Gary Rajah
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View article: Efficacy and procedural efficiency of mechanical thrombectomy devices in posterior circulation stroke
Efficacy and procedural efficiency of mechanical thrombectomy devices in posterior circulation stroke Open
Background and purpose Posterior circulation stroke patients have worse outcomes after mechanical thrombectomy (MT) and higher mortality than anterior circulation acute ischemic stroke (AIS) patients due to large vessel occlusions (LVOs). …
View article: Prospective randomized controlled trial on the safety and neuroprotective efficacy of remote administration of hypothermia over spleen during acute ischemic stroke with mechanical thrombectomy: rationale, design, and protocol
Prospective randomized controlled trial on the safety and neuroprotective efficacy of remote administration of hypothermia over spleen during acute ischemic stroke with mechanical thrombectomy: rationale, design, and protocol Open
Background Brain inflammation plays a key role in ischemia/reperfusion (I/R) injury and is the main cause of “ineffective or futile recanalization” after successful mechanical thrombectomy (MT) in acute ischemic stroke (AIS). One of the pr…
View article: Time and Tissue Windows in Futile Reperfusion after Ischemic Stroke
Time and Tissue Windows in Futile Reperfusion after Ischemic Stroke Open
Reperfusion strategies such as vascular thrombolysis and thrombectomy are the first-line treatments recommended for acute ischemic stroke. However, only half of these patients achieve functional independence after endovascular reperfusion …
View article: External Validation of Atherosclerotic Neuroimaging Biomarkers in Emergent Large‐Vessel Occlusion
External Validation of Atherosclerotic Neuroimaging Biomarkers in Emergent Large‐Vessel Occlusion Open
Background Intracranial atherosclerosis related large vessel occlusion (ICAS‐LVO) is the major cause of failed mechanical thrombectomy. ICAS‐LVO causes reocclusion or a fixed focal stenosis, leading to suboptimal revascularization and poor…
View article: Arterial Glyceryl Trinitrate in Acute Ischemic Stroke after Thrombectomy for Neuroprotection (AGAIN)：A Pilot Randomized Controlled Trial
Arterial Glyceryl Trinitrate in Acute Ischemic Stroke after Thrombectomy for Neuroprotection (AGAIN)：A Pilot Randomized Controlled Trial Open
Although endovascular therapy demonstrates robust clinical efficacy in acute ischemic stroke (AIS), not all stroke patients benefit from successful reperfusion. This study aimed to evaluate the safety, feasibility, and preliminary efficacy…
View article: Vertebrobasilar artery cooling infusion in acute ischemic stroke for posterior circulation following thrombectomy: Rationale, design and protocol for a prospective randomized controlled trial
Vertebrobasilar artery cooling infusion in acute ischemic stroke for posterior circulation following thrombectomy: Rationale, design and protocol for a prospective randomized controlled trial Open
Background Although endovascular mechanical thrombectomy demonstrates clinical efficacy in posterior circulation acute ischemic stroke (AIS), only one third of these patients attain functional independence with a third of patients’ expirin…
View article: Large vessel occlusion stroke outcomes in diabetic vs. non-diabetic patients with acute stress hyperglycemia
Large vessel occlusion stroke outcomes in diabetic vs. non-diabetic patients with acute stress hyperglycemia Open
Objective This study assesses whether stress-induced hyperglycemia is a predictor of poor outcome at 3 months for patients with acute ischemic stroke (AIS) treated by endovascular treatment (EVT) and impacted by their previous blood glucos…
View article: Endovascular Therapy vs Medical Management for Patients With Acute Stroke With Medium Vessel Occlusion in the Anterior Circulation
Endovascular Therapy vs Medical Management for Patients With Acute Stroke With Medium Vessel Occlusion in the Anterior Circulation Open
Importance Randomized clinical trials have shown the efficacy of endovascular therapy (EVT) for acute large vessel occlusion strokes. The benefit of EVT in acute stroke with distal, medium vessel occlusion (DMVO) remains unclear. Objective…
View article: Imaging features of adult moyamoya disease patients with anterior intracerebral hemorrhage based on high-resolution magnetic resonance imaging
Imaging features of adult moyamoya disease patients with anterior intracerebral hemorrhage based on high-resolution magnetic resonance imaging Open
This study aimed to identify the high-resolution magnetic resonance imaging (HRMRI) features of moyamoya disease (MMD) patients with anterior intracerebral hemorrhage (ICH) and attempted to reveal potential mechanisms of anterior ICH. Elig…
View article: Daily Remote Ischemic Conditioning Can Improve Cerebral Perfusion and Slow Arterial Progression of Adult Moyamoya Disease—A Randomized Controlled Study
Daily Remote Ischemic Conditioning Can Improve Cerebral Perfusion and Slow Arterial Progression of Adult Moyamoya Disease—A Randomized Controlled Study Open
Background and Purpose Moyamoya disease (MMD) is a complicated cerebrovascular disease with recurrent ischemic or hemorrhagic events. This study aimed to prove the safety and efficacy of remote ischemic conditioning (RIC) on MMD. Methods I…
View article: Rapid Intravenous Glyceryl Trinitrate in Ischemic Damage (RIGID) After Stroke: Rationale, Design and Protocol for a Prospective Randomized Controlled Trial
Rapid Intravenous Glyceryl Trinitrate in Ischemic Damage (RIGID) After Stroke: Rationale, Design and Protocol for a Prospective Randomized Controlled Trial Open
Background: Despite intravenous thrombolysis and endovascular therapy for acute ischemic stroke (AIS), many survivors still have varying degrees of disability. Glyceryl trinitrate (GTN), a nitric oxide (NO) donor, has been previously repor…
View article: Rapid Intervention of Chlorpromazine and Promethazine for Hibernation-Like Effect in Stroke: Rationale, Design, and Protocol for a Prospective Randomized Controlled Trial
