Benjamin D. Heuberger
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View article: Replacing Uridine with 2-Thiouridine Enhances the Rate and Fidelity of Nonenzymatic RNA Primer Extension
Replacing Uridine with 2-Thiouridine Enhances the Rate and Fidelity of Nonenzymatic RNA Primer Extension Open
The nonenzymatic replication of RNA oligonucleotides is thought to have played a key role in the origin of life prior to the evolution of ribozyme-catalyzed RNA replication. Although the copying of oligo-C templates by 2-methylimidazole-ac…
View article: Crystal Structure Studies of RNA Duplexes Containing s<sup>2</sup>U:A and s<sup>2</sup>U:U Base Pairs
Crystal Structure Studies of RNA Duplexes Containing s<sup>2</sup>U:A and s<sup>2</sup>U:U Base Pairs Open
Structural studies of modified nucleobases in RNA duplexes are critical for developing a full understanding of the stability and specificity of RNA base pairing. 2-Thio-uridine (s(2)U) is a modified nucleobase found in certain tRNAs. Therm…
View article: Lack of bioavailability of dichlorobenzidine from diarylide azo pigments: molecular dosimetry for hemoglobin and DNA adducts
Lack of bioavailability of dichlorobenzidine from diarylide azo pigments: molecular dosimetry for hemoglobin and DNA adducts Open
The hypothetical release of 3,3'-dichlorobenzidine (DCB) from two insoluble azo pigments and from a soluble azo dye was investigated in female Wistar rats for a 4 week treatment with 0.2% (w/w) Colour Index Pigment 13 (PY13) or 0.2% (w/w) …