Benjamin E. Zuchelkowski
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Increased Neutrophil H2O2 Production and Enhanced Pulmonary Clearance of Klebsiella pneumoniae in G6PD A- Mice Open
The X-linked A- variant (rs1050828, Val68Met) in G6PDX accounts for glucose-6-phosphate (G6PD) deficiency in approximately 11% of African American males. This common, hypomorphic variant may impact pulmonary host defense and phagocyte func…
Functional effects of an African glucose‐6‐phosphate dehydrogenase (G6PD) polymorphism (<span>Val68Met</span>) on <span>red blood cell</span> hemolytic propensity and post‐transfusion recovery Open
Background Donor genetic variation is associated with red blood cell (RBC) storage integrity and post‐transfusion recovery. Our previous large‐scale genome‐wide association study demonstrated that the African G6PD deficient A‐ variant (rs1…
Brief Report: Hydroxychloroquine does not induce hemolytic anemia or organ damage in a “humanized” G6PD A- mouse model Open
Though the effects of high doses over prolonged periods was not assessed, this study provides early, novel safety data of the use of HCQ in the setting of G6PD deficiency secondary to G6PD A-. In addition to novel safety data for HCQ, to o…