Benjamin Feiner
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View article: How time influences episiotomy utilization and obstetric anal sphincter injuries (OASIS)
How time influences episiotomy utilization and obstetric anal sphincter injuries (OASIS) Open
Objectives Obstetric anal sphincter injuries (OASIS) pose significant challenges for young women following childbirth. The association between mediolateral episiotomy and OASIS remains a subject of debate and uncertainty. This study seeks …
View article: Transvaginal ultrasound imaging of female urethral diverticulum before and after voiding
Transvaginal ultrasound imaging of female urethral diverticulum before and after voiding Open
Female urethral diverticulum is a localized ‘sac-like’ herniation between the periurethral fibromuscular layer and anterior vaginal wall, which is continuous with the lumen of the urethra. It is estimated to occur in 0.6–6% of women, most …
View article: Monocyte Transcriptional Profiling Highlights a Shift in Immune Signatures Over the Course of Illness in Schizophrenia
Monocyte Transcriptional Profiling Highlights a Shift in Immune Signatures Over the Course of Illness in Schizophrenia Open
With advanced understanding of the intricate interplay between the immune and central nervous systems in neurological and neuropsychiatric illness, there is renewed interest in the potential contribution of immune dysregulation to the deve…
View article: Examining the effects of the histone methyltransferase inhibitor BIX-01294 on histone modifications and gene expression in both a clinical population and mouse models
Examining the effects of the histone methyltransferase inhibitor BIX-01294 on histone modifications and gene expression in both a clinical population and mouse models Open
Schizophrenia has been consistently characterized by abnormal patterns of gene down-regulation, increased restrictive chromatin assemblies, and reduced transcriptional activity. Histone methyltransferase (HMT) mRNA and H3K9me2 levels are e…
View article: Risperidone effects on heterochromatin: the role of kinase signaling
Risperidone effects on heterochromatin: the role of kinase signaling Open
Summary Epigenetic effects of anti-psychotic medications are poorly understood. We have appropriated a model whereby heterochromatin is established through 24- or 48-h lipopolysaccharide (LPS) treatment, and tested the epigenetic effects o…
View article: Surgery for women with anterior compartment prolapse
Surgery for women with anterior compartment prolapse Open
Transvaginal repair may be more effective than transanal repair for posterior wall prolapse in preventing recurrence of prolapse, in the light of both objective and subjective measures. However, data on adverse effects were scanty. Evidenc…
View article: Surgery for women with apical vaginal prolapse
Surgery for women with apical vaginal prolapse Open
Sacral colpopexy is associated with lower risk of awareness of prolapse, recurrent prolapse on examination, repeat surgery for prolapse, postoperative SUI and dyspareunia than a variety of vaginal interventions.The limited evidence does no…
View article: Transvaginal mesh or grafts compared with native tissue repair for vaginal prolapse
Transvaginal mesh or grafts compared with native tissue repair for vaginal prolapse Open
While transvaginal permanent mesh is associated with lower rates of awareness of prolapse, reoperation for prolapse, and prolapse on examination than native tissue repair, it is also associated with higher rates of reoperation for prolapse…
View article: Activated Phosphorylated STAT1 Levels as a Biologically Relevant Immune Signal in Schizophrenia
Activated Phosphorylated STAT1 Levels as a Biologically Relevant Immune Signal in Schizophrenia Open
Objective: Activation of STAT1 is directly downstream of the cytokine receptors that signal from specific proinflammatory cytokines known to be dysregulated in schizophrenia (SZ), such as IFNγ, IL6, IL2 and IL10, as well as hypoxia,…