Bruce A. Smith
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View article: The role of carnitine palmitoyl transferase 2 in the progression of salt-sensitive hypertension
The role of carnitine palmitoyl transferase 2 in the progression of salt-sensitive hypertension Open
Although high-salt diets have been shown to negatively impact cardiovascular health, the ketogenic diet has demonstrated beneficial effects. In the current study, we created a model of CPT2 deficiency on a salt-sensitive background and sho…
View article: Changes in first-line treatment patterns according to frailty in chronic lymphocytic leukemia/small lymphocytic lymphoma
Changes in first-line treatment patterns according to frailty in chronic lymphocytic leukemia/small lymphocytic lymphoma Open
Novel therapies have transformed treatment for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), but how they have changed treatment for frail patients is unclear. Using Surveillance, Epidemiology, and End Results-Medicare…
View article: Hospital-Based Stigma Practices Towards Individuals With Opioid Use Disorder: A Qualitative Study in Austin, Texas
Hospital-Based Stigma Practices Towards Individuals With Opioid Use Disorder: A Qualitative Study in Austin, Texas Open
Stigma experienced in hospital settings has significant consequences for patients with OUD. Hospital systems must implement policies that promote patient-centered practices and avoid stigmatizing practices to improve hospital-based care de…
View article: Real-time tracking of lung tumors using a 1.5T Elekta Unity MR-Linac: first clinical experiences
Real-time tracking of lung tumors using a 1.5T Elekta Unity MR-Linac: first clinical experiences Open
There is a growing interest in the application of MRI-guided adaptive radiotherapy (MRIgART) to improve the treatment of lung tumors. Motion management plays a central role to better localize these tumors and minimize toxicities to surroun…
View article: Prey size mediates interference competition and predation dynamics in a large carnivore community
Prey size mediates interference competition and predation dynamics in a large carnivore community Open
Direct competition for resources is especially fierce among predators, leading to disproportionately strong effects on fitness and functional roles. These competitive effects are exacerbated in complex predator guilds with dominance hierar…
View article: Metastatic seminoma presenting in an external iliac lymph node in an asymptomatic elderly patient undergoing screening in a multi-cancer early detection study: Report of a case and review of the literature
Metastatic seminoma presenting in an external iliac lymph node in an asymptomatic elderly patient undergoing screening in a multi-cancer early detection study: Report of a case and review of the literature Open
Multi-cancer early detection assays are being increasingly studied as a way to efficiently and effectively screen for low-stage and treatable cancers from various tissue origins with a single blood test. However, many of these tests suffer…
View article: Microwave Ablation of T1a and T1b Renal Masses: A Retrospective Study
Microwave Ablation of T1a and T1b Renal Masses: A Retrospective Study Open
Purpose The aim of this study was to evaluate the efficacy and safety of microwave ablation (MWA) for the treatment of T1a and T1b renal masses, with size ranges between 1.2 and 6.5 cm. Methods A retrospective review was performed at a sin…
View article: Radon Exposure and Gestational Diabetes
Radon Exposure and Gestational Diabetes Open
Importance Understanding environmental risk factors for gestational diabetes (GD) is crucial for developing preventive strategies and improving pregnancy outcomes. Objective To examine the association of county-level radon exposure with GD…
View article: Genome-wide Machine Learning Analysis of Anosmia and Ageusia with COVID-19
Genome-wide Machine Learning Analysis of Anosmia and Ageusia with COVID-19 Open
The COVID-19 pandemic has caused substantial worldwide disruptions in health, economy, and society, manifesting symptoms such as loss of smell (anosmia) and loss of taste (ageusia), that can result in prolonged sensory impairment. Establis…
View article: The Efficacy of Metformin as a Therapeutic Agent in the Treatment of Acne Vulgaris: A Systematic Review
The Efficacy of Metformin as a Therapeutic Agent in the Treatment of Acne Vulgaris: A Systematic Review Open
A large portion of the world's population is affected by acne vulgaris (AV), with many of these individuals being adolescents. The underlying mechanism of AV is hyperkeratinization and Cutibacterium acnes infection of the pilosebaceous fol…
View article: T-cell help in the tumor microenvironment enhances rituximab-mediated NK-cell ADCC
T-cell help in the tumor microenvironment enhances rituximab-mediated NK-cell ADCC Open
Rituximab (RTX) and other monoclonal antibodies (mAbs) that bind directly to malignant cells are of great clinical value but are not effective for all patients. A major mechanism of action of RTX is antibody-dependent cellular cytotoxicity…
View article: Figure S2 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Figure S2 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
Predictive power of T2* in patients receiving standard-of-care therapy.
View article: Table S1 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Table S1 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
Study Representativeness Table
View article: Table S1 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Table S1 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
Study Representativeness Table
View article: Figure S5 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Figure S5 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
U251 cells have lower basal levels of labile iron.
View article: Figure S1 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Figure S1 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
T2* relaxation in GBM and normal tissue.
View article: Figure S3 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Figure S3 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
Test, re-test study to determine inter- and intra-session variability of T2* mapping in vivo.
View article: Data from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Data from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
Purpose:Pharmacologic ascorbate (P-AscH−) is hypothesized to be an iron (Fe)-dependent tumor-specific adjuvant to chemoradiation in treating glioblastoma (GBM). This study determined the efficacy of combining P-AscH− with radiation and tem…
View article: Figure S7 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Figure S7 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
P-AscH- stimulates the release of iron as Fe2+ from ferritin.
View article: Figure S4 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Figure S4 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
Doxycycline induces ferritin heavy chain overexpression.
View article: Figure S6 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Figure S6 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
Ferritin overexpression-induced Fe metabolic perturbations.
View article: Figure S5 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Figure S5 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
U251 cells have lower basal levels of labile iron.