B. Zane Horowitz
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View article: PTHP-17. Beyond DNA: Two Pediatric Glioma Cases Highlight the Diagnostic and Therapeutic Impact of RNA Sequencing
PTHP-17. Beyond DNA: Two Pediatric Glioma Cases Highlight the Diagnostic and Therapeutic Impact of RNA Sequencing Open
Pediatric gliomas have diverse molecular profiles that can evade detection through conventional DNA-based testing. While DNA profiling is a frontline tool, it may miss oncogenic fusions or expression patterns critical for targeted therapy.…
View article: NANCY: Next-generation All-sky Near-infrared Community surveY
NANCY: Next-generation All-sky Near-infrared Community surveY Open
The Nancy Grace Roman Space Telescope is capable of delivering an unprecedented all-sky, high-spatial resolution, multi-epoch infrared map to the astronomical community. This opportunity arises in the midst of numerous ground- and space-ba…
View article: Early-onset, conjugal, twin-discordant, and clusters of sporadic ALS: Pathway to discovery of etiology via lifetime exposome research
Early-onset, conjugal, twin-discordant, and clusters of sporadic ALS: Pathway to discovery of etiology via lifetime exposome research Open
The identity and role of environmental factors in the etiology of sporadic amyotrophic lateral sclerosis (sALS) is poorly understood outside of three former high-incidence foci of Western Pacific ALS and a hotspot of sALS in the French Alp…
View article: Differentiable Stochastic Halo Occupation Distribution
Differentiable Stochastic Halo Occupation Distribution Open
In this work, we demonstrate how differentiable stochastic sampling techniques developed in the context of deep Reinforcement Learning can be used to perform efficient parameter inference over stochastic, simulation-based, forward models. …
View article: Changes in Suicidal Ingestion Among Preadolescent Children From 2000 to 2020
Changes in Suicidal Ingestion Among Preadolescent Children From 2000 to 2020 Open
This cross-sectional study examines the rates of intentional misuse of substances in US children aged 6 to 18 years in the past 20 years.
View article: Continuous extracorporeal clearance in metformin-associated lactic acidosis and metformin-induced lactic acidosis: a systematic review
Continuous extracorporeal clearance in metformin-associated lactic acidosis and metformin-induced lactic acidosis: a systematic review Open
Metformin poisoning with lactic acidosis is an uncommon yet clinically serious condition related to the inhibition of normal aerobic metabolism. Toxicity may occur after an acute overdose although it is much more common after a systemic in…
View article: Botulism
Botulism Open
Audience: This simulation is targeted to emergency medicine residents and medical students.This case focuses on the diagnosis and management of botulism toxicity, while highlighting the logistical complications of botulism toxicity. Introd…
View article: Botulism
Botulism Open
Emergency medicine residents expressed positive feedback on the scenario. The residents appreciated the change in clinical course of the patient over time as well as the presentation of botulism.Discussion: This simulation is an effective …
View article: Tear gas in America: Cry the Beloved Country
Tear gas in America: Cry the Beloved Country Open
Tear gas agents are divided into “C” agents, and “pepper spray” and are currently being used by law enforcement. CN (1-chloroacetophenone) is more toxic, sometimes causing skin blistering in addition to eye lacrimation. It was replaced by …
View article: Looking backward, looking forward
Looking backward, looking forward Open
January derives its name from the Roman god Janus, whose two faces look backward into the past and forward into the future.As we look back at the first two years of Toxicology Communications, we se...
View article: Prevalence of CKD, Diabetes, and Hypertension in Rural Tanzania
Prevalence of CKD, Diabetes, and Hypertension in Rural Tanzania Open
Although this pilot study had a relatively small sample size, the prevalence estimates for CKD, diabetes, and hypertension were higher than we expected based on previous estimates from Tanzania. CKD was not significantly associated with di…
View article: Awareness, self-management behaviors, health literacy and kidney function relationships in specialty practice
Awareness, self-management behaviors, health literacy and kidney function relationships in specialty practice Open
CKD-A is not associated with HL, or better CKD-SMBs. CKD-A is significantly associated with kidney function and substantially lower eGFR, suggesting the need for focused patient education in CKD stages 1.
View article: Falsely elevated serum salicylate concentration secondary to hyperlipidemia
Falsely elevated serum salicylate concentration secondary to hyperlipidemia Open
Dear Editor,We report a case of falsely elevated salicylate concentration similar to the case reported by Biary et al. [1] published earlier this year.A 46-year-old male presented to the emergency ...
View article: Suicidal bupropion ingestions in adolescents: increased morbidity compared with other antidepressants
Suicidal bupropion ingestions in adolescents: increased morbidity compared with other antidepressants Open
Adolescents who overdose on a single medication in a suicide attempt with bupropion have a statistically significant higher incidence of major outcomes and seizures. The risks of bupropion as a potential means of suicidal gesture by overdo…