Benjamin D. Elder
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View article: Visible Light Induced DLP‐Printed Oxygen‐Releasing TPMS Scaffolds Mitigate Early Hypoxia in Bone Defects
Visible Light Induced DLP‐Printed Oxygen‐Releasing TPMS Scaffolds Mitigate Early Hypoxia in Bone Defects Open
Oxygen deprivation within large or poorly vascularized bone defects remains a key barrier to successful regeneration, especially during the early postimplantation period before vascular ingrowth. Here, the development of COSnPPOD (CaO 2 –S…
View article: Unsupervised machine learning identifies clinically relevant patterns of CSF dynamic dysfunction in normal pressure hydrocephalus
Unsupervised machine learning identifies clinically relevant patterns of CSF dynamic dysfunction in normal pressure hydrocephalus Open
NMF-generated patterns of CSF distribution showed high accuracy in discerning individuals with iNPH from controls. The patterns most relying on DESH features showed highest potential for independently predicting NPH diagnosis. The algorith…
View article: A Randomized Trial of Shunting for Idiopathic Normal-Pressure Hydrocephalus
A Randomized Trial of Shunting for Idiopathic Normal-Pressure Hydrocephalus Open
Among participants with idiopathic normal-pressure hydrocephalus who had a response to temporary CSF drainage, shunting resulted in significant improvements at 3 months in gait velocity and a measure of gait and balance but not in measures…
View article: Magnetic Resonance Imaging-Based Assessment of Bone Quality Using Vertebral Bone Quality (VBQ) Scores in Spine Surgery—A Critical Assessment and Narrative Review
Magnetic Resonance Imaging-Based Assessment of Bone Quality Using Vertebral Bone Quality (VBQ) Scores in Spine Surgery—A Critical Assessment and Narrative Review Open
Bone health is a key determinant of success in spine surgery, making preoperative assessment of bone quality essential to optimal surgical risk stratification. Magnetic resonance imaging (MRI)-based vertebral bone quality (VBQ) score offer…
View article: Lumbar Endplate Hounsfield Units Enhance Transforaminal Lumbar Interbody Fusion Subsidence Prediction Compared to Trabecular Hounsfield Units Alone
Lumbar Endplate Hounsfield Units Enhance Transforaminal Lumbar Interbody Fusion Subsidence Prediction Compared to Trabecular Hounsfield Units Alone Open
Study Design Retrospective cohort analysis. Objective (1) Develop a novel computed tomography (CT)-based assessment of endplate bone density (EP-HU), (2) Determine if EP-HU was a stronger predictor than trabecular HU for subsidence after t…
View article: Distal junctional failure following pelvic instrumentation in spinal fusion: a novel classification system
Distal junctional failure following pelvic instrumentation in spinal fusion: a novel classification system Open
OBJECTIVE While traditional literature in adult spinal deformity (ASD) examining mechanical complications has focused on proximal junctional kyphosis and failure, distal junctional failure (DJF) of constructs ending at the sacrum with or w…
View article: Removal of painful pelvic screws following spine fusion surgery: outcomes and complications
Removal of painful pelvic screws following spine fusion surgery: outcomes and complications Open
OBJECTIVE The purpose of this study was to evaluate the risks and benefits of removing painful pelvic/iliac screws in spine fusion surgery patients. METHODS A retrospective review identified patients who had traditional iliac and S2-alar-i…
View article: Do Three-Dimensional Printed Porous Titanium Relative to Polyetheretherketone Interbody Cages Reduce Complications and Revisions after Transforaminal Lumbar Interbody Fusion?
