Benjamin Georgi
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View article: FRONTIER-3: a randomised phase 2a study to investigate tozorakimab (an anti-IL-33 mAb) in early onset asthma
FRONTIER-3: a randomised phase 2a study to investigate tozorakimab (an anti-IL-33 mAb) in early onset asthma Open
Background IL-33 is implicated in the initiation and progression of asthma. FRONTIER-3 ( NCT04570657 ) was a phase 2a study to investigate tozorakimab, an anti-IL-33 monoclonal antibody, in adults with moderate-to-severe early-onset asthma…
View article: Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences
Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences Open
Telomeres protect chromosome ends from damage and their length is linked with human disease and aging. We developed a joint telomere length metric, combining quantitative PCR and whole-genome sequencing measurements from 462,666 UK Biobank…
View article: P082 The CCR9/CCL25 axis is specific to the ileum and is correlated with stricturing disease
P082 The CCR9/CCL25 axis is specific to the ileum and is correlated with stricturing disease Open
Background Crohn’s Disease (CD) is a chronic disease in which inflammation is sustained by continuous influx of inflammatory leukocytes into gut mucosa and may affect all segments of the gastrointestinal tract. Immune cell trafficking is r…
View article: Additional file 2 of Smoking induces sex-specific changes in the small airway proteome
Additional file 2 of Smoking induces sex-specific changes in the small airway proteome Open
Additional file 2: Table S1. List of 203 proteins with RFU values > LOD in more than 50% of the samples that was used for further analysis. Table S2. Proteins significantly altered in current smokers as compared to never smokers in the joi…
View article: Leveraging Human Genetics to Estimate Clinical Risk Reductions Achievable by Inhibiting Factor XI
Leveraging Human Genetics to Estimate Clinical Risk Reductions Achievable by Inhibiting Factor XI Open
Background and Purpose— Coagulation factor XI (FXI) is a novel target for antithrombotic therapy addressed by various therapeutic modalities currently in clinical development. The expected magnitude of thrombotic event reduction mediated b…
View article: Copy number variants encompassing Mendelian disease genes in a large multigenerational family segregating bipolar disorder
Copy number variants encompassing Mendelian disease genes in a large multigenerational family segregating bipolar disorder Open
We conclude that CNVs may be contributing factors in the phenotypic presentation of mood disorders and co-morbid medical conditions in this family. These results reinforce the hypothesis of a complex genetic architecture underlying BP diso…