Benjamin H. Rotstein
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View article: PET Imaging of Cardiac SNS Function with [18F]mFBG in Heart Failure Models
PET Imaging of Cardiac SNS Function with [18F]mFBG in Heart Failure Models Open
View article: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I IFN pathway
PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I IFN pathway Open
While conventional wisdom initially postulated that PD-L1 serves as the inert ligand for PD-1, an emerging body of literature suggests that PD-L1 has cell-intrinsic functions in immune and cancer cells. In line with these studies, here we …
View article: Intramolecular Friedel‐Crafts Acylation of [<sup>11</sup>C]Isocyanates Enabling the Radiolabeling of [<i>carbonyl</i>‐<sup>11</sup>C]DPQ
Intramolecular Friedel‐Crafts Acylation of [<sup>11</sup>C]Isocyanates Enabling the Radiolabeling of [<i>carbonyl</i>‐<sup>11</sup>C]DPQ Open
α,β‐aromatic lactams are highly abundant in biologically active molecules, yet so far they cannot be radiolabeled with short‐lived (t 1/2 =20.3 min), β + ‐decaying carbon‐11, which has prevented their application as positron emission tomog…
View article: Photocatalyzed radiosynthesis of <sup>11</sup>C‐phenylacetic acids
Photocatalyzed radiosynthesis of <sup>11</sup>C‐phenylacetic acids Open
Fast and straightforward incorporation of radionuclides into pharmaceutically relevant molecules is one of the main barriers to preclinical and clinical tracer research. Late‐stage direct incorporation of cyclotron‐produced [ 11 C]CO 2 to …
View article: Quinazoline-2-Carboxamides as Selective PET Radiotracers for Matrix Metalloproteinase-13 Imaging in Atherosclerosis
Quinazoline-2-Carboxamides as Selective PET Radiotracers for Matrix Metalloproteinase-13 Imaging in Atherosclerosis Open
Matrix metalloproteinase-13 (MMP-13) plays a critical role in the progression of unstable atherosclerosis. A series of highly potent and selective MMP-13 inhibitors were synthesized around a quinazoline-2-carboxamide scaffold to facilitate…
View article: Synthesis and Evaluation of [<sup>11</sup>C]MCC950 for Imaging NLRP3-Mediated Inflammation in Atherosclerosis
Synthesis and Evaluation of [<sup>11</sup>C]MCC950 for Imaging NLRP3-Mediated Inflammation in Atherosclerosis Open
Overexpression of the NLRP3 inflammasome has been attributed to the progressive worsening of a multitude of cardiovascular inflammatory diseases such as myocardial infarction, pulmonary arterial hypertension, and atherosclerosis. The recen…
View article: More than a ligand: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I interferon pathway
More than a ligand: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I interferon pathway Open
Targeting the PD-1/PD-L1 axis has transformed the field of immune-oncology. While conventional wisdom initially postulated that PD-L1 serves as the inert ligand for PD-1, an emerging body of literature suggests that PD-L1 has cell-intrinsi…
View article: The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication
The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication Open
The tail of replication-dependent histone H3.1 varies from that of replication-independent H3.3 at the amino acid located at position 31 in plants and animals, but no function has been assigned to this residue to demonstrate a unique and c…
View article: Nanoengineered Sprayable Therapy for Treating Myocardial Infarction
Nanoengineered Sprayable Therapy for Treating Myocardial Infarction Open
We report the development, as well as the in vitro and in vivo testing, of a sprayable nanotherapeutic that uses surface engineered custom-designed multiarmed peptide grafted nanogold for on-the-spot coating of an infarcted m…
View article: Aldehyde-Catalyzed Carboxylate Exchange in a-Amino Acids with Isotopically Labeled CO2
Aldehyde-Catalyzed Carboxylate Exchange in a-Amino Acids with Isotopically Labeled CO2 Open
a-Amino acids are among the essential chemical building blocks of life. These structures are embedded in many small molecule pharmaceuticals and are the primary components of peptide-based therapeutics and biologics. Isotopically labeled a…
