Benjamin J. Marsland
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View article: 61 A core Human Skin Cell Atlas enables transfer learning–based mapping of inflammatory skin diseases
61 A core Human Skin Cell Atlas enables transfer learning–based mapping of inflammatory skin diseases Open
View article: Bacterial communities co-develop with respiratory immunity early in life, linking dysbiosis to systemic monocyte signature and wheezing
Bacterial communities co-develop with respiratory immunity early in life, linking dysbiosis to systemic monocyte signature and wheezing Open
Early microbial colonization influences respiratory disease risk, yet mechanisms remain unclear. In a prospective birth cohort of 256 infants, we profiled bacterial, fungal, and viral communities in the upper airway and assessed local immu…
View article: Immune cell profiling reveals diverse niches of immune residents of the enteric nervous system and potential neuroimmune interactions
Immune cell profiling reveals diverse niches of immune residents of the enteric nervous system and potential neuroimmune interactions Open
Gastrointestinal (GI) neuroimmune interactions are crucial sensors and regulators of tissue homeostasis. Most enteric neurons reside within the myenteric plexus of the enteric nervous system in the muscular region, forming a structure call…
View article: Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis Open
Prolonged exposure to a high-fat diet (HFD) exacerbates intestinal disease pathology, yet the early events preceding the development of gut inflammation remain poorly understood. Here, we show that within 48 h, HFD impairs intestinal group…
View article: Early‐Life Host–Microbial Interactions and Asthma Development: A Lifelong Impact?
Early‐Life Host–Microbial Interactions and Asthma Development: A Lifelong Impact? Open
Childhood is a multifactorial disease, and recent research highlights the influence of early‐life microbial communities in shaping disease risk. This review explores the roles of the gut and respiratory microbiota in asthma development, em…
View article: A high fat, high sugar diet exacerbates persistent post-surgical pain and modifies the brain-microbiota-gut axis in adolescent rats
A high fat, high sugar diet exacerbates persistent post-surgical pain and modifies the brain-microbiota-gut axis in adolescent rats Open
Persistent post-surgical pain (PPSP) occurs in a proportion of patients following surgical interventions. Research suggests that specific microbiome components are important for brain development and function, with recent studies demonstra…
View article: Time restricted feeding alters the behavioural and physiological outcomes to repeated mild traumatic brain injury in male and female rats
Time restricted feeding alters the behavioural and physiological outcomes to repeated mild traumatic brain injury in male and female rats Open
Mild traumatic brain injury (mTBI) research has had limited success translating treatments from preclinical models to clinical application for concussion. One major factor that has been overlooked is the near 24-hour availability of food, …
View article: Deep multiomic profiling reveals molecular signatures that underpin preschool wheeze and asthma
Deep multiomic profiling reveals molecular signatures that underpin preschool wheeze and asthma Open
These factors highlighted distinctions between an inflammation-related phenotype in preschool wheeze, and the predominance of airway epithelial-related changes linked with the inferred trajectory toward asthma. These findings provide insig…
View article: Helminth infection driven gastrointestinal hypermotility is independent of eosinophils and mediated by alterations in smooth muscle instead of enteric neurons
Helminth infection driven gastrointestinal hypermotility is independent of eosinophils and mediated by alterations in smooth muscle instead of enteric neurons Open
Intestinal helminth infection triggers a type 2 immune response that promotes a ‘weep-and sweep’ response characterised by increased mucus secretion and intestinal hypermotility, which function to dislodge the worm from its intestinal habi…
View article: Breaking down silos: The Gastroenterology Immunology Neuroscience (GIN) Discovery Program – a new model for research
Breaking down silos: The Gastroenterology Immunology Neuroscience (GIN) Discovery Program – a new model for research Open
The Gastroenterology Immunology Neuroscience (GIN) Discovery Program represents a new model for research that overcomes the limitations imposed by traditional “research silos” in science. By uniting these three fields, the GIN Program aims…
View article: Holding glycolysis in check though Alox15 activity is required for macrophage M2 commitment and function in tissue repair and anti-helminth immunity
Holding glycolysis in check though Alox15 activity is required for macrophage M2 commitment and function in tissue repair and anti-helminth immunity Open
Macrophage polarization by type-2 cytokines is central to anti-helminth immunity and tissue repair. While some hallmark changes in macrophages are well-characterized and associated with protection against helminths, it is still unclear how…
View article: Multi‐omics integration reveals a nonlinear signature that precedes progression of lung fibrosis
Multi‐omics integration reveals a nonlinear signature that precedes progression of lung fibrosis Open
Objectives Idiopathic pulmonary fibrosis (IPF) is a devastating progressive interstitial lung disease with poor outcomes. While decades of research have shed light on pathophysiological mechanisms associated with the disease, our understan…
View article: Neuroimmunology of the Lung
Neuroimmunology of the Lung Open
Barrier tissues are highly innervated by sensory and autonomic nerves that are positioned in close proximity to both stromal and immune cell populations. Together with a growing awareness of the far-reaching consequences of neuroimmune int…
View article: Helminth infection driven gastrointestinal hypermotility is independent of eosinophils and mediated by alterations in smooth muscle instead of enteric neurons
Helminth infection driven gastrointestinal hypermotility is independent of eosinophils and mediated by alterations in smooth muscle instead of enteric neurons Open
Intestinal helminth infection triggers a type 2 immune response that promotes a ‘weep-and sweep’ response characterised by increased mucus secretion and intestinal hypermotility, which function to dislodge the worm from its intestinal habi…
View article: Gut instinct: Sex differences in the gut microbiome are associated with changes in adolescent nociception following maternal separation in rats
Gut instinct: Sex differences in the gut microbiome are associated with changes in adolescent nociception following maternal separation in rats Open