Do Three-Dimensional Printed Porous Titanium Relative to Polyetheretherketone Interbody Cages Reduce Complications and Revisions after Transforaminal Lumbar Interbody Fusion? Open
Study Design Retrospective Cohort Study. Objectives To determine if 3D printed porous titanium (Ti) cages compared to non-porous polyetheretherketone (PEEK) cages predicted improved fusion rate or clinical outcomes after transforaminal lum…
View article: Impact of Frailty and Other Factors as Estimated by HU to Predict Response to Anabolic Bone Medications
Impact of Frailty and Other Factors as Estimated by HU to Predict Response to Anabolic Bone Medications Open
Introduction: Bone health optimization is a key component of the preoperative management of spine surgery patients, as poor bone quality increases the odds of mechanical complications. The present study aimed to achieve the following: (1) …
View article: Risk factors for early pathological fracture following stereotactic body radiation therapy for spinal metastases
Risk factors for early pathological fracture following stereotactic body radiation therapy for spinal metastases Open
OBJECTIVE The aim of this study was to determine independent risk factors for vertebral compression fracture (VCF) following stereotactic body radiation therapy (SBRT) in metastatic spine disease. METHODS Patients treated with SBRT for spi…
View article: Surgical management of tic-induced myelopathy and the importance of perioperative tic control: illustrative cases
Surgical management of tic-induced myelopathy and the importance of perioperative tic control: illustrative cases Open
BACKGROUND Degenerative cervical myelopathy (DCM) is the most common cause of adult spinal cord dysfunction. Tourette syndrome (TS) represents a rare cause of DCM that is incompletely characterized in the literature. Patients with TS might…
View article: The Paraspinal Sarcopenia at the Upper Instrumented Vertebra Is a Predictor of Discoligamentous but Not Bony Proximal Junctional Kyphosis
The Paraspinal Sarcopenia at the Upper Instrumented Vertebra Is a Predictor of Discoligamentous but Not Bony Proximal Junctional Kyphosis Open
Background/Objectives: Both poor bone quality and paraspinal sarcopenia have been suggested as risk factors for proximal junctional kyphosis (PJK) at the upper instrumented vertebra (UIV) following long-segment thoracolumbar fusion. Method…
View article: Real‐Time 2D Phase‐Contrast MRI to Assess Cardiac‐ and Respiratory‐Driven CSF Movement in Normal Pressure Hydrocephalus
Real‐Time 2D Phase‐Contrast MRI to Assess Cardiac‐ and Respiratory‐Driven CSF Movement in Normal Pressure Hydrocephalus Open
Background and Purpose In idiopathic normal pressure hydrocephalus (iNPH) patients, cerebrospinal fluid (CSF) flow is typically evaluated with a cardiac‐gated two‐dimensional (2D) phase‐contrast (PC) MRI through the cerebral aqueduct. This…
View article: 3D bioprinted chondrogenic gelatin methacrylate-poly(ethylene glycol) diacrylate composite scaffolds for intervertebral disc restoration
3D bioprinted chondrogenic gelatin methacrylate-poly(ethylene glycol) diacrylate composite scaffolds for intervertebral disc restoration Open
Degenerative spine pathologies, including intervertebral disc (IVD) degeneration, present a significant healthcare challenge due to their association with chronic pain and disability. This study explores an innovative approach to IVD regen…
View article: Quantifying CSF Dynamics disruption in idiopathic normal pressure hydrocephalus using phase lag between transmantle pressure and volumetric flow rate
Quantifying CSF Dynamics disruption in idiopathic normal pressure hydrocephalus using phase lag between transmantle pressure and volumetric flow rate Open
The exact mechanism causing the disruption of CSF circulation in idiopathic normal pressure hydrocephalus (iNPH) remains unclear. Elucidating the pathophysiology of iNPH is crucial, as it is a treatable cause of dementia. In this study, we…
View article: Paraspinal Sarcopenia and Lower Hounsfield Units are Independent Predictors of Increased Risk for Proximal Junctional Complications Following Thoracolumbar Fusions Terminating in the Upper Thoracic Spine
Paraspinal Sarcopenia and Lower Hounsfield Units are Independent Predictors of Increased Risk for Proximal Junctional Complications Following Thoracolumbar Fusions Terminating in the Upper Thoracic Spine Open
