation in Opioid Prescribing Practices after Discharge in a Pediatric Teaching Hospital Open
Introduction/Aim: Opioid analgesics are frequently used for the treatment of acute pain in children following hospital discharge. In adults, opioid use can lead to overdose, diversion, and dependency. However, data on opioids prescription …
View article: Choline acetyltransferase–expressing T cells are required to control chronic viral infection
Choline acetyltransferase–expressing T cells are required to control chronic viral infection Open
ChAT-ty T cells fight viral infection The neurotransmitter acetylcholine (ACh) is involved in processes such as muscle contraction, neuron communication, and vasodilation. Along with neurons, a population of immunological T cells and B cel…
View article: Postnatal DNA demethylation and its role in tissue maturation
Postnatal DNA demethylation and its role in tissue maturation Open
Development in mammals is accompanied by specific de novo and demethylation events that are thought to stabilize differentiated cell phenotypes. We demonstrate that a large percentage of the tissue-specific methylation pattern is generated…