View article: Evaluation of Therapeutic Collagen-Based Biomaterials in the Infarcted Mouse Heart by Extracellular Matrix Targeted MALDI Imaging Mass Spectrometry
Evaluation of Therapeutic Collagen-Based Biomaterials in the Infarcted Mouse Heart by Extracellular Matrix Targeted MALDI Imaging Mass Spectrometry Open
The goal of this study was to develop strategies to localize human collagen-based hydrogels within an infarcted mouse heart, as well as analyze its impact on endogenous extracellular matrix (ECM) remodeling. Collagen is a natural polymer t…
View article: Cardiac Sympathetic Positron Emission Tomography Imaging with <i>Meta</i>-[<sup>18</sup>F]Fluorobenzylguanidine is Sensitive to Uptake-1 in Rats
Cardiac Sympathetic Positron Emission Tomography Imaging with <i>Meta</i>-[<sup>18</sup>F]Fluorobenzylguanidine is Sensitive to Uptake-1 in Rats Open
Dysfunction of the cardiac sympathetic nervous system contributes to the development of cardiovascular diseases including ischemia, heart failure, and arrhythmias. Molecular imaging probes such as meta-[123I]iodobenzylgua…
View article: Correction to: Does quantification of [11C]meta-hydroxyephedrine and [13N]ammonia kinetics improve risk stratification in ischemic cardiomyopathy
Correction to: Does quantification of [11C]meta-hydroxyephedrine and [13N]ammonia kinetics improve risk stratification in ischemic cardiomyopathy Open
View article: Does quantification of [11C]meta-hydroxyephedrine and [13N]ammonia kinetics improve risk stratification in ischemic cardiomyopathy
Does quantification of [11C]meta-hydroxyephedrine and [13N]ammonia kinetics improve risk stratification in ischemic cardiomyopathy Open
View article: A low cost and open access system for rapid synthesis of large volumes of gold and silver nanoparticles
A low cost and open access system for rapid synthesis of large volumes of gold and silver nanoparticles Open
View article: Interrupted Aza-Wittig Reactions Using Iminophosphoranes to Synthesize 11C-Carbonyls
Interrupted Aza-Wittig Reactions Using Iminophosphoranes to Synthesize 11C-Carbonyls Open
Iminophosphoranes are reported as convenient precursors to amides, ureas, carbamates and other carbonyl-containing molecules through CO2-fixation. Key to this transformation with stable isotopes and carbon-11 is interception of the reactiv…
View article: Interrupted Aza-Wittig Reactions Using Iminophosphoranes to Synthesize 11C-Carbonyls
Interrupted Aza-Wittig Reactions Using Iminophosphoranes to Synthesize 11C-Carbonyls Open
Iminophosphoranes are reported as convenient precursors to amides, ureas, carbamates and other carbonyl-containing molecules through CO2-fixation. Key to this transformation with stable isotopes and carbon-11 is interception of the reactiv…
View article: A Low Cost &amp; Open Access System for Rapid Synthesis of Large Volumes of Gold and Silver Nanoparticles
A Low Cost & Open Access System for Rapid Synthesis of Large Volumes of Gold and Silver Nanoparticles Open
Rapid synthesis of nanomaterials in scalable quantities is critical for accelerating discovery and commercial translation of nanoscale-based technologies. The synthesis of metal nanogold and silver in volumes larger than 100 mL is not auto…
View article: Fluorine-18-Labeled Fluorescent Dyes for Dual-Mode Molecular Imaging
Fluorine-18-Labeled Fluorescent Dyes for Dual-Mode Molecular Imaging Open
Recent progress realized in the development of optical imaging (OPI) probes and devices has made this technique more and more affordable for imaging studies and fluorescence-guided surgery procedures. However, this imaging modality still s…
View article: Fast Carbon Isotope Exchange of Carboxylic Acids Enabled by Organic Photoredox Catalysis
Fast Carbon Isotope Exchange of Carboxylic Acids Enabled by Organic Photoredox Catalysis Open
Carbazole/cyanobenzene photocatalysts promote the direct isotopic carboxylate exchange of C(sp3 )-acids with labelled CO2. Substrates that are not compatible with transition metal catalyzed degradation-reconstruction approaches or prone to…
View article: Fast Carbon Isotope Exchange of Carboxylic Acids Enabled by Organic Photoredox Catalysis
