Benjamin H. Schott
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View article: Biological sex affects gene expression and functional variation across the human genome
Biological sex affects gene expression and functional variation across the human genome Open
Summary Humans display sexual dimorphism across many traits, but little is known about underlying genetic mechanisms and impacts on disease. We utilized single-cell RNA-seq of 480 lymphoblastoid cell lines to identify 1200 genes with signi…
View article: Single-cell genome-wide association reveals that a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus
Single-cell genome-wide association reveals that a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus Open
During pandemics, individuals exhibit differences in risk and clinical outcomes. Here, we developed single-cell high-throughput human in vitro susceptibility testing (scHi-HOST), a method for rapidly identifying genetic variants that confe…
View article: The Awesome Power of Human Genetics of Infectious Disease
The Awesome Power of Human Genetics of Infectious Disease Open
Since the identification of sickle cell trait as a heritable form of resistance to malaria, candidate gene studies, linkage analysis paired with sequencing, and genome-wide association (GWA) studies have revealed many examples of genetic r…
View article: Integration of the <i>Salmonella</i> Typhimurium Methylome and Transcriptome Reveals That DNA Methylation and Transcriptional Regulation Are Largely Decoupled under Virulence-Related Conditions
Integration of the <i>Salmonella</i> Typhimurium Methylome and Transcriptome Reveals That DNA Methylation and Transcriptional Regulation Are Largely Decoupled under Virulence-Related Conditions Open
While recent breakthroughs have enabled intense study of bacterial DNA modifications, limitations in current work have potentiated a surprisingly untested narrative that DNA methylation is a common mechanism of the bacterial response to en…
View article: Single-cell genome-wide association reveals a nonsynonymous variant in<i>ERAP1</i>confers increased susceptibility to influenza virus
Single-cell genome-wide association reveals a nonsynonymous variant in<i>ERAP1</i>confers increased susceptibility to influenza virus Open
Summary Diversity in the human genome is one factor that confers resistance and susceptibility to infectious diseases. This is observed most dramatically during pandemics, where individuals exhibit large differences in risk and clinical ou…
View article: Integration of the <i>Salmonella</i> Typhimurium methylome and transcriptome reveals DNA methylation and transcriptional regulation are largely decoupled under virulence-related conditions
Integration of the <i>Salmonella</i> Typhimurium methylome and transcriptome reveals DNA methylation and transcriptional regulation are largely decoupled under virulence-related conditions Open
Despite being in a golden age of bacterial epigenomics, little work has systematically examined the plasticity and functional impacts of the bacterial DNA methylome. Here, we leveraged SMRT sequencing to examine the m 6 A DNA methylome of …
View article: Pathogen Evasion of Chemokine Response Through Suppression of CXCL10
Pathogen Evasion of Chemokine Response Through Suppression of CXCL10 Open
Leishmaniasis, an infectious disease that annually affects over one million people, is caused by intracellular parasites that have evolved to evade the host's attempts to eliminate the parasite. Cutaneous leishmaniasis results in disfiguri…