Adolescent chronic pain is a growing public health epidemic. Our understanding of its etiology is limited; however, several factors can increase susceptibility, often developing in response to an acute pain trigger such as a surgical proce…
View article: Butyrate regulates neutrophil homeostasis and impairs early antimicrobial activity in the lung
Butyrate regulates neutrophil homeostasis and impairs early antimicrobial activity in the lung Open
Short-chain fatty acids (SCFAs) are metabolites that are produced after microbial fermentation of dietary fiber and impact cell metabolism and anti-inflammatory pathways both locally in the gut and systemically. In preclinical models, admi…
View article: Systems prediction of chronic lung allograft dysfunction: Results and perspectives from the Cohort of Lung Transplantation and Systems prediction of Chronic Lung Allograft Dysfunction cohorts
Systems prediction of chronic lung allograft dysfunction: Results and perspectives from the Cohort of Lung Transplantation and Systems prediction of Chronic Lung Allograft Dysfunction cohorts Open
Background Chronic lung allograft dysfunction (CLAD) is the leading cause of poor long-term survival after lung transplantation (LT). Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) aimed to predict CLAD. Methods To pred…
View article: The skin microbiome in the first year of life and its association with atopic dermatitis
The skin microbiome in the first year of life and its association with atopic dermatitis Open
Background Early‐life microbial colonization of the skin may modulate the immune system and impact the development of atopic dermatitis (AD) and allergic diseases later in life. To address this question, we assessed the association between…
View article: Age matters: Microbiome depletion prior to repeat mild traumatic brain injury differentially alters microbial composition and function in adolescent and adult rats
Age matters: Microbiome depletion prior to repeat mild traumatic brain injury differentially alters microbial composition and function in adolescent and adult rats Open
Dysregulation of the gut microbiome has been shown to perpetuate neuroinflammation, alter intestinal permeability, and modify repetitive mild traumatic brain injury (RmTBI)-induced deficits. However, there have been no investigations regar…
View article: Strain-specific impacts of probiotics are a significant driver of gut microbiome development in very preterm infants
Strain-specific impacts of probiotics are a significant driver of gut microbiome development in very preterm infants Open
The development of the gut microbiome from birth plays important roles in short- and long-term health, but factors influencing preterm gut microbiome development are poorly understood. In the present study, we use metagenomic sequencing to…
View article: Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation
Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation Open
Barrier integrity is central to the maintenance of healthy immunological homeostasis. Impaired skin barrier function is linked with enhanced allergen sensitization and the development of diseases such as atopic dermatitis (AD), which can p…
View article: Early life inter-kingdom interactions shape the immunological environment of the airways
Early life inter-kingdom interactions shape the immunological environment of the airways Open
Background There is increasing evidence that the airway microbiome plays a key role in the establishment of respiratory health by interacting with the developing immune system early in life. While it has become clear that bacteria are invo…
View article: Of bats and men: Immunomodulatory treatment options for COVID-19 guided by the immunopathology of SARS-CoV-2 infection
Of bats and men: Immunomodulatory treatment options for COVID-19 guided by the immunopathology of SARS-CoV-2 infection Open
SARS-CoV-2 evades immune recognition in humans but not bats, pointing to potential strategies for therapeutic intervention.
View article: Protection against allergies: Microbes, immunity, and the farming effect
Protection against allergies: Microbes, immunity, and the farming effect Open
The prevalence of asthma and other allergic diseases has rapidly increased in “Westernized” countries over recent decades. This rapid increase suggests the involvement of environmental factors, behavioral changes or lifestyle, rather than …
View article: FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure
FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure Open
Foxc2 sustains adult lymphatic vascular specialization and coordinates organ-specific lymph flow, gut microbiota, and inflammation.
View article: Multi-omics profiling predicts allograft function after lung transplantation
Multi-omics profiling predicts allograft function after lung transplantation Open
Rationale Lung transplantation is the ultimate treatment option for patients with end-stage respiratory diseases but bears the highest mortality rate among all solid organ transplantations due to chronic lung allograft dysfunction (CLAD). …
View article: A prevalent and culturable microbiota links ecological balance to clinical stability of the human lung after transplantation
A prevalent and culturable microbiota links ecological balance to clinical stability of the human lung after transplantation Open
There is accumulating evidence that the lower airway microbiota impacts lung health. However, the link between microbial community composition and lung homeostasis remains elusive. We combine amplicon sequencing and bacterial culturing to …
View article: Fecal Microbiota Nutrient Utilization Potential Suggests Mucins as Drivers for Initial Gut Colonization of Mother-Child-Shared Bacteria
Fecal Microbiota Nutrient Utilization Potential Suggests Mucins as Drivers for Initial Gut Colonization of Mother-Child-Shared Bacteria Open
The initial bacterial colonization of human infants is crucial for lifelong health. Understanding the factors driving this colonization will therefore be of great importance.
View article: Developments allergy in 2019 through the eyes of clinical and experimental allergy, part I mechanisms
Developments allergy in 2019 through the eyes of clinical and experimental allergy, part I mechanisms Open
In the first of two linked articles, we describe the development in the mechanisms underlying allergy as described by Clinical & Experimental Allergy and other journals in 2019. Experimental models of allergic disease, basic mechanisms, cl…
View article: De novo species identification using 16S rRNA gene nanopore sequencing
De novo species identification using 16S rRNA gene nanopore sequencing Open
Nanopore sequencing is rapidly becoming more popular for use in various microbiota-based applications. Major limitations of current approaches are that they do not enable de novo species identification and that they cannot be used to verif…