Benjamin Eggerstorfer
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View article: Oral ketamine for the treatment of major depressive and bipolar disorder, a randomized controlled trial and meta-analysis
Oral ketamine for the treatment of major depressive and bipolar disorder, a randomized controlled trial and meta-analysis Open
Ketamine represents a significant advancement in antidepressant therapy, but the commonly used intravenous and intranasal application routes currently limit its availability beyond specialized centers. By contrast, oral ketamine treatment …
View article: Hedonic experiences emerge from an orchestrated balance of synergistic and redundant information processing
Hedonic experiences emerge from an orchestrated balance of synergistic and redundant information processing Open
Ketamine exerts rapid-acting, pro-hedonic effects, yet its precise mechanism remains elusive. Here, we present behavioral and fMRI data from a randomized, placebo-controlled crossover study in 38 healthy participants investigating ketamine…
View article: High-temporal resolution metabolic connectivity resolved by component-based noise correction
High-temporal resolution metabolic connectivity resolved by component-based noise correction Open
Recent advances in functional PET (fPET) allow for accurate modelling of metabolic processes with a temporal resolution in the range of seconds. This enables new applications such as imaging molecular connectivity at temporal resolutions c…
View article: Phenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder
Phenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder Open
With their ability to cross the blood-brain barrier, transport and regulate the release of various signaling molecules, extracellular vesicles (EVs) constitute a novel avenue to study intercellular communication in various pathologies, inc…
View article: Oral Ketamine for the Treatment of Depression: A randomized controlled trial and meta-analysis
Oral Ketamine for the Treatment of Depression: A randomized controlled trial and meta-analysis Open
Ketamine represents a significant advancement in antidepressant therapy, but the commonly used intravenous and intranasal application routes currently limit its availability beyond specialized centers. By contrast, oral ketamine treatment …
View article: Phenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder
Phenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder Open
With their ability to cross the blood-brain barrier, transport and regulate the release of various signaling molecules, extracellular vesicles (EVs) constitute a novel avenue to study intercellular communication in various pathologies, inc…
View article: FUNCTIONAL DYNAMICS OF SEROTONIN SYNTHESIS DURING MONETARY REWARD AND PUNISHMENT PROCESSING – A HYBRID FPET/FMRI STUDY
FUNCTIONAL DYNAMICS OF SEROTONIN SYNTHESIS DURING MONETARY REWARD AND PUNISHMENT PROCESSING – A HYBRID FPET/FMRI STUDY Open
Background Reward processing is implicated in everyday functioning and several psychiatric conditions including major depressive disorder. The monetary incentive delay (MID) task and functional magnetic resonance imaging (fMRI) are widely …
View article: MULTIMODAL ASSESSMENT OF DOPAMINE SYNTHESIS AND BOLD- SIGNALING IN REWARD AND PUNISHMENT PROCESSING - A HYBRID FPET/FMRI STUDY
MULTIMODAL ASSESSMENT OF DOPAMINE SYNTHESIS AND BOLD- SIGNALING IN REWARD AND PUNISHMENT PROCESSING - A HYBRID FPET/FMRI STUDY Open
Background The monetary incentive delay (MID) task has been regularly used to assess reward and punishment processing, especially in combination with functional magnetic resonance imaging (fMRI) [1].Previous work by our group has proposed …
View article: EXTRACELLULAR VESICLES IN MAJOR DEPRESSIVE DISORDER AND THEIR RELATIONSHIP TO TREATMENT OUTCOME
EXTRACELLULAR VESICLES IN MAJOR DEPRESSIVE DISORDER AND THEIR RELATIONSHIP TO TREATMENT OUTCOME Open
Background Extracellular vesicles (EVs) play a crucial role in facilitating intercellular communication. Their capacity to traverse the blood-brain barrier, transport, and control the release of diverse neurotransmitters underscores their …
View article: Validation of cardiac image-derived input functions for functional PET quantification
Validation of cardiac image-derived input functions for functional PET quantification Open
Purpose Functional PET (fPET) is a novel technique for studying dynamic changes in brain metabolism and neurotransmitter signaling. Accurate quantification of fPET relies on measuring the arterial input function (AIF), traditionally achiev…
View article: Validation of cardiac image derived input functions for functional PET quantification
Validation of cardiac image derived input functions for functional PET quantification Open
Functional PET (fPET) is a novel technique for studying dynamic changes in brain metabolism and neurotransmitter signaling. Accurate measurement of the arterial input function (AIF) is crucial for quantification of fPET but traditionally r…
View article: Meta-analysis of molecular imaging of translocator protein in major depression
Meta-analysis of molecular imaging of translocator protein in major depression Open
Molecular neuroimaging studies provide mounting evidence that neuroinflammation plays a contributory role in the pathogenesis of major depressive disorder (MDD). This has been the focus of a number of positron emission tomography (PET) stu…