Benjamin Hanf
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View article: Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma
Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma Open
Although generally curable with intensive chemotherapy in resource-rich settings, Burkitt lymphoma (BL) remains a deadly disease in older patients and in sub-Saharan Africa. Epstein-Barr virus (EBV) positivity is a feature in more than 90%…
View article: Adaptation strategies of Aspergillus species to environmental challenges
Adaptation strategies of Aspergillus species to environmental challenges Open
Evolution shaped the adaptability of Aspergilli to diverse stress conditions, such as low temperature or adaptation to hostile environments. We applied different assays and multi-omics approaches to gain deeper understanding about these st…
View article: ATP Content and Cell Viability as Indicators for Cryostress Across the Diversity of Life
ATP Content and Cell Viability as Indicators for Cryostress Across the Diversity of Life Open
In many natural environments, organisms get exposed to low temperature and/or to strong temperature shifts. Also, standard preservation protocols for live cells or tissues involve ultradeep freezing in or above liquid nitrogen (-196°C or -…
View article: Phenotypic and Proteomic Analysis of the Aspergillus fumigatus ΔPrtT, ΔXprG and ΔXprG/ΔPrtT Protease-Deficient Mutants
Phenotypic and Proteomic Analysis of the Aspergillus fumigatus ΔPrtT, ΔXprG and ΔXprG/ΔPrtT Protease-Deficient Mutants Open
Aspergillus fumigatus is the most common mold species to cause disease in immunocompromised patients. Infection usually begins when its spores (conidia) are inhaled into the airways, where they germinate, forming hyphae that penetrate and …
View article: Novel Insights in the Regulation of Phosphatidylserine Exposure in Human Red Blood Cells
Novel Insights in the Regulation of Phosphatidylserine Exposure in Human Red Blood Cells Open
Background/Aims: In previous publications we were able to demonstrate the exposure of phosphatidylserine (PS) in the outer membrane leaflet after activation of red blood cells (RBCs) by lysophosphatidic acid (LPA), phorbol-12 myristate-13a…
View article: Phosphatidylserine Exposure in Human Red Blood Cells Depending on Cell Age
Phosphatidylserine Exposure in Human Red Blood Cells Depending on Cell Age Open
Background/Aims: The exposure of phosphatidylserine (PS) on the outer membrane leaflet of red blood cells (RBCs) serves as a signal for suicidal erythrocyte death or eryptosis, which may be of importance for cell clearance from blood circu…
View article: Prevention of the degeneration of human dopaminergic neurons in an astrocyte co‐culture system allowing endogenous drug metabolism
Prevention of the degeneration of human dopaminergic neurons in an astrocyte co‐culture system allowing endogenous drug metabolism Open
Background and Purpose Few neuropharmacological model systems use human neurons. Moreover, available test systems rarely reflect functional roles of co‐cultured glial cells. There is no human in vitro counterpart of the widely used 1‐methy…