Fast Carbon Isotope Exchange of Carboxylic Acids Enabled by Organic Photoredox Catalysis Open
Carbazole/cyanobenzene photocatalysts promote the direct isotopic carboxylate exchange of C(sp3 )-acids with labelled CO2. Substrates that are not compatible with transition metal catalyzed degradation-reconstruction approaches or prone to…
View article: First-in-human imaging and kinetic analysis of vesicular acetylcholine transporter density in the heart using [18F]FEOBV PET
First-in-human imaging and kinetic analysis of vesicular acetylcholine transporter density in the heart using [18F]FEOBV PET Open
View article: Rhodium-Catalyzed Addition of Organozinc Iodides to Carbon-11 Isocyanates
Rhodium-Catalyzed Addition of Organozinc Iodides to Carbon-11 Isocyanates Open
Amides were prepared using rhodium-catalyzed coupling of organozinc iodides and carbon-11 (11C, t1/2 = 20.4 min) isocyanates. Nonradioactive isocyanates and sp3 or sp2 organozinc iodides g…
View article: Development of [<sup>18</sup>F]Maleimide-Based Glycogen Synthase Kinase-3β Ligands for Positron Emission Tomography Imaging
Development of [<sup>18</sup>F]Maleimide-Based Glycogen Synthase Kinase-3β Ligands for Positron Emission Tomography Imaging Open
Dysregulation of glycogen synthase kinase-3β (GSK-3β) is implicated in the pathogenesis of neurodegenerative and psychiatric disorders. Thus, development of GSK-3β radiotracers for positron emission tomography (PET) imaging is of paramount…
View article: Metal-free <sup>18</sup>F-labeling of aryl-CF<sub>2</sub>H via nucleophilic radiofluorination and oxidative C–H activation
Metal-free <sup>18</sup>F-labeling of aryl-CF<sub>2</sub>H via nucleophilic radiofluorination and oxidative C–H activation Open
A metal-free and selective method to form [18F]aryl-CF2H through nucleophilic radiofluorination of benzyl (pseudo)halides and oxidative C–H activation of benzylic C–H bonds has been developed.
View article: Mechanistic studies and radiofluorination of structurally diverse pharmaceuticals with spirocyclic iodonium(<scp>iii</scp>) ylides
Mechanistic studies and radiofluorination of structurally diverse pharmaceuticals with spirocyclic iodonium(<span>iii</span>) ylides Open
Theoretical studies provide insight into radiofluorination of non-activated electron-rich and sterically hindered 18 F-arenes using a new class of adamantyl-based spirocyclic iodonium( iii ) ylide precursors.
View article: Preclinical PET Neuroimaging of [<sup>11</sup>C]Bexarotene
Preclinical PET Neuroimaging of [<sup>11</sup>C]Bexarotene Open
Activation of retinoid X receptors (RXRs) has been proposed as a therapeutic mechanism for the treatment of neurodegeneration, including Alzheimer's and Parkinson's diseases. We previously reported radiolabeling of a Food and Drug Administ…
View article: Synthesis and Preclinical Evaluation of Sulfonamido-based [<sup>11</sup>C-<i>Carbonyl</i>]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase
Synthesis and Preclinical Evaluation of Sulfonamido-based [<sup>11</sup>C-<i>Carbonyl</i>]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase Open
Monoacylglycerol lipase (MAGL) is a 33 kDa member of the serine hydrolase superfamily that preferentially degrades 2-arachidonoylglycerol (2-AG) to arachidonic acid in the endocannabinoid system. Inhibition of MAGL is not only of interest …
View article: <sup>11</sup>CO bonds made easily for positron emission tomography radiopharmaceuticals
<sup>11</sup>CO bonds made easily for positron emission tomography radiopharmaceuticals Open
This review explores11C-carbonylation as an alternative set of strategies to11C-methylation for the design and development of radiotracers for positron emission tomography.
View article: Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([<sup>11</sup>C]MPPO) Based on α-Ketoheterocyclic Scaffold
Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([<sup>11</sup>C]MPPO) Based on α-Ketoheterocyclic Scaffold Open
Fatty acid amide hydrolase (FAAH) is one of the principle enzymes for metabolizing endogenous cannabinoid neurotransmitters such as anandamide, and thus regulates endocannabinoid (eCB) signaling. Selective pharmacological blockade of FAAH …