Benjamin Hofner
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View article: Clinical trials with interim analyses: Standardizing Terminology to increase clarity
Clinical trials with interim analyses: Standardizing Terminology to increase clarity Open
Interim analyses for group-sequential decision making are prevalent in clinical trials. Methodology is well established and has been routinely implemented over the last decades. Still, confusions and uncertainties on aspects of how to oper…
View article: Regulatory Issues of Platform Trials: Learnings from EU‐PEARL
Regulatory Issues of Platform Trials: Learnings from EU‐PEARL Open
Although platform trials have many benefits, the complexity of these designs may result not only in increased methodological but also regulatory and ethical challenges. These aspects were addressed as part of the IMI project EU Patient‐Cen…
View article: Adaptive platform trials: the impact of common controls on type one error and power
Adaptive platform trials: the impact of common controls on type one error and power Open
Platform trials offer a framework to study multiple interventions in one trial with the opportunity of opening and closing arms. The use of common controls can increase efficiency as compared to individual controls. The need for multiplici…
View article: Vaccine Development during a Pandemic: General Lessons for Clinical Trial Design
Vaccine Development during a Pandemic: General Lessons for Clinical Trial Design Open
The COVID-19 pandemic triggered an unprecedented research effort to develop vaccines and therapeutics. Urgency dictated that development and regulatory assessment were accelerated, while maintaining all standards for quality, safety and ef…
View article: A unified framework towards diagnostic test development and evaluation during outbreaks of emerging infections
A unified framework towards diagnostic test development and evaluation during outbreaks of emerging infections Open
Background Diagnostic tests play a crucial role during an epidemic or a pandemic, both for individual patient care, and as a tool in population-level non-pharmaceutical interventions. The development and evaluation of such tests during epi…
View article: Platform Trials: the Impact of common Controls on Type One Error and Power
Platform Trials: the Impact of common Controls on Type One Error and Power Open
Platform trials offer a framework to study multiple interventions in a single trial with the opportunity of opening and closing arms. The use of a common control in platform trials can increase efficiency as compared to individual control …
View article: Adaptive platform trials: the impact of common controls on type one error and power
Adaptive platform trials: the impact of common controls on type one error and power Open
Platform trials offer a framework to study multiple interventions in one trial with the opportunity of opening and closing arms. The use of common controls can increase efficiency as compared to individual controls. The need for multiplici…
View article: Modelling Flow in Gas Transmission Networks Using Shape-Constrained Expectile Regression
Modelling Flow in Gas Transmission Networks Using Shape-Constrained Expectile Regression Open
The flow of natural gas within a gas transmission network is studied with the aim to model high-demand situations. Knowledge about the latter can be used to optimise such networks. The analysis of data using shape-constrained expectile reg…
View article: Stochastic Dispersal Rather Than Deterministic Selection Explains the Spatio-Temporal Distribution of Soil Bacteria in a Temperate Grassland
Stochastic Dispersal Rather Than Deterministic Selection Explains the Spatio-Temporal Distribution of Soil Bacteria in a Temperate Grassland Open
Spatial and temporal processes shaping microbial communities are inseparably linked but rarely studied together. By Illumina 16S rRNA sequencing, we monitored soil bacteria in 360 stations on a 100 square meter plot distributed across six …
View article: EMA Review of Axicabtagene Ciloleucel (Yescarta) for the Treatment of Diffuse Large B-Cell Lymphoma
EMA Review of Axicabtagene Ciloleucel (Yescarta) for the Treatment of Diffuse Large B-Cell Lymphoma Open
On June 28, 2018, the Committee for Advanced Therapies and the Committee for Medicinal Products for Human Use adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Yescarta for the tre…
View article: Publisher Correction: Optimizing the dynamics of protein expression
Publisher Correction: Optimizing the dynamics of protein expression Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Optimizing the dynamics of protein expression
Optimizing the dynamics of protein expression Open
Heterologously expressed genes require adaptation to the host organism to ensure adequate levels of protein synthesis, which is typically approached by replacing codons by the target organism’s preferred codons. In view of frequently encou…
View article: Modeling spatiotemporal abundance of mobile wildlife in highly variable environments using boosted GAMLSS hurdle models
Modeling spatiotemporal abundance of mobile wildlife in highly variable environments using boosted GAMLSS hurdle models Open
Modeling organism distributions from survey data involves numerous statistical challenges, including accounting for zero‐inflation, overdispersion, and selection and incorporation of environmental covariates. In environments with high spat…
View article: The<i>betaboost</i>package—a software tool for modelling bounded outcome variables in potentially high-dimensional epidemiological data
The<i>betaboost</i>package—a software tool for modelling bounded outcome variables in potentially high-dimensional epidemiological data Open
The software is hosted publicly at [http://github.com/boost-R/betaboost] and has been published under General Public License (GPL) version 3 or newer.
View article: Bouldering psychotherapy reduces depressive symptoms even when general physical activity is controlled for: A randomized controlled trial
Bouldering psychotherapy reduces depressive symptoms even when general physical activity is controlled for: A randomized controlled trial Open
This study provides evidence that short-term BPT can be effective for reducing symptoms of depression even if controlled for other therapeutically active confounders including antidepressant medication, psychotherapy and general level of P…
View article: Boosting for statistical modelling-A non-technical introduction
Boosting for statistical modelling-A non-technical introduction Open
Boosting algorithms were originally developed for machine learning but were later adapted to estimate statistical models—offering various practical advantages such as automated variable selection and implicit regularization of effect estim…
View article: Spatiotemporal modelling of sea duck abundance: implications for marine spatial planning
Spatiotemporal modelling of sea duck abundance: implications for marine spatial planning Open
Effective marine spatial plans require information on the distribution and abundance of biological resources that are potentially vulnerable to anthropogenic change. In North America, spatially-explicit abundance estimates of marine birds …
View article: An update on statistical boosting in biomedicine
An update on statistical boosting in biomedicine Open
Statistical boosting algorithms have triggered a lot of research during the last decade. They combine a powerful machine-learning approach with classical statistical modelling, offering various practical advantages like automated variable …
View article: An Update on Statistical Boosting in Biomedicine
An Update on Statistical Boosting in Biomedicine Open
Statistical boosting algorithms have triggered a lot of research during the last decade. They combine a powerful machine learning approach with classical statistical modelling, offering various practical advantages like automated variable …
View article: Pathway-Based Kernel Boosting for the Analysis of Genome-Wide Association Studies
Pathway-Based Kernel Boosting for the Analysis of Genome-Wide Association Studies Open
The analysis of genome-wide association studies (GWAS) benefits from the investigation of biologically meaningful gene sets, such as gene-interaction networks (pathways). We propose an extension to a successful kernel-based pathway analysi…
View article: <b>gamboostLSS</b>: An <i>R</i> Package for Model Building and Variable Selection in the GAMLSS Framework
<b>gamboostLSS</b>: An <i>R</i> Package for Model Building and Variable Selection in the GAMLSS Framework Open
Generalized additive models for location, scale and shape are a flexible class of regression models that allow to model multiple parameters of a distribution function, such as the mean and the standard deviation, simultaneously. With the R…
View article: Supplement 1. R code for conducting statistical analysis of Red Kite distribution and for the simulation study.
Supplement 1. R code for conducting statistical analysis of Red Kite distribution and for the simulation study. Open
File List simulation.R figures.R redkite/model_monotonic.R redkite/plot_fun.R redkite/bva.Rda redkite/variables.csv redkite/XY.RdaDescription "simulation.R" : This file contains R codes to perform the following: Set up and perform simulati…