Rapid Intervention of Chlorpromazine and Promethazine for Hibernation-Like Effect in Stroke: Rationale, Design, and Protocol for a Prospective Randomized Controlled Trial Open
Background: Following an acute ischemic stroke (AIS), rapidly initiated reperfusion therapies [i. e., intravenous thrombolysis (IVT) and endovascular treatment (EVT)] demonstrate robust clinical efficacy. However, only a subset of these pa…
View article: NIHSS Consciousness Score Combined with ASPECTS is a Favorable Predictor of Functional Outcome post Endovascular Recanalization in Stroke Patients
NIHSS Consciousness Score Combined with ASPECTS is a Favorable Predictor of Functional Outcome post Endovascular Recanalization in Stroke Patients Open
Although revascularization rates after endovascular thrombectomy for large vessel acute ischemic stroke (AIS) are high (71%), only 46% of patients achieve functional independence at 90 days. The present study was designed to explore a new …
View article: Identifying Biomarkers Associated with Venous Infarction in Acute/Subacute Cerebral Venous Thrombosis
Identifying Biomarkers Associated with Venous Infarction in Acute/Subacute Cerebral Venous Thrombosis Open
Among cerebral venous thrombosis (CVT) patients, those with venous infarction have more severe clinical presentations and worse outcomes. Identifying biomarkers associated with venous infarction in CVT may help understand the pathogenesis …
View article: Outcomes in Endovascular Therapy for Basilar Artery Occlusion: Intracranial Atherosclerotic Disease vs. Embolism
Outcomes in Endovascular Therapy for Basilar Artery Occlusion: Intracranial Atherosclerotic Disease vs. Embolism Open
Acute ischemic stroke due to basilar artery occlusion (BAO) carries a very poor prognosis. Functional outcomes in BAO patients undergoing endovascular therapy (EVT) may differ according to the specific pathological mechanisms. We aimed to …
View article: Use of expandable stent retriever for mechanical thrombectomy of the right internal carotid artery terminus occlusion
Use of expandable stent retriever for mechanical thrombectomy of the right internal carotid artery terminus occlusion Open
Background: Tigertriever (Rapid Medical, Sunrise, FL) is an adjustable-diameter stent retriever that is being tested in an investigational device exemption clinical trial, Treatment with Intent to Generate Reperfusion (TIGER). The retrieve…
View article: E-105 Learning curve for diagnostic cerebral angiography: transradial access versus transfemoral access
E-105 Learning curve for diagnostic cerebral angiography: transradial access versus transfemoral access Open
Background Diagnostic cerebral angiography (DSA) and neurointerventions have traditionally been performed via transfemoral access (TFA). The perception of a steep learning curve associated with transradial access (TRA) has limited adoption…
View article: E-052 Safety and efficacy of stenting post failed thrombectomy: multi-institutional experience
E-052 Safety and efficacy of stenting post failed thrombectomy: multi-institutional experience Open
Introduction Even in the era of stent-retrievers, complete recanalization is often not achieved. Methods In this multi-institutional effort, we retrospectively evaluated 101 consecutive patients across 6 centers who underwent placement of …
View article: E-038 Transradial neuro-angiography by re-wiring of arterial line
E-038 Transradial neuro-angiography by re-wiring of arterial line Open
Background The advantages of transradial neuroangiography over a transfemoral access with respect to fewer access site complications, shorter procedure duration and better patient comfort are well described. Radial arterial lines are routi…
View article: E-134 Trans-ulnar access for neurointervention: pushing the boundaries of arterial access
E-134 Trans-ulnar access for neurointervention: pushing the boundaries of arterial access Open
Background Transradial access has been gaining popularity in neurointerventional surgery. Failure to obtain radial access may lead neurointerventionists to convert to a transfemoral approach, which is associated with a higher complication …
View article: E-126 Trans radial onyx middle meningeal artery embolization for subacute chronic SDH: single center series
E-126 Trans radial onyx middle meningeal artery embolization for subacute chronic SDH: single center series Open
Introduction Middle meningeal artery (MMA) embolization for the treatment of subacute/chronic subdural hematoma (cSDH) is an emerging therapy for minimally invasive treatment of subdural blood products. Trans radial access (TRA) may offer …
View article: Transradial access for flow diversion of intracranial aneurysms: Case series
Transradial access for flow diversion of intracranial aneurysms: Case series Open
Background Transradial access for neurointerventions offers advantages of fewer access-site complications, reduced procedure time, and greater patient comfort over transfemoral access. Data about transradial access for flow diversion are l…
View article: Trans-cranial Doppler predicts early neurologic deterioration in anterior circulation ischemic stroke after successful endovascular treatment
Trans-cranial Doppler predicts early neurologic deterioration in anterior circulation ischemic stroke after successful endovascular treatment Open
Background Early neurologic deterioration (END) may occur in patients with anterior circulation ischemic stroke (ACIS) after receiving endovascular treatment (EVT). Hemodynamic insufficiency, re-occlusion, and post-re-canalization hyper-pe…
View article: Clinical manifestation of non-ketotic hyperglycemia chorea
Clinical manifestation of non-ketotic hyperglycemia chorea Open
Introduction: Chorea is considered a special complication of diabetes mellitus. Here we report a case of chorea associated with non-ketotic hyperglycemia (NKH). Patient concerns: The patient was a 79-year-old Asian woman. She had a history…