Study Design Retrospective cohort study. Objective The impact of paraspinal sarcopenia following fusions that extend to the upper thoracic spine remain unknown. The purpose of the present study was to assess the impact of sarcopenia on the…
View article: Assessing the Fractional Curve for Proper Management of Adult Degenerative Scoliosis
Assessing the Fractional Curve for Proper Management of Adult Degenerative Scoliosis Open
Adult degenerative scoliosis (ADS) is a coronal plane deformity often accompanied by sagittal plane malalignment. Surgical correction may involve the major and/or distally-located fractional curves (FCs). Correction of the FC has been incr…
View article: Injectable bioactive poly(propylene fumarate) and polycaprolactone based click chemistry bone cement for spinal fusion in rabbits
Injectable bioactive poly(propylene fumarate) and polycaprolactone based click chemistry bone cement for spinal fusion in rabbits Open
Degenerative spinal pathology is a widespread medical issue, and spine fusion surgeries are frequently performed. In this study, we fabricated an injectable bioactive click chemistry polymer cement for use in spinal fusion and bone regrowt…
View article: Biodegradable poly(caprolactone fumarate) 3D printed scaffolds for segmental bone defects within the Masquelet technique
Biodegradable poly(caprolactone fumarate) 3D printed scaffolds for segmental bone defects within the Masquelet technique Open
Segmental bone defects, often clinically treated with nondegradable poly(methylmethacrylate) (PMMA) in multistage surgeries, present a significant clinical challenge. Our study investigated the efficacy of 3D printed biodegradable polycapr…
View article: Significant Reduction in Bone Density as Measured by Hounsfield Units in Patients with Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis
Significant Reduction in Bone Density as Measured by Hounsfield Units in Patients with Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis Open
Background: Multisegmental pathologic autofusion occurs in patients with ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH). It may lead to reduced vertebral bone density due to stress shielding. Methods: This …
View article: Prediction of Surgical Outcomes in Normal Pressure Hydrocephalus by MR Elastography
Prediction of Surgical Outcomes in Normal Pressure Hydrocephalus by MR Elastography Open
MR elastography provides further insight into mechanical alterations in the normal pressure hydrocephalus brain and is a promising, noninvasive method for predicting surgical outcomes in patients with normal pressure hydrocephalus.
View article: 3D Stem Cell Spheroids with 2D Hetero‐Nanostructures for In Vivo Osteogenic and Immunologic Modulated Bone Repair
3D Stem Cell Spheroids with 2D Hetero‐Nanostructures for In Vivo Osteogenic and Immunologic Modulated Bone Repair Open
3D stem cell spheroids have immense potential for various tissue engineering applications. However, current spheroid fabrication techniques encounter cell viability issues due to limited oxygen access for cells trapped within the core, as …
View article: Patients with normal pressure hydrocephalus have fewer enlarged perivascular spaces in the centrum semiovale compared to cognitively unimpaired individuals
Patients with normal pressure hydrocephalus have fewer enlarged perivascular spaces in the centrum semiovale compared to cognitively unimpaired individuals Open
Fewer centrum semiovale ePVS may be a biomarker for iNPH. This pattern may be caused by mechanical obstruction due to upward displacement of the brain leading to reduced glymphatic clearance.
View article: The Predictors of Incidental Durotomy in Patients Undergoing Pedicle Subtraction Osteotomy for the Correction of Adult Spinal Deformity
The Predictors of Incidental Durotomy in Patients Undergoing Pedicle Subtraction Osteotomy for the Correction of Adult Spinal Deformity Open
Background: Pedicle subtraction osteotomy (PSO) is a powerful tool for sagittal plane correction in patients with rigid adult spinal deformity (ASD); however, it is associated with high intraoperative blood loss and the increased risk of d…
View article: Normal pressure hydrocephalus, or Hakim syndrome: review and update
Normal pressure hydrocephalus, or Hakim syndrome: review and update Open
This review makes the case that idiopathic normal pressure hydrocephalus (iNPH) is an outdated term because new information indicates that the syndrome is less idiopathic and that the cerebrospinal fluid (CSF) pressure of normal individual…